Confocal observation of senile plaques in Alzheimer's disease: Senile plaque morphology and relationship between senile plaques and astrocytes
Abstract
Senile plaques in the brains of Alzheimer's disease (AD) were examined by confocal laser scanning microscopy (CLSM) with the following three findings. First, in sections stained with Congo red, the serial CLSM images of optical sections clearly revealed that a classic plaque is composed of a plaque core and a corona. Radially arranged process-like structures, corresponding to bundles of amyloid fibrils, formed amyloid cores and stronger signals were detected in the center of some cores. Second, in sections stained with Congo red and anti-glial fibrillary acidic protein (GFAP), reactive astrocytes were found around the senile plaques and many astrocytic processes surrounded the plaque cores and some processes had penetrated into them. Third, three-dimensional reconstruction on classic plaque revealed that the surface of classic plaque showed a 'coral-like' appearance.
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In brain specimens from patients with AD, activated astrocytes are intimately associated with amyloid plaques.
“In brain specimens from patients with AD, activated astrocytes are intimately associated with amyloid plaques (54–56)”
From Attenuating astrocyte activation accelerates plaque pathogenesis in APP/PS1 mice (2013) · cites this paper as [54]
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Attenuating astrocyte activation accelerates plaque pathogenesis in APP/PS1 mice
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- Authors
- Kato, S., Gondo, T., Hoshii, Y., Takahashi, M., Yamada, M., & Ishihara, T.
- Affiliations
- Yamaguchi University (JP)
- Yamaguchi University Hospital (JP)
- Corresponding author
- Kato, Senri
- ORCID
- Hoshii, Yoshinobu
- Venue
- Pathology International
- Publisher
- Wiley
- Published
- 1998-05
- Volume
- 48
- Issue
- 5
- Pages
- 332-340
- ISSN
- 1320-5463 (ISSN-L)
- 1440-1827
- OpenAlex
- W2055177082
- Cited by
- 73
- References
- 4
- Citations by year
- 2026: 4 · 2025: 6 · 2023: 4 · 2022: 2 · 2021: 6 · 2020: 6 · 2019: 1 · 2018: 4 · 2017: 1 · 2016: 2 · 2015: 5 · 2014: 7 · 2013: 1 · 2012: 2
- FWCI
- 1.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pathology International (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- amyloid plaques, Alzheimer's disease, amyloid fibrils, reactive astrocytes, glial fibrillary acidic protein, Congo red staining, plaque morphology, 3D reconstruction
- MeSH terms
- Aged, Alzheimer Disease, Astrocytes, Female, Glial Fibrillary Acidic Protein, Histocytochemistry, Humans, Image Processing, Computer-Assisted, Middle Aged, Amyloid beta-Peptides, Microscopy, Confocal, Cell Size, Plaque, Amyloid
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