Therapeutic effects of glatiramer acetate and grafted CD115+monocytes in a mouse model of Alzheimer’s disease
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Weekly glatiramer acetate immunization of transgenic mice modelling Alzheimer's disease resulted in retained cognition (Morris water maze test), decreased amyloid-β plaque burden, and regulation of local inflammation through a mechanism involving enhanced recruitment of monocytes. Ablation of bone marrow-derived myeloid cells exacerbated plaque pathology, whereas weekly administration of glatiramer acetate enhanced cerebral recruitment of innate immune cells, which dampened the pathology. Here, we assessed the therapeutic potential of grafted CD115(+) monocytes, injected once monthly into the peripheral blood of transgenic APPSWE/PS1ΔE9 Alzheimer's disease mouse models, with and without weekly immunization of glatiramer acetate, as compared to glatiramer acetate alone. All immune-modulation treatment groups were compared with age-matched phosphate-buffered saline-injected control transgenic and untreated non-transgenic mouse groups. Two independent cohorts of mice were assessed for behavioural performance (6-8 mice/group); treatments started in 10-month-old symptomatic mice and spanned a total of 2 months. For all three treatments, our data suggest a substantial decrease in cognitive deficit as assessed by the Barnes maze test (P < 0.0001-0.001). Improved cognitive function was associated with synaptic preservation and reduction in cerebral amyloid-β protein levels and astrogliosis (P < 0.001 and P < 0.0001), with no apparent additive effects for the combined treatment. The peripherally grafted, green fluorescent protein-labelled and endogenous monocytes, homed to cerebral amyloid plaques and directly engulfed amyloid-β; their recruitment was further enhanced by glatiramer acetate. In glatiramer acetate-immunized mice and, moreover, in the combined treatment group, monocyte recruitment to the brain was coupled with greater elevation of the regulatory cytokine IL10 surrounding amyloid-β plaques. All treated transgenic mice had increased cerebral levels of MMP9 protein (P < 0.05), an enzyme capable of degrading amyloid-β, which was highly expressed by the infiltrating monocytes. In vitro studies using primary cultures of bone marrow monocyte-derived macrophages, demonstrated that glatiramer acetate enhanced the ability of macrophages to phagocytose preformed fibrillar amyloid-β1-42 (P < 0.0001). These glatiramer acetate-treated macrophages exhibited increased expression of the scavenger receptors CD36 and SCARA1 (encoded by MSR1), which can facilitate amyloid-β phagocytosis, and the amyloid-β-degrading enzyme MMP9 (P < 0.0001-0.001). Overall, our studies indicate that increased cerebral infiltration of monocytes, either by enrichment of their levels in the circulation or by weekly immunization with glatiramer acetate, resulted in substantial attenuation of disease progression in murine Alzheimer's models by mechanisms that involved enhanced cellular uptake and enzymatic degradation of toxic amyloid-β as well as regulation of brain inflammation.
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Monocyte enrichment increases monocyte infiltration in the brain, resulting in engulfment of Aβ deposits.
“monocyte enrichment increases monocyte infiltration in the brain, resulting in the engulfment of Aβ deposits.434”
From Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances (2025) · cites this paper as [434]
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The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics
Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864 · see citing works
Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy
Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359 · see citing works
Polazzi, E., Mengoni, I., Caprini, M., Peña‐Altamira, E., Kurtys, E., & Monti, B. (2012) · Neurosignals · doi:10.1159/000337115 · Cited by 9,023 · see citing works
Inflammation and Alzheimer’s disease
Akiyama, H. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00124-x · Cited by 4,514 · see citing works
Monocyte Chemoattractant Protein-1 (MCP-1): An Overview
Deshmane, S. L., Kremlev, S., Amini, S., & Sawaya, B. E. (2009) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2008.0027 · Cited by 3,889 · see citing works
Shankar, G. M., Li, S., Mehta, T. H., Garcia-Munoz, A., Shepardson, N. E., Smith, I., Brett, F. M., Farrell, M. A., Rowan, M. J., Lemere, C. A., et al. (2008) · Nature Medicine · doi:10.1038/nm1782 · Cited by 3,685 · see citing works
Self-citationDecreased Clearance of CNS β-Amyloid in Alzheimer’s Disease
Mawuenyega, K. G., Sigurdson, W., Ovod, V., Munsell, L., Kasten, T., Morris, J. C., Yarasheski, K. E., & Bateman, R. J. (2010) · Science · doi:10.1126/science.1197623 · Cited by 2,078 · see citing works
Jankowsky, J. L., Fadale, D. J., Anderson, J., Xu, G. M., Gonzales, V., Jenkins, N. A., Copeland, N. G., Lee, M. K., Younkin, L. H., Wagner, S. L., et al. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh019 · Cited by 1,575 · see citing works
Microglial Dysfunction and Defective β-Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice
Hickman, S. E., Allison, E. K., & El Khoury, J. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.0616-08.2008 · Cited by 1,329 · cited 20× · see citing works
“Representative images show that increased fibrillar amyloid-b1–42 uptake following GA treatment was coupled with increased expression of the class B scavenger receptor CD36 (Fig.”
