GFAP and vimentin deficiency alters gene expression in astrocytes and microglia in wild‐type mice and changes the transcriptional response of reactive glia in mouse model for A lzheimer's disease
Open accessAbstract
Reactive astrocytes with an increased expression of intermediate filament (IF) proteins Glial Fibrillary Acidic Protein (GFAP) and Vimentin (VIM) surround amyloid plaques in Alzheimer's disease (AD). The functional consequences of this upregulation are unclear. To identify molecular pathways coupled to IF regulation in reactive astrocytes, and to study the interaction with microglia, we examined WT and APPswe/PS1dE9 (AD) mice lacking either GFAP, or both VIM and GFAP, and determined the transcriptome of cortical astrocytes and microglia from 15‐ to 18‐month‐old mice. Genes involved in lysosomal degradation (including several cathepsins) and in inflammatory response (including Cxcl5, Tlr6, Tnf, Il1b) exhibited a higher AD‐induced increase when GFAP, or VIM and GFAP, were absent. The expression of Aqp4 and Gja1 displayed the same pattern. The downregulation of neuronal support genes in astrocytes from AD mice was absent in GFAP/VIM null mice. In contrast, the absence of IFs did not affect the transcriptional alterations induced by AD in microglia, nor was the cortical plaque load altered. Visualizing astrocyte morphology in GFAP‐eGFP mice showed no clear structural differences in GFAP/VIM null mice, but did show diminished interaction of astrocyte processes with plaques. Microglial proliferation increased similarly in all AD groups. In conclusion, absence of GFAP, or both GFAP and VIM, alters AD‐induced changes in gene expression profile of astrocytes, showing a compensation of the decrease of neuronal support genes and a trend for a slightly higher inflammatory expression profile. However, this has no consequences for the development of plaque load, microglial proliferation, or microglial activation. GLIA 2015;63:1036–1056
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The consensus is that reduction in astrocyte density leads to higher amyloid levels, without changes in its aggregation or deposition.
“Therefore, it seems that the consensus is that the reduction in astrocyte density leads to higher amyloid levels, without changes in its aggregation or deposition.”
From Pharmacological ablation of astrocytes reduces Aβ degradation and synaptic connectivity in an ex vivo model of Alzheimer’s disease (2021) · cites this paper as [30]
These results reinforce the function of astrocytes regulating synapsis in AD.
“These results reinforce the function of astrocytes regulating synapsis in AD, shown by us and others [17, 43].”
From Pharmacological ablation of astrocytes reduces Aβ degradation and synaptic connectivity in an ex vivo model of Alzheimer’s disease (2021) · cites this paper as [43]
Manipulation of reactive astrocytes has resulted in improved outcomes, worse outcomes, and no change in mouse models of AD and MS.
“For example, the manipulation of reactive astrocytes has resulted in improved outcomes38,42,43, worse35 outcomes, and no change44 in mouse models of AD and MS40,45,46.”
From Reactive astrocyte nomenclature, definitions, and future directions (2021) · cites this paper as [44]
GFAP and vimentin provide mechanical sustenance for astrocyte shape and support the functional profile of reactive astrocytes through transcriptional modulation of target genes involved in astroglial and microglial responsiveness.
“which not only provide mechanical sustenance for the maintenance of astrocyte shape, but also support the functional profile of reactive astrocytes through transcriptional modulation of target genes involved in astroglial and microglial responsiveness [44, 45].”
From Gliovascular alterations in sporadic and familial Alzheimer's disease: <scp><i>APOE3</i></scp> Christchurch homozygote glioprotection (2023) · cites this paper as [44]
Vimentin and GFAP link astrocyte structure and gliovascular function, and are associated with cytoplasmic proteins participating in signal transduction pathways.
“Vimentin and GFAP link astrocyte structure and gliovascular function [90, 92], and are associated with cytoplasmic proteins [92] participating in signal transduction pathways [44, 45, 106, 107].”
From Gliovascular alterations in sporadic and familial Alzheimer's disease: <scp><i>APOE3</i></scp> Christchurch homozygote glioprotection (2023) · cites this paper as [44]
Cites
Astrocytes: Biology and pathology
Sofroniew, M. V., & Vinters, H. V. (2010) · Acta Neuropathologica · doi:10.1007/s00401-009-0619-8 · Cited by 5,196 · see citing works
Okada, S., Nakamura, M., Katoh, H., Miyao, T., Shimazaki, T., Ishii, K., Yamane, J., Yoshimura, A., Iwamoto, Y., Toyama, Y., et al. (2006) · Nature Medicine · doi:10.1038/nm1425 · Cited by 971 · see citing works
STAT3 is a Critical Regulator of Astrogliosis and Scar Formation after Spinal Cord Injury
Herrmann, J. E., Imura, T., Song, B., Qi, J., Ao, Y., Nguyen, T. K., Korsak, R. A., Takeda, K., Akira, S., & Sofroniew, M. V. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.1709-08.2008 · Cited by 958 · see citing works
Astrocyte reactivity and reactive astrogliosis: costs and benefits
Pekny, M., & Pekna, M. (2014) · Physiological Reviews · doi:10.1152/physrev.00041.2013 · Cited by 934 · see citing works
Self-citationAdult mouse astrocytes degrade amyloid-β in vitro and in situ
Wyss-Coray, T., Loike, J. D., Brionne, T. C., Lu, E., Anankov, R., Yan, F., Silverstein, S. C., & Husemann, J. (2003) · Nature Medicine · doi:10.1038/nm838 · Cited by 909 · see citing works
Integrated Brain Circuits: Astrocytic Networks Modulate Neuronal Activity and Behavior
