New reference growth charts for Japanese girls with Turner syndrome
Abstract
BACKGROUND: Currently used growth charts for Japanese girls with Turner syndrome (TS) were constructed with auxological data obtained before the secular trend in growth reached a plateau. These charts were published in 1992 and may no longer be valid for the evaluation of stature and growth in girls with TS in clinical settings. Thus, we need to establish new clinical growth charts. METHODS: The samples for analysis were obtained by a retrospective cohort study. A total of 1867 Japanese girls with TS were registered between 1991 and 2004 for growth hormone (GH) treatment and their pretreatment anthropometric measurements were obtained. Reference growth charts were newly constructed using the LMS method from 1447 girls' cross-sectional data after exclusion of measurements derived from those with the presence of puberty, with previous growth-promoting treatment, or without cytogenetic evidence of TS. RESULTS: The new clinical reference growth charts differ from the old charts. Secular trends can be detected in both height and weight. Mean adult height on the new chart is 141.2 cm, 3.0 cm taller than the old data. This result seems attributable to the secular trend observed during the same period in Japanese women. CONCLUSIONS: The newly constructed clinical reference growth charts for Japanese girls with TS seem to be better for the evaluation of growth in girls with TS born after approximately 1970, although selection bias and some other limitations in the present study should be kept in mind.
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Average adult height in TS ranges from 138 to 147 cm depending on the country, a deficit of ~20 cm (-3 SD) compared with population means.
“resulting in an average adult height ranging from 138 to 147 cm, depending on the country; this represents a deficit of ∼20 cm (−3 SD) compared with population means for many countries.139,142,143”
From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [139]
Average birth weight is ~300-1000 grams below mean and length 1-2 cm below mean for healthy infants of similar gestational age and country of birth.
“resulting in average birth weight ∼300-1000 grams and length 1-2 cm below mean values for healthy infants of similar gestational age and country of birth.59,138,139”
From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [139]
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Clinical practice guidelines for the care of girls and women with Turner syndrome.
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Nishigaki, S., Itonaga, T., Hasegawa, Y., & Kawai, M. (2021) · Clinical Endocrinology · doi:10.1111/cen.14484 · Cited by 19 · see citing works
- Authors
- Isojima, T., Yokoya, S., Ito, J., Horikawa, R., & Tanaka, T.
- Affiliations
- National Center For Child Health and Development (JP)
- Foundation for Growth Science (JP)
- Corresponding author
- Isojima, Tsuyoshi
- Venue
- Pediatrics International
- Publisher
- Wiley
- Published
- 2009-09-28
- Volume
- 51
- Issue
- 5
- Pages
- 709-714
- ISSN
- 1328-8067 (ISSN-L)
- 1442-200X
- OpenAlex
- W2000145329
- Cited by
- 29
- References
- 21
- Citations by year
- 2026: 1 · 2024: 3 · 2023: 1 · 2021: 11 · 2020: 1 · 2019: 2 · 2017: 2 · 2016: 1 · 2015: 3 · 2014: 2
- FWCI
- 0.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pediatrics International (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Human Health and Disease
- Keywords
- Turner syndrome, reference growth charts, Japanese girls, secular growth trends, adult height prediction, LMS algorithm, growth hormone therapy, anthropometry
- MeSH terms
- Adolescent, Child, Child, Preschool, Cross-Sectional Studies, Female, Humans, Infant, Infant, Newborn, Japan, Reference Values, Retrospective Studies, Turner Syndrome, Reproducibility of Results, Cohort Studies, Young Adult, Growth Charts
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