BackgroundInfluentialWyss-Coray (2006) · doi:10.1038/nm1484 · Cited by 1,284 · see citing works
Simard, A. R., Soulet, D., Gowing, G., Julien, J.-P., & Rivest, S. (2006) · Neuron · doi:10.1016/j.neuron.2006.01.022 · Cited by 1,265 · see citing works
Inflammation in Neurodegenerative Disease—A Double-Edged Sword
Wyss-Coray, T., & Mucke, L. (2002) · Neuron · doi:10.1016/s0896-6273(02)00794-8 · Cited by 1,235 · see citing works
Soluble oligomers of the amyloid β-protein impair synaptic plasticity and behavior
Selkoe, D. J. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.02.016 · Cited by 1,038 · see citing works
El Khoury, J., Toft, M., Hickman, S. E., Means, T. K., Terada, K., Geula, C., & Luster, A. D. (2007) · Nature Medicine · doi:10.1038/nm1555 · Cited by 915 · see citing works
Co-expression of multiple transgenes in mouse CNS: a comparison of strategies
Jankowsky, J. L., Slunt, H. H., Ratovitski, T., Jenkins, N. A., Copeland, N. G., & Borchelt, D. (2001) · Biomolecular Engineering · doi:10.1016/s1389-0344(01)00067-3 · Cited by 819 · see citing works
Shechter, R., London, A., Varol, C., Raposo, C., Cusimano, M., Yovel, G., Rolls, A., Mack, M., Pluchino, S., Martino, G., et al. (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000113 · Cited by 770 · see citing works
Heterogeneity of CNS myeloid cells and their roles in neurodegeneration
Prinz, M., Priller, J., Sisodia, S. S., & Ransohoff, R. M. (2011) · Nature Neuroscience · doi:10.1038/nn.2923 · Cited by 674 · see citing works
Koronyo-Hamaoui, M., Koronyo, Y., Ljubimov, A. V., Miller, C. A., Ko, M. K., Black, K. L., Schwartz, M., & Farkas, D. L. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2010.06.020 · Cited by 672 · see citing works
Self-citationParesce, D. M., Ghosh, R. N., & Maxfield, F. R. (1996) · Neuron · doi:10.1016/s0896-6273(00)80187-7 · Cited by 663 · see citing works
Characterization of the Drosophila melanogaster genome at the nuclear lamina
Pickersgill, H., Kalverda, B., de Wit, E., Talhout, W., Fornerod, M., & van Steensel, B. (2006) · Nature Genetics · doi:10.1038/ng1852 · Cited by 656 · see citing works
Ford, A. L., Goodsall, A. L., Hickey, W. F., & Sedgwick, J. D. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.154.9.4309 · Cited by 631 · see citing works
Monocytes give rise to mucosal, but not splenic, conventional dendritic cells
Varol, C., Landsman, L., Fogg, D. K., Greenshtein, L., Gildor, B., Margalit, R., Kalchenko, V., Geissmann, F., & Jung, S. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20061011 · Cited by 627 · see citing works
TGF-β1 promotes microglial amyloid-β clearance and reduces plaque burden in transgenic mice
Wyss-Coray, T., Lin, C., Yan, F., Yu, G.-Q., Rohde, M., McConlogue, L., Masliah, E., & Mucke, L. (2001) · Nature Medicine · doi:10.1038/87945 · Cited by 587 · see citing works
Izikson, L., Klein, R. S., Charo, I. F., Weiner, H. L., & Luster, A. D. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.7.1075 · Cited by 584 · see citing works
Type II monocytes modulate T cell–mediated central nervous system autoimmune disease
Weber, M. S., Prod'homme, T., Youssef, S., Dunn, S. E., Rundle, C. D., Lee, L., Patarroyo, J. C., Stüve, O., Sobel, R. A., Steinman, L., et al. (2007) · Nature Medicine · doi:10.1038/nm1620 · Cited by 447 · see citing works
Hawkes, C. A., & McLaurin, J. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805453106 · Cited by 397 · see citing works
Butovsky, O., Koronyo-Hamaoui, M., Kunis, G., Ophir, E., Landa, G., Cohen, H., & Schwartz, M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604681103 · Cited by 388 · see citing works
Self-citationNeuroprotective role of the innate immune system by microglia
Glezer, I., Simard, A. R., & Rivest, S. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.02.055 · Cited by 371 · see citing works
Ineffective phagocytosis of amyloid-β by macrophages of Alzheimer's disease patients
Fiala, M., Lin, J., Ringman, J. M., Kermani-Arab, V., Tsao, G., Patel, A. J., Lossinsky, A. S., Graves, M. C., Gustavson, A. R., Sayre, J. W., et al. (2005) · Journal of Alzheimer s Disease · doi:10.3233/jad-2005-7304 · Cited by 328 · see citing works
Yamanaka, M., Ishikawa, T., Griep, A., Axt, D., Kummer, M. P., & Heneka, M. T. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.1569-12.2012 · Cited by 326 · cited 3× · see citing works
“…levels of the class A and B scavenger receptors SCARA1 and CD36, respectively, which are known to facilitate phagocytosis of amyloid-b and have been tightly implicated in Alzheimer’s disease patho- physiology (Hickman et al., 2008; Yamanaka et al., 2012; Frenkel et al., 2013; Pey et al., 2014).”
