The DOI matches its Crossref record; 98 of the 98 references it cites were found in a registry or an index.
Role of antioxidants in the treatment of male infertility
Open accessAbstract
Male infertility continues to be a clinical challenge of increasing significance. While male factors such as decreased semen quality are responsible for 25% of all infertility issues, the etiology of suboptimal semen quality is poorly understood. Many physiological, environmental, and genetic factors have been implicated, including oxidative stress. Oxidative stress is induced by reactive oxygen species (ROS), or free radicals, and although ROS are required for critical aspects of sperm function, excessive levels of ROS can negatively impact sperm quality. The origin of ROS generation, and the etiologies of increased ROS in men with suboptimal sperm quality have only recently been elucidated, offering multiple targets for potential therapy. Here, we present a critical review of the literature describing the role of oxidative stress on decreased sperm function, as well as the role of antioxidants in the treatment of male factor infertility.
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“According to Salas-Huetos et al., oxidative stress can be reduced by the antioxidant properties of fruits and vegetables, since these antioxidants act as scavengers and reduce reactive oxygen species [89,90].”
From Mediterranean Diet as an Antioxidant: The Impact on Metabolic Health and Overall Wellbeing (2021) · cites this paper as [89]
Citations
Cites
Oxidative stress and male infertility—a clinical perspective
Tremellen, K. P. (2008) · Human Reproduction Update · doi:10.1093/humupd/dmn004 · Cited by 1,544
REVIEW ARTICLE: Clinical Relevance of Oxidative Stress in Male Factor Infertility: An Update
Agarwal, A., Makker, K., & Sharma, R. (2007) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.2007.00559.x · Cited by 832
Self-citationBest practice policies for male infertility
Sharlip, I. D., Jarow, J. P., Belker, A. M., Lipshultz, L. I., Sigman, M., Thomas, A. J., Jr., Schlegel, P. N., Howards, S. S., Nehra, A. X., Damewood, M. D., et al. (2002) · Fertility and Sterility · doi:10.1016/s0015-0282(02)03105-9 · Cited by 774
Oxidative Stress and Male Infertility: From Research Bench to Clinical Practice
Saleh, R. A., & HCLD, A. A. (2002) · Journal of Andrology · doi:10.1002/j.1939-4640.2002.tb02324.x · Cited by 711
Free radicals, lipid peroxidation and sperm function
Aitken, R. J. (1995) · Reproduction Fertility and Development · doi:10.1071/rd9950659 · Cited by 674
Lipid Peroxidation and Human Sperm Motility: Protective Role of Vitamin E
SULEIMAN, S. A., Ali, M., Zaki, Z. M. S., Elmalik, E. M. A., & NASR, M. A. (1996) · Journal of Andrology · doi:10.1002/j.1939-4640.1996.tb01830.x · Cited by 662
Antioxidant nutrients and lead toxicity
Hsu, P. (2002) · Toxicology · doi:10.1016/s0300-483x(02)00380-3 · Cited by 599
Reactive oxygen species generation and human spermatozoa: The balance of benefit and risk
Aitken, R. J., & Fisher, H. M. (1994) · BioEssays · doi:10.1002/bies.950160409 · Cited by 584
Increased oxidative deoxyribonucleic acid damage in the spermatozoa of infertile male patients
Kodama, H., Yamaguchi, R., Fukuda, J., Kasai, H., & Tanaka, T. (1997) · Fertility and Sterility · doi:10.1016/s0015-0282(97)00236-7 · Cited by 528
Reduction of the Incidence of Sperm DNA Fragmentation by Oral Antioxidant Treatment
Greco, E., Iacobelli, M., Rienzi, L. F., Ubaldi, F. M., Ferrero, S., & Tesařík, J. (2005) · Journal of Andrology · doi:10.2164/jandrol.04146 · Cited by 511
Cited by
Sorted by citations
Effect of Oxidative Stress on Male Reproduction
Agarwal, A. K., Virk, G., Ong, C. S. H., & du Plessis, S. S. (2014) · The World Journal of Men s Health · doi:10.5534/wjmh.2014.32.1.1 · Cited by 1,335
Self-citationLifestyle factors and reproductive health: taking control of your fertility
Sharma, R. K., Biedenharn, K. R., Fedor, J., & Agarwal, A. K. (2013) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-11-66 · Cited by 868
Self-citationImpacts of Oxidative Stress and Antioxidants on Semen Functions
Bansal, A. K., & Bilaspuri, G. S. (2010) · Veterinary Medicine International · doi:10.4061/2011/686137 · Cited by 802
The effect of sperm DNA fragmentation on miscarriage rates: a systematic review and meta-analysis
Robinson, L., Gallos, I. D., Conner, S. J., Rajkhowa, M., Miller, D., Lewis, S., Kirkman-Brown, J., & Coomarasamy, A. (2012) · Human Reproduction · doi:10.1093/humrep/des261 · Cited by 629
Barati, E., Nikzad, H., & Karimian, M. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03253-8 · Cited by 589
Metadata
- Authors
- Kefer, J. C., Agarwal, A., & Sabanegh, E.
- Affiliations
- Cleveland Clinic (US)
- Corresponding author
- Agarwal, Ashok
- ORCID
- Agarwal, Ashok
- Venue
- International Journal of Urology
- Publisher
- Wiley
- Published
- 2009-04-28
- Volume
- 16
- Issue
- 5
- Pages
- 449-457
- ISSN
- 0919-8172 (ISSN-L)
- 1442-2042
- OpenAlex
- W2166623820
- Cited by
- 273
- References
- 97
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 10 · 2023: 20 · 2022: 16 · 2021: 14 · 2020: 21 · 2019: 17 · 2018: 17 · 2017: 15 · 2016: 16 · 2015: 16 · 2014: 23 · 2013: 19 · 2012: 19
- FWCI
- 2.54
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- International Journal of Urology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
- Keywords
- male infertility, antioxidants, oxidative stress, reactive oxygen species, semen quality, male factor infertility, antioxidant therapy, sperm function
- MeSH terms
- Antioxidants, Humans, Infertility, Male, Male, Spermatozoa, Oxidants, Oxidative Stress
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