Halassa, M. M., & Haydon, P. G. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135843 · Cited by 835 · see citing works
GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease
Jo, S., Yarishkin, O., Hwang, Y. J., Chun, Y. E., Park, M., Woo, D. H., Bae, J. Y., Kim, T., Lee, J., Chun, H., et al. (2014) · Nature Medicine · doi:10.1038/nm.3639 · Cited by 783 · see citing works
Synchronous Hyperactivity and Intercellular Calcium Waves in Astrocytes in Alzheimer Mice
Kuchibhotla, K. V., Lattarulo, C. R., Hyman, B. T., & Bacskai, B. J. (2009) · Science · doi:10.1126/science.1169096 · Cited by 729 · see citing works
The dual role of astrocyte activation and reactive gliosis
Pekny, M., Wilhelmsson, U., & Pekna, M. (2014) · Neuroscience Letters · doi:10.1016/j.neulet.2013.12.071 · Cited by 666 · see citing works
Self-citationAstrocytes Are Endogenous Regulators of Basal Transmission at Central Synapses
Panatier, A., Vallée, J., Haber, M., Murai, K. K., Lacaille, J.-C., & Robitaille, R. (2011) · Cell · doi:10.1016/j.cell.2011.07.022 · Cited by 650 · see citing works
Local Ca2+ detection and modulation of synaptic release by astrocytes
Di Castro, M. A., Chuquet, J., Liaudet, N., Bhaukaurally, K., Santello, M., Bouvier, D., Tiret, P., & Volterra, A. (2011) · Nature Neuroscience · doi:10.1038/nn.2929 · Cited by 529 · see citing works
Protective Role of Reactive Astrocytes in Brain Ischemia
Li, L., Lundkvist, A., Andersson, D., Wilhelmsson, U., Nagai, N., Pardo, A. C., Nodin, C., Ståhlberg, A., Aprico, K., Larsson, K., et al. (2008) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600546 · Cited by 505 · see citing works
Self-citationWilhelmsson, U., Li, L., Pekna, M., Berthold, C.-H., Blom, S., Eliasson, C., Renner, O., Bushong, E., Ellisman, M., Morgan, T. E., et al. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.0820-04.2004 · Cited by 455 · see citing works
Self-citationHeterogeneity of reactive astrocytes
Anderson, M. A., Ao, Y., & Sofroniew, M. V. (2013) · Neuroscience Letters · doi:10.1016/j.neulet.2013.12.030 · Cited by 449 · see citing works
Inflammatory process in Alzheimer's Disease
Meraz-Ríos, M. A., Toral-Rios, D., Franco-Bocanegra, D., Villeda-Hernández, J., & Campos-Peña, V. (2013) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2013.00059 · Cited by 427 · see citing works
Functions of Astrocytes and their Potential As Therapeutic Targets
Kimelberg, H. K., & Nedergaard, M. (2010) · Neurotherapeutics · doi:10.1016/j.nurt.2010.07.006 · Cited by 409 · see citing works
Pekny, M., Johansson, C. B., Eliasson, C., Stakeberg, J., Wallén, Å., Perlmann, T., Lendahl, U., Betsholtz, C., Berthold, C.-H., & Frisén, J. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.145.3.503 · Cited by 405 · see citing works
Self-citationShibuki, K., Gomi, H., Chen, L., Bao, S., Kim, J. J., Wakatsuki, H., Fujisaki, T., Fujimoto, K., Katoh, A., Ikeda, T., et al. (1996) · Neuron · doi:10.1016/s0896-6273(00)80078-1 · Cited by 404 · see citing works
Isolation of glia from Alzheimer’s mice reveals inflammation and dysfunction
Orre, M., Kamphuis, W., Osborn, L. M., Jansen, A. H. P., Kooijman, L., Bossers, K., & Hol, E. M. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.06.004 · Cited by 394 · see citing works
Self-citationAstrocyte phenotype in relation to Alzheimer‐type pathology in the ageing brain
Simpson, J. E., Ince, P. G., Lace, G., Forster, G., Shaw, P. J., Matthews, F., Savva, G., Brayne, C., & Wharton, S. B. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.05.015 · Cited by 381 · see citing works
Intermediate Filament Protein Partnership in Astrocytes
Eliasson, C., Sahlgren, C., Berthold, C.-H., Stakeberg, J., Celis, J. E., Betsholtz, C., Eriksson, J. E., & Pekny, M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.34.23996 · Cited by 357 · see citing works
Self-citationTargeted deletion in astrocyte intermediate filament (Gfap) alters neuronal physiology.
McCall, M. A., Gregg, R. G., Behringer, R. R., Brenner, M., Delaney, C. L., Galbreath, E. J., Zhang, C. L., Pearce, R. A., Chiu, S. Y., & Messing, A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.13.6361 · Cited by 349 · see citing works
Pekny, M., Levéen, P., Pekna, M., Eliasson, C., Berthold, C. H., Westermark, B., & Betsholtz, C. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07147.x · Cited by 336 · see citing works
Self-citationAttenuating astrocyte activation accelerates plaque pathogenesis in APP/PS1 mice
Kraft, A. W., Hu, X., Yoon, H., Yan, P., Xiao, Q., Wang, Y., Gil, S. C., Brown, J., Wilhelmsson, U., Restivo, J. L., et al. (2013) · The FASEB Journal · doi:10.1096/fj.12-208660 · Cited by 324 · see citing works
Self-citationMenet, V., Prieto, M., Privat, A., & y Ribotta, M. G. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1533187100 · Cited by 318 · see citing works
Targeting Astrocytes Ameliorates Neurologic Changes in a Mouse Model of Alzheimer's Disease
Furman, J. L., Sama, D. M., Gant, J. C., Beckett, T. L., Murphy, M. P., Bachstetter, A. D., Van Eldik, L. J., & Norris, C. M. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.2323-12.2012 · Cited by 313 · see citing works
Kamphuis, W., Mamber, C., Moeton, M., Kooijman, L., Sluijs, J. A., Jansen, A. H. P., Verveer, M., de Groot, L. R., Smith, V. D., Rangarajan, S., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042823 · Cited by 305 · see citing works
Self-citationOrre, M., Kamphuis, W., Osborn, L. M., Melief, J., Kooijman, L., Huitinga, I., Klooster, J., Bossers, K., & Hol, E. M. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.07.008 · Cited by 269 · see citing works
Self-citationMultifunctional role of astrocytes as gatekeepers of neuronal energy supply