BackgroundMalm, T. M., Koistinaho, M., Pärepalo, M., Vatanen, T., Ooka, A., Karlsson, S., & Koistinaho, J. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.09.009 · Cited by 301 · see citing works
Richard, K. L., Filali, M., Préfontaine, P., & Rivest, S. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.1146-08.2008 · Cited by 261 · see citing works
Real-Time In Vivo Imaging Reveals the Ability of Monocytes to Clear Vascular Amyloid Beta
Michaud, J.-P., Bellavance, M.-A., Préfontaine, P., & Rivest, S. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.10.010 · Cited by 257 · see citing works
Local Neuroinflammation and the Progression of Alzheimer's Disease
McGeer, P. L., & McGeer, E. G. (2002) · Journal of NeuroVirology · doi:10.1080/13550280290100969 · Cited by 255 · see citing works
Bates, K. A., Verdile, G., Li, Q.-X., Ames, D., Hudson, P., Masters, C. L., & Martins, R. N. (2009) · Molecular Psychiatry · doi:10.1038/mp.2008.96 · Cited by 247 · see citing works
Kamphuis, W., Middeldorp, J., Kooijman, L., Sluijs, J. A., Kooi, E., Moeton, M., Freriks, M., Mizee, M. R., & Hol, E. M. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.09.035 · Cited by 244 · see citing works
Cell Mediators of Inflammation in the Alzheimer Disease Brain
Akiyama, H., Arai, T., Kondo, H., Tanno, E., Haga, C., & Ikeda, K. (2000) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-200000001-00008 · Cited by 238 · see citing works
Increased in Vivo Amyloid-β42 Production, Exchange, and Loss in Presenilin Mutation Carriers
Potter, R., Patterson, B. W., Elbert, D. L., Ovod, V., Kasten, T., Sigurdson, W., Mawuenyega, K., Blazey, T., Goate, A., Chott, R., et al. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3005615 · Cited by 236 · see citing works
Boissonneault, V., Filali, M., Lessard, M., Relton, J., Wong, G., & Rivest, S. (2008) · Brain · doi:10.1093/brain/awn331 · Cited by 221 · see citing works
Frenkel, D., Wilkinson, K., Zhao, L., Hickman, S. E., Means, T. K., Puckett, L., Farfara, D., Kingery, N. D., Weiner, H. L., & El Khoury, J. (2013) · Nature Communications · doi:10.1038/ncomms3030 · Cited by 214 · see citing works
Arnon, R., & Aharoni, R. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404887101 · Cited by 205 · see citing works
Frenkel, D., Maron, R., Burt, D. S., & Weiner, H. L. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23241 · Cited by 186 · see citing works
Butovsky, O., Kunis, G., Koronyo‐Hamaoui, M., & Schwartz, M. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05652.x · Cited by 167 · see citing works
Self-citationClearance of Amyloid-β Peptides By Microglia and Macrophages: the Issue of What, When and Where
Lai, A. Y., & McLaurin, J. (2012) · Future Neurology · doi:10.2217/fnl.12.6 · Cited by 161 · see citing works
Frautschy, S. A., Cole, G. M., & Baird, A. (1992) · PubMed Central · Cited by 157 · see citing works
Juedes, A. E., & Ruddle, N. H. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.8.5168 · Cited by 145 · see citing works
Butovsky, O., Koronyo‐Hamaoui, M., Kunis, G., Ophir, E., Landa, G., Cohen, H., & Schwartz, M. (2006) · Cited by 144 · see citing works
Self-citationBales, K. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00143-3 · Cited by 143 · see citing works
Alzheimer’s Disease as Proteolytic Disorders: Anabolism and Catabolism of β-Amyloid
Saido, T. C. (1998) · Neurobiology of Aging · doi:10.1016/s0197-4580(98)00033-5 · Cited by 140 · see citing works
Complement Component C1q Modulates the Phagocytosis of Aβ by Microglia
Webster, S. D., Yang, A. J., Margol, L., Garzon-Rodriguez, W., Glabe, C. G., & Tenner, A. J. (2000) · Experimental Neurology · doi:10.1006/exnr.1999.7260 · Cited by 138 · see citing works
Pey, P., Pearce, R. K., Kalaitzakis, M. E., Griffin, W. S. T., & Gentleman, S. M. (2014) · Acta Neuropathologica Communications · doi:10.1186/2051-5960-2-21 · Cited by 128 · see citing works
Phagocytosis of Amyloid-β and Inflammation: Two Faces of Innate Immunity in Alzheimer's Disease
Fiala, M., Cribbs, D. H., Rosenthal, M. J., & Bernard, G. W. (2007) · Journal of Alzheimer s Disease · doi:10.3233/jad-2007-11406 · Cited by 124 · see citing works
Lebson, L. A., Nash, K. R., Kamath, S. G., Herber, D. L., Carty, N., Lee, D. C., Li, Q., Szekeres, K., Jinwal, U. K., Koren, J., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0329-10.2010 · Cited by 124 · see citing works
Proliferation is a prerequisite for bacterial superantigen-induced T cell apoptosis in vivo.
Renno, T., Hahne, M., & MacDonald, H. R. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.181.6.2283 · Cited by 123 · see citing works
A deficiency in CCR2+ monocytes: the hidden side of Alzheimer’s disease
Naert, G., & Rivest, S. (2013) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjt028 · Cited by 123 · see citing works
Mechanisms of Mononuclear Phagocyte Recruitment in Alzheimers Disease
Hickman, S. E., & Khoury, J. E. (2010) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152710791011982 · Cited by 120 · see citing works
Bernstein, K. E., Koronyo, Y., Salumbides, B. C., Sheyn, J., Pelissier, L., Lopes, D. H. J., Shah, K. H., Bernstein, E. A., Fuchs, D.-T. S., Yu, J. J.-Y., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci66541 · Cited by 117 · see citing works
