Cited by 274Sperm and Testicular FunctionAntioxidant Activity and Oxidative StressReproductive Biology and Fertility

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Role of antioxidants in the treatment of male infertility

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Kefer, John C, Agarwal, Ashok, Sabanegh, Edmund·2009·International Journal of Urology

DOI 10.1111/j.1442-2042.2009.02280.x

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Abstract

Male infertility continues to be a clinical challenge of increasing significance. While male factors such as decreased semen quality are responsible for 25% of all infertility issues, the etiology of suboptimal semen quality is poorly understood. Many physiological, environmental, and genetic factors have been implicated, including oxidative stress. Oxidative stress is induced by reactive oxygen species (ROS), or free radicals, and although ROS are required for critical aspects of sperm function, excessive levels of ROS can negatively impact sperm quality. The origin of ROS generation, and the etiologies of increased ROS in men with suboptimal sperm quality have only recently been elucidated, offering multiple targets for potential therapy. Here, we present a critical review of the literature describing the role of oxidative stress on decreased sperm function, as well as the role of antioxidants in the treatment of male factor infertility.

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Agarwal A, 2007, Clinical relevance of oxidative stress in patients with male factor infertility: Evidence‐based analysis, AUA Update Ser., 26, 1
10.1111/j.1365-2605.1996.tb00523.x · DOI
10.1093/humupd/dmn004 · DOI

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See all 274

Authors: Kefer, J. C., Agarwal, A., & Sabanegh, E.
Affiliations: Cleveland Clinic (US)
Corresponding author: Agarwal, Ashok
ORCID: Agarwal, Ashok
Venue: International Journal of Urology
Publisher: Wiley
Published: 2009-04-28
Volume: 16
Issue: 5
Pages: 449-457
ISSN: 0919-8172 (ISSN-L)
1442-2042
DOI: 10.1111/j.1442-2042.2009.02280.x
OpenAlex: W2166623820
Cited by: 273
References: 97
Citations by year: 2026: 4 · 2025: 10 · 2024: 10 · 2023: 20 · 2022: 16 · 2021: 14 · 2020: 21 · 2019: 17 · 2018: 17 · 2017: 15 · 2016: 16 · 2015: 16 · 2014: 23 · 2013: 19 · 2012: 19
FWCI: 2.54
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: International Journal of Urology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
Keywords: male infertility, antioxidants, oxidative stress, reactive oxygen species, semen quality, male factor infertility, antioxidant therapy, sperm function
MeSH terms: Antioxidants, Humans, Infertility, Male, Male, Spermatozoa, Oxidants, Oxidative Stress

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Role of antioxidants in the treatment of male infertility

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