Stobart, J. L., & Anderson, C. M. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00038 · Cited by 266 · see citing works
Xiao, Q., Yan, P., Ma, X., Liu, H., Perez, R., Zhu, A., Gonzales, E., Burchett, J. M., Schuler, D. R., Cirrito, J. R., et al. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.3788-13.2014 · Cited by 266 · see citing works
Kamphuis, W., Middeldorp, J., Kooijman, L., Sluijs, J. A., Kooi, E., Moeton, M., Freriks, M., Mizee, M. R., & Hol, E. M. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.09.035 · Cited by 244 · see citing works
Self-citationInflammatory Aspects of Alzheimer Disease and Other Neurodegenerative Disorders
Schwab, C., & McGeer, P. L. (2008) · Journal of Alzheimer s Disease · doi:10.3233/jad-2008-13402 · Cited by 234 · see citing works
Robust neural integration from retinal transplants in mice deficient in GFAP and vimentin
Kinouchi, R., Takeda, M., Yang, L., Wilhelmsson, U., Lundkvist, A., Pekny, M., & Chen, D. F. (2003) · Nature Neuroscience · doi:10.1038/nn1088 · Cited by 229 · see citing works
Self-citationBrenner, M. (2014) · Neuroscience Letters · doi:10.1016/j.neulet.2014.01.055 · Cited by 222 · see citing works
Emerging role for the cytoskeleton as an organizer and regulator of translation
Kim, S., & Coulombe, P. A. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2818 · Cited by 198 · see citing works
APP processing and amyloid deposition in mice haplo-insufficient for presenilin 1
Jankowsky, J. L., Slunt, H. H., Gonzales, V., Jenkins, N. A., Copeland, N. G., & Borchelt, D. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.09.008 · Cited by 189 · see citing works
Menet, V., y Ribotta, M. G., Chauvet, N., Drian, M.-J., Lannoy, J., Colucci‐Guyon, E., & Privat, A. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-16-06147.2001 · Cited by 181 · see citing works
Reactive glial cells: increased stiffness correlates with increased intermediate filament expression
Lu, Y., Iandiev, I., Hollborn, M., Körber, N., Ulbricht, E., Hirrlinger, P. G., Pannicke, T., Wei, E., Bringmann, A., Wolburg, H., et al. (2011) · The FASEB Journal · doi:10.1096/fj.10-163790 · Cited by 172 · see citing works
Self-citationNakazawa, T., Takeda, M., Lewis, G. P., Cho, K.-S., Jiao, J., Wilhelmsson, U., Fisher, S. K., Pekny, M., Chen, D. F., & Miller, J. W. (2007) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.06-1398 · Cited by 168 · see citing works
Self-citationIntermediate filaments regulate astrocyte motility
Lepekhin, E. A., Eliasson, C., Berthold, C., Berezin, V., Bock, E., & Pekny, M. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00595.x · Cited by 164 · see citing works
Self-citationCytoskeleton and Vesicle Mobility in Astrocytes
Potokar, M., Kreft, M., Li, L., Andersson, D., Pangršič, T., Chowdhury, H. H., Pekny, M., & Zorec, R. (2006) · Traffic · doi:10.1111/j.1600-0854.2006.00509.x · Cited by 162 · see citing works
Self-citationRoelofs, R. F., Fischer, D. F., Houtman, S. H., Sluijs, J. A., Haren, W. V., van Leeuwen, F. W., & Hol, E. M. (2005) · Glia · doi:10.1002/glia.20243 · Cited by 158 · see citing works
Self-citationHughes, E. G., Maguire, J. L., McMinn, M. T., Scholz, R. E., & Sutherland, M. L. (2004) · Molecular Brain Research · doi:10.1016/j.molbrainres.2004.02.021 · Cited by 157 · see citing works
High Susceptibility to Cerebral Ischemia in GFAP-Null Mice
Nawashiro, H., Brenner, M., Fukui, S., Shima, K., & Hallenbeck, J. M. (2000) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200007000-00003 · Cited by 141 · see citing works
Differential cell proliferation in the cortex of the appsweps1de9 alzheimer's disease mouse model
Kamphuis, W., Orre, M., Kooijman, L., Dahmen, M., & Hol, E. M. (2012) · Glia · doi:10.1002/glia.22295 · Cited by 137 · see citing works
Self-citationIntermediate Filaments as Signaling Platforms
Pallari, H., & Eriksson, J. (2006) · Science s STKE · doi:10.1126/stke.3662006pe53 · Cited by 136 · see citing works
Pekny, M., Stanness, K. A., Eliasson, C., Betsholtz, C., & Janigro, D. (1998) · PubMed · Cited by 135 · see citing works
Self-citationMechanism mediating oligomeric Aβ clearance by naïve primary microglia
Yang, C.-N., Shiao, Y.-J., Shie, F., Guo, B.-S., Chen, P.-H., Cho, C.-Y., Chen, Y., Huang, F.-L., & Tsay, H.-J. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.01.005 · Cited by 125 · see citing works
Mice lacking GFAP are hypersensitive to traumatic cerebrospinal injury
Nawashiro, H., Messing, A., Azzam, N. A., & Brenner, M. (1998) · Neuroreport · doi:10.1097/00001756-199806010-00004 · Cited by 118 · see citing works
Vardjan, N., Gabrijel, M., Potokar, M., Švajger, U., Kreft, M., Jeras, M., de Pablo, Y., Faiz, M., Pekny, M., & Zorec, R. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-144 · Cited by 117 · see citing works
Self-citationAstrocytes in Alzheimer's Disease: Emerging Roles in Calcium Dysregulation and Synaptic Plasticity
Vincent, A. J., Gasperini, R., Foa, L. C., & Small, D. H. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-101089 · Cited by 102 · see citing works
Pekny, M., Eliasson, C., Chien, C. L., Kindblom, L. G., Liem, R. K. H., Hamberger, A., & Betsholtz, C. (1998) · Experimental Cell Research · doi:10.1006/excr.1997.3922 · Cited by 102 · see citing works
Self-citationIntermediate filaments attenuate stimulation‐dependent mobility of endosomes/lysosomes in astrocytes
Potokar, M., Stenovec, M., Gabrijel, M., Li, L., Kreft, M., Grilc, S., Pekny, M., & Zorec, R. (2010) · Glia · doi:10.1002/glia.21000 · Cited by 101 · see citing works
Self-citationWidestrand, Å., Faijerson, J., Wilhelmsson, U., Smith, P. L. P., Li, L., Sihlbom, C., Eriksson, P. S., & Pekny, M. (2007) · Stem Cells · doi:10.1634/stemcells.2007-0122 · Cited by 100 · see citing works