Self-citationKoronyo‐Hamaoui, M., Ko, M. K., Koronyo, Y., Azoulay, D., Seksenyan, A., Kunis, G., Pham, M. D., Bakhsheshian, J., Rogeri, P. S., Black, K. L., et al. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06402.x · Cited by 113 · see citing works
Self-citationProjections from the brain to the spinal cord in the mouse
Liang, H., Paxinos, G., & WATSON, C. R. R. (2010) · Brain Structure and Function · doi:10.1007/s00429-010-0281-x · Cited by 112 · see citing works
Microglial transplantation increases amyloid‐β clearance in Alzheimer model rats
Takata, K., Kitamura, Y., Yanagisawa, D., Morikawa, S., Morita, M., Inubushi, T., Tsuchiya, D., Chishiro, S., Saeki, M., Taniguchi, T., et al. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.01.009 · Cited by 106 · see citing works
The role and therapeutic potential of monocytic cells in Alzheimer's disease
Malm, T., Koistinaho, M., Muona, A., Magga, J. M., & Koıstınaho, J. (2010) · Glia · doi:10.1002/glia.20973 · Cited by 105 · see citing works
Degradation of fibrillar forms of Alzheimer's amyloid β-peptide by macrophages
Majumdar, A., Chung, H., Dolios, G., Wang, R., Asamoah, N., Lobel, P., & Maxfield, F. R. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.12.001 · Cited by 92 · see citing works
Kato, S., Gondo, T., Hoshii, Y., Takahashi, M., Yamada, M., & Ishihara, T. (1998) · Pathology International · doi:10.1111/j.1440-1827.1998.tb03915.x · Cited by 73 · see citing works
Lampron, A., Pimentel‐Coelho, P. M., & Rivest, S. (2013) · The Journal of Comparative Neurology · doi:10.1002/cne.23363 · Cited by 72 · see citing works
Macrophage-Mediated Degradation of β-Amyloid via an Apolipoprotein E Isoform-Dependent Mechanism
Zhao, L.-Z., Lin, S.-Z., Bales, K., Gelfanova, V., Koger, D., Delong, C., Hale, J., Liu, F., Hunter, J. M., & Paul, S. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5302-08.2009 · Cited by 68 · see citing works
Bakalash, S., Pham, M. D., Koronyo, Y., Salumbides, B. C., Kramerov, A. A., Seidenberg, H., Berel, D., Black, K. L., & Koronyo‐Hamaoui, M. (2011) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.11-7498 · Cited by 44 · see citing works
Self-citationLampron, A., Pimentel‐Coelho, P. M., & Rivest, S. (2013) · The Journal of Comparative Neurology · doi:10.1002/cne.23463 · Cited by 44 · see citing works
Aharoni, R., Sonego, H., Brenner, O. J., Eilam, R., & Arnon, R. (2007) · Immunology Letters · doi:10.1016/j.imlet.2007.07.009 · Cited by 38 · see citing works
Astrocytosis, βA4-protein deposition and paired helical filament formation in Alzheimer's disease
Cairns, N. J., Chadwick, A. J., Luthert, P. J., & Lantos, P. L. (1992) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(92)90134-7 · Cited by 26 · see citing works
Rimoldi, S. F., de Marchi, S. F., Windecker, S., Meier, B., & Allemann, Y. (2010) · Journal of Hypertension · doi:10.1097/hjh.0b013e32833510e5 · Cited by 21 · see citing works
Malm, T., Magga, J. M., & Koıstınaho, J. (2012) · Current Translational Geriatrics and Experimental Gerontology Reports · doi:10.1007/s13670-011-0004-z · Cited by 9 · see citing works
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Keren-Shaul, H., Spinrad, A., Weiner, A., Matcovitch-Natan, O., Dvir-Szternfeld, R., Ulland, T. K., David, E., Baruch, K., Lara-Astaiso, D., Toth, B., et al. (2017) · Cell · doi:10.1016/j.cell.2017.05.018 · Cited by 5,493 · see citing works
Baruch, K., Rosenzweig, N., Kertser, A., Deczkowska, A., Sharif, A. M., Spinrad, A., Tsitsou-Kampeli, A., Sarel, A., Cahalon, L., & Schwartz, M. (2015) · Nature Communications · doi:10.1038/ncomms8967 · Cited by 491 · see citing works
Disease Progression-Dependent Effects of TREM2 Deficiency in a Mouse Model of Alzheimer's Disease
Jay, T. R., Hirsch, A. M., Broihier, M. L., Miller, C. M., Neilson, L. E., Ransohoff, R. M., Lamb, B. T., & Landreth, G. E. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.2110-16.2016 · Cited by 457 · see citing works
Immune cell regulation of glia during CNS injury and disease
Greenhalgh, A. D., David, S., & Bennett, F. C. (2020) · Nature reviews. Neuroscience · doi:10.1038/s41583-020-0263-9 · Cited by 398 · see citing works
Transforming the understanding of brain immunity
Castellani, G., Croese, T., Peralta Ramos, J. M., & Schwartz, M. (2023) · Science · doi:10.1126/science.abo7649 · Cited by 386 · see citing works
Neuroinflammation in Alzheimer’s Disease
Onyango, I. G., Jauregui, G. V., Čarná, M., Bennett, J. P., & Stokin, G. B. (2021) · Biomedicines · doi:10.3390/biomedicines9050524 · Cited by 330 · see citing works
Microglia in Alzheimer’s disease: pathogenesis, mechanisms, and therapeutic potentials
Miao, J., Ma, H., Yang, Y., Liao, Y., Lin, C., Zheng, J., Yu, M., & Lan, J. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1201982 · Cited by 293 · see citing works
Clearance of cerebral Aβ in Alzheimer’s disease: reassessing the role of microglia and monocytes
Zuroff, L. R., Daley, D. A., Black, K. L., & Koronyo‐Hamaoui, M. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2463-7 · Cited by 275 · see citing works
Self-citationNeurological Disease as a Failure of Brain-Immune Crosstalk: The Multiple Faces of Neuroinflammation
Schwartz, M., & Deczkowska, A. (2016) · Trends in Immunology · doi:10.1016/j.it.2016.08.001 · Cited by 246 · see citing works
Targeting Neuroinflammation to Treat Alzheimer’s Disease
