The DOI matches its Crossref record; 148 of the 148 references it cites were found in a registry or an index.
CXCR4 and cancer
Abstract
The chemokine receptor CXCR4 belongs to the large superfamily of G protein-coupled receptors and has been identified to play a crucial role in a number of biological processes, including the trafficking and homeostasis of immune cells such as T lymphocytes. CXCR4 has also been found to be a prognostic marker in various types of cancer, including leukemia and breast cancer, and recent evidence has highlighted the role of CXCR4 in prostate cancer. Furthermore, CXCR4 expression is upregulated in cancer metastasis, leading to enhanced signaling. These observations suggest that CXCR4 is important for the progression of cancer. The CXCR4-CXCL12 (stromal cell-derived factor 1 (SDF-1)) axis has additionally been identified to have a role in normal stem cell homing. Interestingly, cancer stem cells also express CXCR4, indicating that the CXCR4-SDF-1 axis may direct the trafficking and metastasis of these cells to organs that express high levels of SDF-1, such as the lymph nodes, lungs, liver, and bone. This review focuses on the current knowledge of CXCR4 regulation and how deregulation of this protein may contribute to the progression of cancer.
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1 retracted
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RetractedStem cells, cancer, and cancer stem cells
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International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels
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The fundamental role of epigenetic events in cancer
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Involvement of chemokine receptors in breast cancer metastasis
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HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled Receptor
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Cited by
The role of CXCR4 in multiple myeloma: Cells’ journey from bone marrow to beyond
Ullah, T. R. (2019) · Journal of Bone Oncology · doi:10.1016/j.jbo.2019.100253 · Cited by 141
Metadata
- Authors
- Furusato, B., Mohamed, A., Uhlén, M., & Rhim, J. S.
- Venue
- Pathology International
- Publisher
- Wiley
- Published
- 2010-06-08
- Volume
- 60
- Issue
- 7
- Pages
- 497-505
- ISSN
- 1320-5463 (ISSN-L)
- 1440-1827
- OpenAlex
- W1867767808
- Cited by
- 290
- References
- 148
- FWCI
- 11.25
- Type
- journal article
- Language
- en
- Open access
- closed
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- Furusato, B., Mohamed, A., Uhlén, M., & Rhim, J. S. (2010). CXCR4 and cancer. Pathology International. https://doi.org/10.1111/j.1440-1827.2010.02548.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