Self-citationTemporal expression pattern of peripheral myelin protein 22 during in vivo and in vitro myelination
Notterpek, L. M., Snipes, G. J., & Shooter, E. M. (1999) · Glia · doi:10.1002/(sici)1098-1136(19990215)25:4 · Cited by 89 · see citing works
Amyloid-β Oligomers Induce Differential Gene Expression in Adult Human Brain Slices
Sebollela, A. S., Freitas-Corrêa, L., de Oliveira, F. F., Paula-Lima, A. C., Saraiva, L. M., Martins, S. M., Mota, L. D. C., Torres, C., Alves‐Leon, S. V., de Souza, J. M., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.298471 · Cited by 86 · see citing works
Ding, M., Eliasson, C., Betsholtz, C., Hamberger, A., & Pekny, M. (1998) · Molecular Brain Research · doi:10.1016/s0169-328x(98)00240-x · Cited by 84 · see citing works
Self-citationAquaporin-4-containing astrocytes sustain a temperature- and mercury-insensitive swelling in vitro
Nicchia, G. P., Frigeri, A., Liuzzi, G. M., Santacroce, M. P., Nico, B., Procino, G., Quondamatteo, F., Herken, R., Roncali, L., & Svelto, M. (2000) · Glia · doi:10.1002/(sici)1098-1136(200007)31:1 · Cited by 82 · see citing works
Astrocyte Function is Modified by Alzheimer's Disease-like Pathology in Aged Mice
Peters, O., Schipke, C. G., Philipps, A., Haas, B., Pannasch, U., Wang, L. P., Benedetti, B., Kingston, A. E., & Kettenmann, H. (2009) · Journal of Alzheimer's Disease · doi:10.3233/jad-2009-1140 · Cited by 76 · see citing works
Enhanced hippocampal neurodegeneration after traumatic or kainate excitotoxicity in GFAP-null mice
Otani, N., Nawashiro, H., Fukui, S., Ooigawa, H., Ohsumi, A., Toyooka, T., Shima, K., Gomi, H., & Brenner, M. (2006) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2005.10.018 · Cited by 73 · see citing works
Kato, S., Gondo, T., Hoshii, Y., Takahashi, M., Yamada, M., & Ishihara, T. (1998) · Pathology International · doi:10.1111/j.1440-1827.1998.tb03915.x · Cited by 73 · see citing works
Wirz, K. T. S., Bossers, K., Stargardt, A., Kamphuis, W., Swaab, D. F., Hol, E. M., & Verhaagen, J. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.11.008 · Cited by 65 · see citing works
Self-citationHavenith, C. E. G., Askew, D., & Walker, W. S. G. (1998) · Glia · doi:10.1002/(sici)1098-1136(199804)22:4 · Cited by 62 · see citing works
Self-citationMoriya, T., Yoshinobu, Y., Kouzu, Y., Katoh, A., Gomi, H., Ikeda, M., Yoshioka, T., Itohara, S., & Shibata, S. (2000) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(20000415)60:2 · Cited by 51 · see citing works
Increased astrocytic ATP release results in enhanced excitability of the hippocampus
Lee, H. U., Yamazaki, Y., Tanaka, K. F., Furuya, K., Sokabe, M., Hida, H., Takao, K., Miyakawa, T., Fujii, S., & Ikenaka, K. (2012) · Glia · doi:10.1002/glia.22427 · Cited by 49 · see citing works
Pang, Y., Cai, Z., & Rhodes, P. G. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02766-4 · Cited by 45 · see citing works
Silencing GFAP isoforms in astrocytoma cells disturbs laminin‐dependent motility and cell adhesion
Moeton, M., Kanski, R., Stassen, O. M. J. A., Sluijs, J. A., Geerts, D., van Tijn, P., Wiche, G., van Strien, M. E., & Hol, E. M. (2014) · The FASEB Journal · doi:10.1096/fj.13-245837 · Cited by 40 · see citing works
Self-citationRustay, N. R., Cronin, E. A., Curzon, P., Markosyan, S., Bitner, R. S., Ellis, T. A., Waring, J. F., Decker, M. W., Rueter, L. E., & Browman, K. E. (2009) · Brain Research · doi:10.1016/j.brainres.2009.11.040 · Cited by 38 · see citing works
A dual role for reactive astrocytes after spinal cord injury
Okada, S., Nakamura, M., Toyama, Y., Iwamoto, Y., & Okano, H. (2007) · Neuroscience Research · doi:10.1016/j.neures.2007.06.167 · Cited by 32 · see citing works
Yoshida, T., Tomozawa, Y., Arisato, T., Okamoto, Y., Hirano, H., & Nakagawa, M. (2007) · Journal of Human Genetics · doi:10.1007/s10038-007-0124-7 · Cited by 27 · see citing works
Strain specific differences in memory and neuropathology in a mouse model of Alzheimer's disease
Glazner, K. A. C., Odero, G. L., Anema, E., Motnenko, A., Schapansky, J., Grossman, D., Oliver, D. R., Glazner, G. W., & Albensi, B. C. (2010) · Life Sciences · doi:10.1016/j.lfs.2010.04.014 · Cited by 25 · see citing works
Bossers, K., Ylstra, B., Brakenhoff, R. H., Smeets, S. J., Verhaagen, J., & van de Wiel, M. A. (2010) · BMC Genomics · doi:10.1186/1471-2164-11-112 · Cited by 17 · see citing works
Genetic Regulatory Network Analysis forAppBased on Genetical Genomics Approach
Wang, X., Chen, Y., Wang, X., & Lu, L. (2009) · Experimental Aging Research · doi:10.1080/03610730903418729 · Cited by 16 · see citing works
Nolte (2001) · doi:10.1002/1098-1136(20010101)33:1
Flagged first, then by citations
Cited by
Sorted by citations
Reactive astrocyte nomenclature, definitions, and future directions
Escartin, C., Galea, E., Lakatos, A., O’Callaghan, J. P., Petzold, G. C., Serrano-Pozo, A., Steinhäuser, C., Volterra, A., Carmignoto, G., Agarwal, A., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-020-00783-4 · Cited by 2,533 · see citing works
Self-citationThe Cellular Phase of Alzheimer’s Disease
De Strooper, B., & Karran, E. (2016) · Cell · doi:10.1016/j.cell.2015.12.056 · Cited by 1,990 · see citing works
Single-cell profiling of the developing mouse brain and spinal cord with split-pool barcoding
Rosenberg, A. B., Roco, C. M., Muscat, R. A., Kuchina, A., Sample, P., Yao, Z., Graybuck, L. T., Peeler, D. J., Mukherjee, S., Chen, W., et al. (2018) · Science · doi:10.1126/science.aam8999 · Cited by 1,422 · see citing works
Astrocytes: a central element in neurological diseases
Pekny, M., Pekna, M., Messing, A., Steinhäuser, C., Lee, J., Parpura, V., Hol, E. M., Sofroniew, M. V., & Verkhratsky, A. (2015) · Acta Neuropathologica · doi:10.1007/s00401-015-1513-1 · Cited by 755 · see citing works