Ardura-Fabregat, A., Boddeke, E., Boza‐Serrano, A., Brioschi, S., Castro‐Gomez, S., Ceyzériat, K., Dansokho, C., Dierkes, T., Gelders, G., Heneka, M. T., et al. (2017) · CNS Drugs · doi:10.1007/s40263-017-0483-3 · Cited by 236 · see citing works
Identification of early pericyte loss and vascular amyloidosis in Alzheimer’s disease retina
Shi, H., Koronyo, Y., Rentsendorj, A., Regis, G. C., Sheyn, J., Fuchs, D.-T., Kramerov, A. A., Ljubimov, A. V., Dumitrascu, O. M., Rodriguez, A. R., et al. (2020) · Acta Neuropathologica · doi:10.1007/s00401-020-02134-w · Cited by 230 · see citing works
Self-citationRosenzweig, N., Dvir-Szternfeld, R., Tsitsou-Kampeli, A., Keren‐Shaul, H., Ben-Yehuda, H., Weill-Raynal, P., Cahalon, L., Kertser, A., Baruch, K., Amit, I., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-08352-5 · Cited by 224 · see citing works
β-amyloid, microglia, and the inflammasome in Alzheimer’s disease
Gold, M., & El Khoury, J. (2015) · Seminars in Immunopathology · doi:10.1007/s00281-015-0518-0 · Cited by 187 · see citing works
Exploiting microglial and peripheral immune cell crosstalk to treat Alzheimer’s disease
Dionisio-Santos, D. A., Olschowka, J. A., & O’Banion, M. K. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1453-0 · Cited by 184 · see citing works
Revolution of Alzheimer Precision Neurology. Passageway of Systems Biology and Neurophysiology
Hampel, H. J., (APMI), F. T. A. P. M. I., Toschi, N., Babiloni, C., Baldacci, F., Black, K. L., Bokde, A. L. W., Bun, R. S., Cacciola, F., Cavedo, E., et al. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-179932 · Cited by 181 · see citing works
Self-citationOptical Coherence Tomography in Alzheimer’s Disease and Other Neurodegenerative Diseases
Doustar, J., Torbati, T., Black, K. L., Koronyo, Y., & Koronyo‐Hamaoui, M. (2017) · Frontiers in Neurology · doi:10.3389/fneur.2017.00701 · Cited by 176 · see citing works
Self-citationAntiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances
Jiang, Q., Liu, J., Huang, S., Wang, X.-Y., Chen, X., Liu, G.-H., Ye, K., Song, W., Masters, C. L., Wang, J., et al. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02145-7 · Cited by 165 · see citing works
Retinal pathological features and proteome signatures of Alzheimer’s disease
Koronyo, Y., Rentsendorj, A., Mirzaei, N., Regis, G. C., Sheyn, J., Shi, H., Barrón, E., Cook‐Wiens, G., Rodriguez, A., Medeiros, R., et al. (2023) · Acta Neuropathologica · doi:10.1007/s00401-023-02548-2 · Cited by 155 · see citing works
Self-citationFang, W., Zhai, X., Han, D., Xiong, X., Wang, T., Zeng, X., He, S., Liu, R., Miyata, M., Xu, B., et al. (2018) · Theranostics · doi:10.7150/thno.24475 · Cited by 145 · see citing works
A novel role for osteopontin in macrophage-mediated amyloid-β clearance in Alzheimer’s models
Rentsendorj, A., Sheyn, J., Fuchs, D.-T. S., Daley, D. A., Salumbides, B. C., Schubloom, H. E., Hart, N. J., Li, S., Hayden, E. Y., Teplow, D. B., et al. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.08.019 · Cited by 141 · see citing works
Self-citationThe Emerging Role of Central and Peripheral Immune Systems in Neurodegenerative Diseases
Zang, X., Chen, S., Zhu, J., Ma, J., & Zhai, Y. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.872134 · Cited by 139 · see citing works
Wang, B., Huang, X., Pan, X., Zhang, T., Hou, C., Su, W., Liu, L.-L., Li, J., & Wang, Y. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.06.019 · Cited by 134 · see citing works
Type I/II Interferon Balance in the Regulation of Brain Physiology and Pathology
Deczkowska, A., Baruch, K., & Schwartz, M. (2016) · Trends in Immunology · doi:10.1016/j.it.2016.01.006 · Cited by 125 · see citing works
Alzheimer’s Retinopathy: Seeing Disease in the Eyes
Mirzaei, N., Shi, H., Oviatt, M., Doustar, J., Rentsendorj, A., Fuchs, D.-T. S., Sheyn, J., Black, K. L., Koronyo, Y., & Koronyo‐Hamaoui, M. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00921 · Cited by 130 · see citing works
Self-citationGuedes, J. R., Lao, T., Cardoso, A. L., & El Khoury, J. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00549 · Cited by 115 · see citing works
The role of the immune system in Alzheimer’s disease
Wu, K., Zhang, Y.-R., Huang, Y., Dong, Q., Tan, L., & Yu, J. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101409 · Cited by 116 · see citing works
Wang, B., Lian, Y., Su, W., Wei, P., Dong, X. W., Liu, L.-L., Gong, H., Zhang, T., Jiang, C., & Wang, Y. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.11.017 · Cited by 105 · see citing works
Möhle, L., Israël, N., Paarmann, K., Krohn, M., Pietkiewicz, S., Müller, A. J., Lavrik, I. N., Buguliskis, J. S., Schott, B. H., Schlüter, D., et al. (2016) · Acta Neuropathologica Communications · doi:10.1186/s40478-016-0293-8 · Cited by 101 · see citing works
Alzheimer's disease pathophysiology in the Retina
Gaire, B. P., Koronyo, Y., Fuchs, D.-T. S., Shi, H., Rentsendorj, A., Danziger, R., Vit, J., Mirzaei, N., Doustar, J., Sheyn, J., et al. (2024) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2024.101273 · Cited by 102 · see citing works
Self-citationRetinal Vasculopathy in Alzheimer’s Disease
Shi, H., Koronyo, Y., Rentsendorj, A., Fuchs, D.-T. S., Sheyn, J., Black, K. L., Mirzaei, N., & Koronyo‐Hamaoui, M. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.731614 · Cited by 90 · see citing works
Self-citationAmyloid-beta uptake by blood monocytes is reduced with ageing and Alzheimer’s disease
Chen, S.-H., Tian, D.-Y., Shen, Y.-Y., Cheng, Y., Fan, D.-Y., Sun, H.-L., He, C.-Y., Sun, P.-Y., Bu, X.-L., Zeng, F., et al. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-01113-9 · Cited by 89 · see citing works
CD36 in Alzheimer’s Disease: An Overview of Molecular Mechanisms and Therapeutic Targeting
Dobri, A.-M., Dudău, M., Enciu, A., & Hinescu, M. E. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.11.003 · Cited by 82 · see citing works
Zuo, Z., Qi, F., Yang, J., Wang, X., Wu, Y., Wen, Y., Yuan, Q., Zou, J., Guo, K., & Yao, Z. B. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2017.02.001 · Cited by 79 · see citing works
Ullah, R., Park, T. J., Huang, X., & Kim, M. O. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101451 · Cited by 78 · see citing works
Shapira, R., Solomon, B., Efrati, S., Frenkel, D., & Ashery, U. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.10.007 · Cited by 80 · see citing works
MicroRNA deregulation and chemotaxis and phagocytosis impairment in Alzheimer's disease
Guedes, J. R., Santana, I. J., Cunha, C., Duro, D., Almeida, M. R., Cardoso, A. M., de Lima, M. C. P., & Cardoso, A. L. (2015) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1016/j.dadm.2015.11.004 · Cited by 76 · see citing works
Smit, T., Deshayes, N. A. C., Borchelt, D. R., Kamphuis, W., Middeldorp, J., & Hol, E. M. (2021) · Glia · doi:10.1002/glia.23981 · Cited by 71 · see citing works
Koronyo‐Hamaoui, M., Sheyn, J., Hayden, E. Y., Li, S., Fuchs, D.-T. S., Regis, G. C., Lopes, D. H. J., Black, K. L., Bernstein, K. E., Teplow, D. B., et al. (2019) · Brain · doi:10.1093/brain/awz364 · Cited by 70 · see citing works
Self-citationInnate phagocytosis by peripheral blood monocytes is altered in Alzheimer’s disease
The Australian Imaging, B. A. L. (. S., Gu, B. J., Huang, X., Ou, A., Rembach, A., Fowler, C. J., Avula, P. K., Horton, A., Doecke, J. D., Villemagne, V. L., et al. (2016) · Acta Neuropathologica · doi:10.1007/s00401-016-1596-3 · Cited by 68 · see citing works
Muñoz-Castro, C., Mejias-Ortega, M., Sanchez-Mejias, E., Navarro, V., Trujillo-Estrada, L., Jimenez, S., Garcia-Leon, J. A., Fernandez-Valenzuela, J. J., Sanchez-Mico, M. V., Romero-Molina, C., et al. (2023) · Acta Neuropathologica Communications · doi:10.1186/s40478-023-01530-z · Cited by 66 · see citing works
Neuropathophysiological Mechanisms and Treatment Strategies for Post-traumatic Epilepsy
Sharma, S., Tiarks, G., Haight, J. A., & Bassuk, A. G. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.612073 · Cited by 57 · see citing works
Castellani, G., & Schwartz, M. (2020) · Trends in Immunology · doi:10.1016/j.it.2020.07.005 · Cited by 52 · see citing works
Qi, F., Zuo, Z., Yang, J., Hu, S., Yang, Y., Yuan, Q., Zou, J., Guo, K., & Yao, Z. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0808-7 · Cited by 51 · see citing works
Comparative Review of Microglia and Monocytes in CNS Phagocytosis
Andoh, M., & Koyama, R. (2021) · Cells · doi:10.3390/cells10102555 · Cited by 52 · see citing works
Li, S., Hayden, E. Y., Garcia, V. J., Fuchs, D.-T. S., Sheyn, J., Daley, D. A., Rentsendorj, A., Torbati, T., Black, K. L., Rutishauser, U., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00049 · Cited by 48 · see citing works
Self-citationContributions of monocytes to nervous system disorders
Garré, J. M., & Yang, G. (2018) · Journal of Molecular Medicine · doi:10.1007/s00109-018-1672-3 · Cited by 51 · see citing works
Doustar, J., Rentsendorj, A., Torbati, T., Regis, G. C., Fuchs, D.-T. S., Sheyn, J., Mirzaei, N., Graham, S. L., Shah, P. K., Mastali, M., et al. (2020) · Aging Cell · doi:10.1111/acel.13246 · Cited by 47 · see citing works
Self-citationKey role of the CCR2-CCL2 axis in disease modification in a mouse model of tauopathy
Ben-Yehuda, H., Arad, M., Ramos, J. M. P., Sharon, E., Castellani, G., Ferrera, S., Cahalon, L., Colaiuta, S. P., Salame, T., & Schwartz, M. (2021) · Molecular Neurodegeneration · doi:10.1186/s13024-021-00458-z · Cited by 46 · see citing works
Ullah, R., & Lee, E. J. (2023) · Experimental Neurobiology · doi:10.5607/en23014 · Cited by 49 · see citing works
Jin, N., Gao, L., Fan, X., & Xu, H. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9960-9 · Cited by 46 · see citing works
Kawanishi, S., Takata, K., Itezono, S., Nagayama, H., Konoya, S., Chisaki, Y., Toda, Y., Nakata, S., Yano, Y., Kitamura, Y., et al. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-170994 · Cited by 47 · see citing works
Suzzi, S., Croese, T., Ravid, A., Gold, O., Clark, A. R., Medina, S., Kitsberg, D., Adam, M., Vernon, K. A., Kohnert, E., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-36759-8 · Cited by 47 · see citing works
Dvir-Szternfeld, R., Castellani, G., Arad, M., Cahalon, L., Colaiuta, S. P., Keren‐Shaul, H., Croese, T., Burgaletto, C., Baruch, K., Ulland, T. K., et al. (2021) · Nature Aging · doi:10.1038/s43587-021-00149-w · Cited by 42 · see citing works
Glatiramer Acetate Immunomodulation: Evidence of Neuroprotection and Cognitive Preservation
Kasindi, A., Fuchs, D.-T. S., Koronyo, Y., Rentsendorj, A., Black, K. L., & Koronyo‐Hamaoui, M. (2022) · Cells · doi:10.3390/cells11091578 · Cited by 44 · see citing works
Self-citationImmune-mediated processes in neurodegeneration: where do we stand?