Self-citationAstrocyte Reactivity: Subtypes, States, and Functions in CNS Innate Immunity
Sofroniew, M. V. (2020) · Trends in Immunology · doi:10.1016/j.it.2020.07.004 · Cited by 721 · see citing works
Elusive roles for reactive astrocytes in neurodegenerative diseases
Ben Haim, L., Carrillo-de Sauvage, M.-A., Ceyzériat, K., & Escartin, C. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00278 · Cited by 453 · see citing works
Astrocytes in human central nervous system diseases: a frontier for new therapies
Verkhratsky, A., Butt, A., Li, B., Illes, P., Zorec, R., Semyanov, A., Tang, Y., & Sofroniew, M. V. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01628-9 · Cited by 428 · see citing works
Reactive astrocytes in neurodegenerative diseases
Li, K., Li, J., Zheng, J., & Qin, S. (2019) · Aging and disease · doi:10.14336/ad.2018.0720 · Cited by 398 · see citing works
Astrogliosis: An integral player in the pathogenesis of Alzheimer's disease
Osborn, L. M., Kamphuis, W., Wadman, W. J., & Hol, E. M. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.01.001 · Cited by 312 · see citing works
Self-citationDeciphering the astrocyte reaction in Alzheimer's disease
Perez-Nievas, B. G., & Serrano-Pozo, A. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00114 · Cited by 282 · see citing works
Chun, H., Im, H., Kang, Y. J., Kim, Y., Shin, J. H., Won, W., Lim, J., Ju, Y. H., Park, Y. M., Kim, S., et al. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-00735-y · Cited by 274 · see citing works
Reactive gliosis in the pathogenesis of CNS diseases
Pekny, M., & Pekna, M. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.11.014 · Cited by 276 · see citing works
Self-citationRoles of vimentin in health and diseasePreprint
Ridge, K. M., Eriksson, J., Pekny, M., & Goldman, R. D. (2022) · Genes & Development · doi:10.1101/gad.349358.122 · Cited by 256 · see citing works
Self-citationCeyzériat, K., Ben Haim, L., Denizot, A., Pommier, D., Matos, M., Guillemaud, O., Palomares, M.-A., Abjean, L., Petit, F., Gipchtein, P., et al. (2018) · Acta Neuropathologica Communications · doi:10.1186/s40478-018-0606-1 · Cited by 256 · see citing works
Baik, S. H., Kang, S., Son, S. M., & Mook-Jung, I. (2016) · Glia · doi:10.1002/glia.23074 · Cited by 234 · see citing works
Kamphuis, W., Kooijman, L., Schetters, S., Orre, M., & Hol, E. M. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.07.007 · Cited by 209 · see citing works
Self-citationIorio, R., Damato, V., Evoli, A., Gessi, M., Gaudino, S., Lazzaro, V. D., Spagni, G., Sluijs, J. A., & Hol, E. M. (2017) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2017-316583 · Cited by 209 · see citing works
Self-citationReactive astrocytes: The nexus of pathological and clinical hallmarks of Alzheimer’s disease
Price, B. R., Johnson, L. A., & Norris, C. M. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101335 · Cited by 173 · see citing works
Reactive astrocytes in Alzheimer’s disease: A double-edged sword
Chun, H., & Lee, C. J. (2018) · Neuroscience Research · doi:10.1016/j.neures.2017.11.012 · Cited by 176 · see citing works
Divergent transcriptional regulation of astrocyte reactivity across disorders
Burda, J. E., O’Shea, T. M., Ao, Y., Suresh, K. B., Wang, S., Bernstein, A. M., Chandra, A., Deverasetty, S., Kawaguchi, R., Kim, J. H., et al. (2022) · Nature · doi:10.1038/s41586-022-04739-5 · Cited by 164 · see citing works
The amyloid plaque proteome in early onset Alzheimer’s disease and Down syndrome
Drummond, E., Kavanagh, T., Pires, G., Marta-Ariza, M., Kanshin, E., Nayak, S., Faustin, A., Berdah, V., Ueberheide, B., & Wisniewski, T. (2022) · Acta Neuropathologica Communications · doi:10.1186/s40478-022-01356-1 · Cited by 137 · see citing works
Microglial priming of antigen presentation and adaptive stimulation in Alzheimer’s disease
Das, R., & Chinnathambi, S. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03132-2 · Cited by 147 · see citing works
Hol, E. M., & Capetanaki, Y. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a021642 · Cited by 144 · see citing works
Self-citationAstroglial atrophy in Alzheimer’s disease
Verkhratsky, A., Rodriguez, J. J., Pivoriūnas, A., Zorec, R., & Semyanov, A. V. (2019) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-019-02310-2 · Cited by 140 · see citing works
Research Progress in the Pathogenesis of Alzheimer's Disease
Chen, Y. (2018) · Chinese Medical Journal · doi:10.4103/0366-6999.235112 · Cited by 139 · see citing works
Cross‐talk between monocyte invasion and astrocyte proliferation regulates scarring in brain injury
Frik, J., Merl‐Pham, J., Plesnila, N., Mattugini, N., Kjell, J., Kraska, J., Gomez, R. M., Hauck, S. M., Sirko, S., & Götz, M. (2018) · EMBO Reports · doi:10.15252/embr.201745294 · Cited by 126 · see citing works
Neurovascular Coupling in Development and Disease: Focus on Astrocytes
Stackhouse, T. L., & Mishra, A. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.702832 · Cited by 124 · see citing works
Diversity of astroglial responses across human neurodegenerative disorders and brain aging
Ferrer, I. (2017) · Brain Pathology · doi:10.1111/bpa.12538 · Cited by 123 · see citing works
Messing, A., & Brenner, M. (2020) · ASN NEURO · doi:10.1177/1759091420949680 · Cited by 120 · see citing works
The Many Faces of Astrocytes in Alzheimer's Disease
Monterey, M. D., Wei, H., Wu, X., & Wu, J. Q. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.619626 · Cited by 117 · see citing works
Toxoplasma Modulates Signature Pathways of Human Epilepsy, Neurodegeneration & Cancer
Ngô, H. M., Zhou, Y., Lorenzi, H., Wang, K., Kim, T., Zhou, Y. F., Bissati, K. E., Mui, E. J., Fraczek, L., Rajagopala, S. V., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-10675-6 · Cited by 113 · see citing works
Scuderi, S. A., Ardizzone, A., Paterniti, I., Esposito, E., & Campolo, M. (2020) · Antioxidants · doi:10.3390/antiox9070630 · Cited by 114 · see citing works
Incipient Melanoma Brain Metastases Instigate Astrogliosis and Neuroinflammation
Doron, H., Blacher, E., Amer, M., Livneh, N., Abramovitz, L., Klein, A., Ben‐Shushan, D., Soffer, S., Blazquez, R., Barrantes‐Freer, A., et al. (2016) · Cancer Research · doi:10.1158/0008-5472.can-16-0485 · Cited by 107 · see citing works
Reid, M. J., Beltran-Lobo, P., Johnson, L., Perez‐Nievas, B. G., & Noble, W. J. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.572850 · Cited by 92 · see citing works
Sun, P., Jun-bo, Y., Liu, L., Guo, J., Wang, S.-H., Qu, C., & Wang, C.-X. (2018) · Bioscience Reports · doi:10.1042/bsr20180902 · Cited by 89 · see citing works
Ablation of reactive astrocytes exacerbates disease pathology in a model of Alzheimer's disease
Katsouri, L., Birch, A. M., Renziehausen, A. W. J., Zach, C., Aman, Y., Steeds, H., Bonsu, A., Palmer, E. O. C., Mirzaei, N., Ries, M., et al. (2020) · Glia · doi:10.1002/glia.23759 · Cited by 81 · see citing works
Qiao, J., Wang, J., Wang, H., Zhang, Y., Zhu, S., Adilijiang, A., Guo, H., Zhang, R., Guo, W., Luo, G., et al. (2015) · Glia · doi:10.1002/glia.22926 · Cited by 80 · see citing works
Merlo, S., Spampinato, S. F., & Sortino, M. A. (2018) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13050 · Cited by 78 · see citing works
Das, S., Li, Z., Noori, A., Hyman, B. T., & Serrano-Pozo, A. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01898-y · Cited by 80 · see citing works
Vimentin as a potential target for diverse nervous system diseases
Wang, T., Qiu, X., Wu, H., Chen, K., Liu, S., Li, Y., He, T., & Zhao, J. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.355744 · Cited by 77 · see citing works
Identification of Conserved Proteomic Networks in Neurodegenerative Dementia
Swarup, V., Chang, T. S., Duong, D. M., Dammer, E. B., Dai, J., Lah, J. J., Johnson, E. C. B., Seyfried, N. T., Levey, A. I., & Geschwind, D. H. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107807 · Cited by 78 · see citing works
Identification of conserved proteomic networks in neurodegenerative dementia
Swarup, V., Chang, T. S., Duong, D. M., Dammer, E. B., Lah, J. J., Johnson, E. E. C. B., Seyfried, N. T., Levey, A. I., & Geschwind, D. H. (2019) · doi:10.1101/825802 · Cited by 78 · see citing works
Chun, H., Marriott, I., Lee, C. J., & Cho, H. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00797 · Cited by 77 · see citing works
Exosomal MicroRNAs Released by Activated Astrocytes as Potential Neuroinflammatory Biomarkers
Gayen, M., Bhomia, M., Balakathiresan, N. S., & Knollmann-Ritschel, B. E. C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072312 · Cited by 76 · see citing works
Multiple inflammatory profiles of microglia and altered neuroimages in APP/PS1 transgenic AD mice
Liu, L., Liu, Y., Li, N., Huang, R., Zheng, X., Huang, L., Hou, S.-X., & Yuan, Q. (2020) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2020.01.003 · Cited by 70 · see citing works
Smit, T., Deshayes, N. A. C., Borchelt, D. R., Kamphuis, W., Middeldorp, J., & Hol, E. M. (2021) · Glia · doi:10.1002/glia.23981 · Cited by 71 · see citing works
Self-citationThe role of GFAP and vimentin in learning and memory
Wilhelmsson, U., Pozo-Rodrigálvarez, A., Kalm, M., de Pablo, Y., Widestrand, Å., Pekna, M., & Pekny, M. (2019) · Biological Chemistry · doi:10.1515/hsz-2019-0199 · Cited by 64 · see citing works
Self-citationDavis, N., Mota, B. C., Stead, L., Palmer, E. O. C., Lombardero, L., Rodríguez-Puertas, R., de Paola, V., Barnes, S. J., & Sastre, M. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02117-y · Cited by 65 · see citing works
The Role of Astrocytes in Synapse Loss in Alzheimer's Disease: A Systematic Review
Hulshof, L. A., van Nuijs, D., Hol, E. M., & Middeldorp, J. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.899251 · Cited by 63 · see citing works
Self-citationTargeting MAPK phosphorylation of Connexin43 provides neuroprotection in stroke
Andrade, M. F., Wang, N., Bechberger, J. F., Bock, M. D., Lampe, P. D., Leybaert, L., & Naus, C. C. G. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20171452 · Cited by 64 · see citing works
Su, L., Chen, S., Zheng, C., Wei, H., & Song, X. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00633 · Cited by 59 · see citing works
Yang, Y., Ren, J., Sun, Y., Xue, Y., Zhang, Z., Gong, A., Wang, B., Zhong, Z., Cui, Z., Xi, Z., et al. (2018) · Cell Death and Differentiation · doi:10.1038/s41418-018-0137-0 · Cited by 55 · see citing works
Jurcău, A. (2021) · Nutrients · doi:10.3390/nu13020282 · Cited by 55 · see citing works
The role of Locus Coeruleus in neuroinflammation occurring in Alzheimer’s disease
Giorgi, F. S., Saccaro, L. F., Galgani, A., Busceti, C. L., Biagioni, F., Frati, A., & Fornai, F. (2019) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2019.08.007 · Cited by 53 · see citing works
Chen, X., Liang, H., Xi, Z., Yang, Y., Shan, H., Wang, B., Zhong, Z., Xu, C., Yang, G., Sun, Q., et al. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00302 · Cited by 50 · see citing works
Wyatt-Johnson, S. K., & Brutkiewicz, R. R. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.592359 · Cited by 50 · see citing works
Glial Purinergic Signaling in Neurodegeneration
Pietrowski, M. J., Gabr, A. A., Kozlov, S. O., Blum, D. L., Halle, A., & Carvalho, K. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.654850 · Cited by 47 · see citing works