Fakhoury, M. (2016) · Journal of Neurology · doi:10.1007/s00415-016-8052-0 · Cited by 43 · see citing works
PCSK9 ablation attenuates Aβ pathology, neuroinflammation and cognitive dysfunctions in 5XFAD mice
Vilella, A., Bodria, M., Papotti, B., Zanotti, I., Zimetti, F., Remaggi, G., Elviri, L., Potì, F., Ferri, N., Lupo, M. G., et al. (2024) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2023.11.008 · Cited by 43 · see citing works
Gendelman, H. E., & Mosley, R. L. (2015) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-015-9639-4 · Cited by 43 · see citing works
DRGCL: Drug Repositioning via Semantic-Enriched Graph Contrastive Learning
Jia, X., Sun, X., Wang, K., & Li, M. (2024) · IEEE Journal of Biomedical and Health Informatics · doi:10.1109/jbhi.2024.3372527 · Cited by 42 · see citing works
Tajbakhsh, A., Read, M. I., Barreto, G. E., Ávila-Rodriguez, M., Hayat, S. M. G., & Sahebkar, A. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.173873 · Cited by 41 · see citing works
Monocyte-derived macrophages act as reinforcements when microglia fall short in Alzheimer’s disease
Abellanas, M. A., Purnapatre, M., Burgaletto, C., & Schwartz, M. (2025) · Nature Neuroscience · doi:10.1038/s41593-024-01847-5 · Cited by 39 · see citing works
Xing, Z., Zuo, Z., Hu, D., Zheng, X., Wang, X., Yuan, L., Zhou, L., Qi, F., & Yao, Z. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.09.015 · Cited by 38 · see citing works
Lahiri, S., Regis, G. C., Koronyo, Y., Fuchs, D.-T. S., Sheyn, J., Kim, E. H., Mastali, M., Eyk, J. E. V., Rajput, P. S., Lyden, P. D., et al. (2019) · Critical Care · doi:10.1186/s13054-019-2356-2 · Cited by 38 · see citing works
Self-citationHuang, X., Fowler, C. J., Li, Y., Li, Q.-X., Sun, J., Pan, Y., Jin, L., Perez, K. A., Dubois, C., Lim, Y. Y., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-52396-1 · Cited by 37 · see citing works
Wijesinghe, P., Whitmore, C. A., Campbell, M., Li, C. H., Tsuyuki, M., To, E. C., Haynes, J. R., Pham, W. N., & Matsubara, J. A. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1107436 · Cited by 36 · see citing works
Central Nervous System: (Immunological) Ivory Tower or Not?
Marin, I. A., & Kipnis, J. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.122 · Cited by 35 · see citing works
Monocytes in the Peripheral Clearance of Amyloid-β and Alzheimer’s Disease
Guo, H., Zhao, Z., Zhang, R., Chen, P., Zhang, X., Cheng, F., & Gou, X. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-181177 · Cited by 36 · see citing works
Neuroinflammation in Age-Related Neurodegenerative Diseases: Role of Mitochondrial Oxidative Stress
Abadin, X., de Dios, C., Zubillaga, M., Ivars, E., Puigròs, M., Marı́, M., Morales, A., Vizuete, M., Vitórica, J., Trullás, R., et al. (2024) · Antioxidants · doi:10.3390/antiox13121440 · Cited by 35 · see citing works
Schwartz, M., Ramos, J. M. P., & Ben-Yehuda, H. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.1900844 · Cited by 31 · see citing works
PDE inhibition in distinct cell types to reclaim the balance of synaptic plasticity
Rombaut, B., Kessels, S., Schepers, M., Tiane, A., Paes, D., Solomina, Y., Piccart, E., van den Hove, D., Brône, B., Prickaerts, J., et al. (2020) · Theranostics · doi:10.7150/thno.50701 · Cited by 32 · see citing works
Zuroff, L., Torbati, T., Hart, N. J., Fuchs, D., Sheyn, J., Rentsendorj, A., Koronyo, Y., Hayden, E. Y., Teplow, D., Black, K., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01449 · Cited by 32 · see citing works
Self-citationThe retinal pigment epithelium as a gateway for monocyte trafficking into the eye
Benhar, I., Reemst, K., Kalchenko, V., & Schwartz, M. (2016) · The EMBO Journal · doi:10.15252/embj.201694202 · Cited by 31 · see citing works
Repositioning of Immunomodulators: A Ray of Hope for Alzheimer’s Disease?
Munafò, A., Burgaletto, C., Benedetto, G. D., Mauro, M. D., Mauro, R. D., Bernardini, R., & Cantarella, G. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.614643 · Cited by 27 · see citing works
Targeting Impaired Antimicrobial Immunity in the Brain for the Treatment of Alzheimer’s Disease
Fülöp, T., Tripathi, S., Rodrigues, S., Desroches, M., Bunt, T., Eiser, A. R., Bernier, F., Beauregard, P. B., Barron, A. E., Khalil, A., et al. (2021) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s264910 · Cited by 27 · see citing works
Vit, J., Fuchs, D.-T. S., Angel, A., Levy, A., Lamensdorf, I., Black, K. L., Koronyo, Y., & Koronyo‐Hamaoui, M. (2021) · Scientific Reports · doi:10.1038/s41598-021-80988-0 · Cited by 27 · see citing works
Self-citationCellular Mechanisms of Inflammaging and Periodontal Disease
Clark, D. L., Radaic, A., & Kapila, Y. L. (2022) · Frontiers in Dental Medicine · doi:10.3389/fdmed.2022.844865 · Cited by 26 · see citing works
Chen, S., He, C.-Y., Shen, Y., Zeng, G., Tian, D., Cheng, Y., Xu, M., Fan, D., Tan, C., Shi, A., et al. (2021) · Neuroscience Bulletin · doi:10.1007/s12264-021-00779-5 · Cited by 26 · see citing works
Dionisio-Santos, D. A., Karaahmet, B., Belcher, E. K., Owlett, L. D., Trojanczyk, L., Olschowka, J. A., & O’Banion, M. K. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.758677 · Cited by 26 · see citing works
Kuroda, E., Nishimura, K., Kawanishi, S., Sueyoshi, M., Ueno, F., Toji, Y., Abo, N., Konishi, T., Harada, K., Satake, S., et al. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.05.004 · Cited by 24 · see citing works
Potential immunotherapy for Alzheimer disease and age-related dementia
Schwartz, M., Arad, M., & Ben-Yehuda, H. (2019) · Phlebolymphology · doi:10.31887/dcns.2019.21.1/mschwartz · Cited by 24 · see citing works
Effects of immunomodulators on the response induced by vaccines against autoimmune diseases
Marciani, D. J. (2017) · Autoimmunity · doi:10.1080/08916934.2017.1373766 · Cited by 23 · see citing works