Katsipis, G., Tzekaki, E. E., Tsolaki, M., & Pantazaki, Α. A. (2021) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2021.577744 · Cited by 47 · see citing works
McKee, C. A., Lee, J., Cai, Y., Saito, T., Saido, T. C., & Musiek, E. S. (2022) · Scientific Reports · doi:10.1038/s41598-022-05862-z · Cited by 45 · see citing works
Heterogeneity of Notch signaling in astrocytes and the effects of GFAP and vimentin deficiency
Lebkuechner, I., Wilhelmsson, U., Möllerström, E., Pekna, M., & Pekny, M. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13213 · Cited by 43 · see citing works
Self-citationAdult Astrogenesis and the Etiology of Cortical Neurodegeneration
Mohn, T. C., & Koob, A. O. (2015) · Journal of Experimental Neuroscience · doi:10.4137/jen.s25520 · Cited by 42 · see citing works
Yang, J., Zhang, R., Shi, C., Mao, C., Yang, Z.-H., Suo, Z., Torp, R., & Xu, Y. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-160957 · Cited by 42 · see citing works
A2AR‐induced transcriptional deregulation in astrocytes: An in vitro study
Paiva, I., Carvalho, K., Santos, P. I., Cellai, L., Pavlou, M. A. S., Jain, G., Gnad, T., Pfeifer, A., Vieau, D., Fischer, A., et al. (2019) · Glia · doi:10.1002/glia.23688 · Cited by 38 · see citing works
Wilhelmsson, U., Andersson, D., de Pablo, Y., Pekny, R., Ståhlberg, A., Mulder, J., Mitsios, N., Hortobágyi, T., Pekny, M., & Pekna, M. (2017) · Cerebral Cortex · doi:10.1093/cercor/bhx069 · Cited by 38 · see citing works
Self-citationProteomic approach for understanding milder neurotoxicity of Carfilzomib against Bortezomib
Karademir-Yilmaz, B., Sarı, G., Jannuzzi, A. T., Musunuri, S., Wicher, G., Grune, T., Mi, J., Bay, H. H., Forsberg‐Nilsson, K., Bergquist, J., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-34507-3 · Cited by 32 · see citing works
Vimentin is required for normal accumulation of body fat
Wilhelmsson, U., Stillemark-Billton, P., Borén, J., & Pekny, M. (2019) · Biological Chemistry · doi:10.1515/hsz-2019-0170 · Cited by 29 · see citing works
Self-citationBandara, E. M. S., Asih, P. R., Pedrini, S., Hone, E., Fernando, W. M. A. D. B., & Martins, R. N. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05219-3 · Cited by 33 · see citing works
Xie, Z., Yang, Q., Song, D. F., Quan, Z., & Qing, H. (2019) · Glia · doi:10.1002/glia.23693 · Cited by 29 · see citing works
Han, K. H., Arlian, B. M., Macauley, M. S., Paulson, J. C., & Lerner, R. A. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1719259115 · Cited by 28 · see citing works
Genetic targeting of astrocytes to combat neurodegenerative disease
Kirschen, G., Kéry, R., & Chen, A. F. (2019) · Neural Regeneration Research · doi:10.4103/1673-5374.265541 · Cited by 28 · see citing works
Chen, X., Xu, C., Liang, H., Xi, Z., Pan, J., Yang, Y., Sun, Q., Yang, G., Sun, Y., & Bian, L. (2020) · Aging · doi:10.18632/aging.103025 · Cited by 28 · see citing works
The astroglial and stem cell functions of adult rat folliculostellate cells
Fletcher, P. A., Smiljanić, K., Prévide, R. M., Constantin, S., Sherman, A., Coon, S. L., & Stojilković, S. S. (2022) · Glia · doi:10.1002/glia.24267 · Cited by 28 · see citing works
Crystal structure of the human glial fibrillary acidic protein 1B domain
Kim, B., Kim, S., & Jin, M. S. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.08.066 · Cited by 28 · see citing works
Attilio, P. J., Snapper, D. M., Rusnak, M., Isaac, A. J., Soltis, A. R., Wilkerson, M. D., Dalgard, C. L., & Symes, A. J. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.636259 · Cited by 25 · see citing works
Kijewska, M., Viski, C., Turrell, F. K., Fitzpatrick, A., van Weverwijk, A., Gao, Q., Iravani, M., & Isacke, C. M. (2019) · Breast Cancer Research · doi:10.1186/s13058-018-1093-9 · Cited by 25 · see citing works
Yu, Q.-S., Feng, W.-Q., Shi, L., Niu, R., & Liu, J. (2022) · Brain Sciences · doi:10.3390/brainsci12081022 · Cited by 23 · see citing works
Vimentin Phosphorylation Is Required for Normal Cell Division of Immature Astrocytes
de Pablo, Y., Marášek, P., Pozo-Rodrigálvarez, A., Wilhelmsson, U., Inagaki, M., Pekna, M., & Pekny, M. (2019) · Cells · doi:10.3390/cells8091016 · Cited by 23 · see citing works
Self-citationGenetic Constructs for the Control of Astrocytes’ Activity
Borodinova, A. A., Balaban, P. M., Борисович, Б. И., Salmina, A. B., & Власова, О. Л. (2021) · Cells · doi:10.3390/cells10071600 · Cited by 22 · see citing works
Principles of Astrogliopathology
Verkhratsky, A., Li, B., Scuderi, C., & Parpura, V. (2021) · Advances in Neurobiology · doi:10.1007/978-3-030-77375-5_3 · Cited by 21 · see citing works
Lessons from Animal Models of Cytoplasmic Intermediate Filament Proteins
Bouameur, J.-E., & Magin, T. M. (2017) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-319-49674-0_7 · Cited by 21 · see citing works
Activation of PKC triggers rescue of NPC1 patient specific iPSC derived glial cells from gliosis
Peter, F., Rost, S., Rolfs, A., & Frech, M. J. (2017) · Orphanet Journal of Rare Diseases · doi:10.1186/s13023-017-0697-y · Cited by 19 · see citing works
Singhaarachchi, P. H., Antal, P., Calon, F., Culmsee, C., Delpech, J.-C., Feldotto, M., Geertsema, J., Hoeksema, E. E., Kőrösi, A., Layé, S., et al. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105724 · Cited by 18 · see citing works
Ceyzériat, K., Badina, A. M., Petrelli, F., Montessuit, S., Nicolaides, A., Millet, P., Savioz, A., Martinou, J.-C., & Tournier, B. B. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106623 · Cited by 18 · see citing works
Tolédano, A., Rodríguez‐Casado, A., Álvarez, M., & Toledano‐Díaz, A. (2024) · Brain Sciences · doi:10.3390/brainsci14111101 · Cited by 19 · see citing works
Wang, D., Zhang, X., Wang, M., Zhou, D., Pan, H., Shu, Q., & Sun, B. (2018) · Neuroscience Bulletin · doi:10.1007/s12264-018-0262-2 · Cited by 17 · see citing works
Podvin, S., Jones, A. C., Liu, Q., Aulston, B. D., Mosier, C., Ames, J., Winston, C. N., Lietz, C. B., Jiang, Z., O’Donoghue, A. J., et al. (2021) · ACS Omega · doi:10.1021/acsomega.1c00660 · Cited by 16 · see citing works
Smit, T., Ormel, P. R., Sluijs, J. A., Hulshof, L. A., Middeldorp, J., de Witte, L. D., Hol, E. M., & Donega, V. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.12.001 · Cited by 16 · see citing works
Self-citationZhang, Q., Lou, Y., Fang, H., Sun, S., Jin, R., Ji, Y., & Chen, Z. (2024) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2024.12438 · Cited by 16 · see citing works
Behroozi, Z., Rahimi, B., Motamednezhad, A., Ghadaksaz, A., Hormozi‐Moghaddam, Z., Moshiri, A., Jafarpour, M., Hajimirzaei, P., Ataie, A., & Janzadeh, A. (2024) · Photochemical & Photobiological Sciences · doi:10.1007/s43630-023-00501-6 · Cited by 14 · see citing works
Mirzaei, N., Mota, B. C., Birch, A. M., Davis, N., Romero‐Molina, C., Katsouri, L., Palmer, E. O. C., Golbano, A., Riggall, L. J., Nagy, I., et al. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15312 · Cited by 15 · see citing works
Luca, C. D., Virtuoso, A., Korai, S. A., Cirillo, R., Gargano, F., Papa, M., & Cirillo, G. (2022) · Cells · doi:10.3390/cells11071224 · Cited by 14 · see citing works
Wendt, S., Lin, A. J., Ebert, S. N., Brennan, D. J., Cai, W., Bai, Y., Kong, D. Y., Sorrentino, S., Groten, C. J., Lee, C., et al. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03433-3 · Cited by 13 · see citing works
JOTROL, a Novel Formulation of Resveratrol, Shows Beneficial Effects in the 3xTg-AD Mouse Model1
Dennison, J. L., Volmar, C., Modarresi, F., Ke, D., Wang, J., Gravel, E., Vignini-Hammond, S., Li, Z., Timmons, J. A., Lohse, I., et al. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-215370 · Cited by 13 · see citing works
Astrocyte Reactivity in Alzheimer’s Disease: Therapeutic Opportunities to Promote Repair
Mirzaei, N., Davis, N., Chau, T. W., & Sastre, M. (2021) · Current Alzheimer Research · doi:10.2174/1567205018666211029164106 · Cited by 11 · see citing works
Henao‐Restrepo, J., López‐Murillo, C., Valderrama‐Carmona, P., Orozco‐Santa, N., Gomez, J., Gutiérrez‐Vargas, J., Moraga, R., Toledo, J., Littau, J. L., Härtel, S., et al. (2023) · Brain Pathology · doi:10.1111/bpa.13119 · Cited by 11 · see citing works
An interpretable deep learning framework identifies proteomic drivers of Alzheimer’s disease
Panizza, E., & Cerione, R. A. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1379984 · Cited by 11 · see citing works
Amaral, A. U., Seminotti, B., da Silva, J. C., de Oliveira, F. H., Ribeiro, R. T., Vargas, C. R., Leipnitz, G., Santamarı́a, A., Souza, D. O., & Wajner, M. (2017) · Neurotoxicity Research · doi:10.1007/s12640-017-9848-0 · Cited by 11 · see citing works
Toledano‐Díaz, A., Álvarez, M., & Tolédano, A. (2022) · Journal of Central Nervous System Disease · doi:10.1177/11795735221128703 · Cited by 11 · see citing works
Ise, H., Yamasaki, S., Sueyoshi, K., & Miura, Y. (2017) · Genes to Cells · doi:10.1111/gtc.12535 · Cited by 11 · see citing works
Optogenetics in Alzheimer’s Disease: Focus on Astrocytes
Mitroshina, Е. V., Kalinina, E. P., & Vedunova, M. V. (2023) · Antioxidants · doi:10.3390/antiox12101856 · Cited by 10 · see citing works
- Authors
- Kamphuis, W., Kooijman, L., Orre, M., Stassen, O., Pekny, M., & Hol, E. M.
- Affiliations
- Netherlands Institute for Neuroscience (NL)
- Karolinska Institutet (SE)
- Florey Institute of Neuroscience and Mental Health (AU)
- Corresponding author
- Kamphuis, Willem
- Venue
- Glia
- Publisher
- Wiley
- Published
- 2015-03-02
- Volume
- 63
- Issue
- 6
- Pages
- 1036-1056
- ISSN
- 0894-1491 (ISSN-L)
- 1098-1136
- OpenAlex
- W1925771428
- Cited by
- 155
- References
- 74
- Citations by year
- 2026: 6 · 2025: 14 · 2024: 12 · 2023: 13 · 2022: 17 · 2021: 20 · 2020: 17 · 2019: 16 · 2018: 17 · 2017: 11 · 2016: 5 · 2015: 7
- FWCI
- 9.82
- Type
- journal article
- Language
- en
- Open access
- green
- dspace.library.uu.nl
- Licence
- Locations
- Glia (publishedVersion)
- PubMed (publishedVersion)
- UvA-DARE (University of Amsterdam) (publishedVersion)
- KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (publishedVersion)
- TU/e Research Portal (publishedVersion)
- TU/e Research Portal (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
- Åbo Akademi University Research Portal (submittedVersion)
- Utrecht University Repository (Utrecht University) (submittedVersion)
- NOVA (University of Newcastle Australia) (submittedVersion)
- Funders
- AFA Research Foundation, ALF Göteborg (project 11392)
- EU FP 7 Program TargetBraIn (project 279017)
- Internationale Stichting Alzheimer Onderzoek (ISAO 08504/12509)
- Netherlands Organization for Scientific Research (VICI grant 865.09.003 to E.M.H.)
- Swedish Medical Research Council (project 11548)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- Alzheimer's disease, glial fibrillary acidic protein, vimentin, intermediate filaments, astrocytes, microglia, reactive glia, APP/PS1 mice, amyloid plaques, transcriptome, lysosomal degradation, cathepsins, neuroinflammation, aquaporin-4, connexin 43, astrocyte-microglia interaction, microglial proliferation
- MeSH terms
- Aged, Alzheimer Disease, Animals, Astrocytes, Brain, Disease Models, Animal, Glial Fibrillary Acidic Protein, Humans, Male, Mice, Inbred C57BL, Mice, Transgenic, Vimentin, Gene Expression, Amyloid beta-Protein Precursor, Microglia, Cell Proliferation, Green Fluorescent Proteins, Presenilin-1, Chemokine CXCL5, Mice, 129 Strain
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