Rogers, N. K., Romero, C., SanMartín, C. D., Ponce, D. P., Salech, F., López, M. N., Gleisner, M. A., Tempio, F., & Behrens, M. I. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190839 · Cited by 23 · see citing works
Kang, S., Moser, V. A., Svendsen, C. N., & Goodridge, H. S. (2020) · Communications Biology · doi:10.1038/s42003-020-0797-4 · Cited by 22 · see citing works
Mangin, G., Poittevin, M., Charriaut‐Marlangue, C., Giannesini, C., Merkulova‐Rainon, T., & Kubis, N. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.04.009 · Cited by 22 · see citing works
Regulatory Roles of Bone in Neurodegenerative Diseases
Yu, Z., Ling, Z., Lin, L., Zhao, J. X., Chen, X., Xu, P., & Zou, X. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.610581 · Cited by 22 · see citing works
Luo, D., Li, J., Liu, H., Wang, J., Xia, Y., Qiu, W., Wang, N., Wang, X., Wang, X., Ma, C., et al. (2023) · Advanced Science · doi:10.1002/advs.202300876 · Cited by 21 · see citing works
Chlamydia pneumoniae in Alzheimer's disease pathology
Subedi, L., Gaire, B. P., Koronyo, Y., Koronyo‐Hamaoui, M., & Crother, T. R. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1393293 · Cited by 23 · see citing works
Self-citationZuo, Z., Qi, F., Xing, Z., Yuan, L., Yang, Y., He, Z., Zhou, L., & Yao, Z. (2021) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2021.01.001 · Cited by 19 · see citing works
Al‐Onaizi, M., Thériault, P., Lecordier, S., Préfontaine, P., Rivest, S., & ElAli, A. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.07.016 · Cited by 20 · see citing works
Editorial: Role of Inflammation in Neurodegenerative Diseases
Koronyo‐Hamaoui, M., Gaire, B. P., Frautschy, S. A., & Alvarez, J. I. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.958487 · Cited by 20 · see citing works
Self-citationDisease Progression-Dependent Effects of TREM2 Deficiency in a Mouse Model of Alzheimer's Disease
Jay, T. R., Hirsch, A. M., Broihier, M. L., Miller, C. M., Neilson, L. E., Ransohoff, R. M., Lamb, B. T., & Landreth, G. E. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.2110-16.2017 · Cited by 18 · see citing works
Li, C., Chen, Y.-H., & Zhang, K. (2020) · American Journal of Alzheimer's Disease & Other Dementias® · doi:10.1177/1533317520927169 · Cited by 17 · see citing works
Zhao, J. X., Su, M., Lin, Y., Liu, H., He, Z., & Lai, L. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01781 · Cited by 17 · see citing works
Krix, S., Wilczynski, E., Falgàs, N., Sánchez‐Valle, R., Yoles, E., Nevo, U., Baruch, K., & Fröhlich, H. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1343900 · Cited by 18 · see citing works
Liu, D., Lü, S., Zhang, L., Huang, Y., Ji, M., Sun, X., Liu, X., & Liu, R. (2020) · Vaccines · doi:10.3390/vaccines8030351 · Cited by 16 · see citing works
Chatanaka, M. K., Sohaei, D., Diamandis, E. P., & Prassas, I. (2023) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408363.2023.2187342 · Cited by 15 · see citing works
Rentsendorj, A., Raedschelders, K., Fuchs, D.-T. S., Sheyn, J., Vaibhav, V., Porritt, R. A., Shi, H., Dagvadorj, J., Germano, J. D. F., Koronyo, Y., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1155935 · Cited by 16 · see citing works
Self-citationIsrael, L. L., Braubach, O., Shatalova, E. S., Chepurna, O. M., Sharma, S., Klymyshyn, D., Galstyan, A., Chiechi, A., Cox, A., Herman, D. A., et al. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106307 · Cited by 15 · see citing works
Self-citationMiron, J., Picard, C., Labonté, A., Auld, D. S., & Poirier, J. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-215410 · Cited by 15 · see citing works
Nanomedicine: Pioneering Advances in Neural Disease, Stroke and Spinal Cord Injury Treatment
Loushambam, B., Yanglem, S., Krishnaswami, V., Kumar, M., & Vijayaraghavalu, S. (2025) · Neuroglia · doi:10.3390/neuroglia6010009 · Cited by 14 · see citing works
Danziger, R., Fuchs, D.-T. S., Koronyo, Y., Rentsendorj, A., Sheyn, J., Hayden, E. Y., Teplow, D. B., Black, K. L., Fuchs, S., Bernstein, K. E., et al. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1179315 · Cited by 13 · see citing works
Self-citation
- Authors
- Koronyo, Y., Salumbides, B. C., Sheyn, J., Pelissier, L., Li, S., Ljubimov, V., Moyseyev, M., Daley, D., Fuchs, D.-T., Pham, M., Black, K. L., Rentsendorj, A., & Koronyo-Hamaoui, M.
- Affiliations
- Cedars-Sinai Medical Center (US)
- Venue
- Brain
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-06-06
- Volume
- 138
- Issue
- 8
- Pages
- 2399-2422
- ISSN
- 0006-8950 (ISSN-L)
- 1460-2156
- PMC
- PMC4840949
- OpenAlex
- W2150318471
- Cited by
- 153
- References
- 71
- Citations by year
- 2026: 9 · 2025: 8 · 2024: 16 · 2023: 20 · 2022: 9 · 2021: 25 · 2020: 24 · 2019: 9 · 2018: 7 · 2017: 11 · 2016: 11 · 2015: 4
- FWCI
- 8.11
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Brain (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Health Assistance Foundation
- BrightFocus Foundation
- Alzheimer's Research Trust
- National Institutes of Health (UL1TR000124)
- National Center for Advancing Translational Sciences (Grant UL1TR000124)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- glatiramer acetate, Alzheimer's disease, amyloid plaques, monocyte recruitment, immunotherapy, APPswe/PS1ΔE9 mice, bone marrow-derived myeloid cells, IL-10, MMP-9, macrophage phagocytosis, astrocyte activation, neuroinflammation
- MeSH terms
- Alzheimer Disease, Animals, Brain, Disease Models, Animal, Mice, Transgenic, Monocytes, Receptor, Macrophage Colony-Stimulating Factor, Amyloid beta-Peptides, Amyloid beta-Protein Precursor, Microglia, Plaque, Amyloid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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