The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Learning deficit in BDNF mutant mice.
Abstract
Brain-derived neurotrophic factor (BDNF) has been implicated in the regulation of high-frequency synaptic transmission and long-term potentiation in the hippocampus, processes that are also thought to be involved in the learning of spatial tasks such as the Morris water maze. In order to determine whether BDNF is required for normal spatial learning, mice carrying a deletion in one copy of the BDNF gene were subjected to the Morris water maze task. Young adult BDNF mutant mice were significantly impaired compared with wild-type mice, requiring twice the number of days to reach full performance. Aged wild-type mice performed significantly worse than young wild-type mice and the effect was even more pronounced in the BDNF mutant mice, which did not learn at all. Although there was no difference in mean swimming speed between BDNF mutant and wild-type mice, we cannot exclude the possibility that developmental or peripheral deficits also contribute to the learning deficits in these mice. In situ hybridization and RNase protection analysis revealed that BDNF mRNA expression was indeed decreased in BDNF mutant mice. Furthermore, a pronounced effect of age on BDNF mRNA expression was seen, displayed as both a reduced level of mRNA expression and a reduced or entirely absent layer-specific expression pattern in the cerebral cortex of aged animals. Thus, our data suggest that BDNF expression may be linked to learning.
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“The importance of BDNF to hippocampal neuroplasticity is epitomized by animal studies, which have found that the manipulation of BDNF expression directly impacts upon performance in spatial and contextual memory tasks (Linnarsson et al., 1997; Alonso et al., 2002; Heldt et al., 2007; Peters et al., 2010), and also that the downregulation of BDNF inhibits AE induced improvements in spatial memory”
From Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment (2016) · cites this paper as Linnarsson et al., 1997
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da Luz, A. C. D. D. S., Dias, G. P., Bevilaqua, M. C. D. N., Cocks, G. D., Gardino, P. F., Thuret, S., & Nardi, A. E. (2013) · Neuropsychobiology · doi:10.1159/000353269 · Cited by 4,015
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Metadata
- Authors
- Linnarsson, S., Björklund, A., & Ernfors, P.
- Affiliations
- Karolinska Institutet (SE)
- Lund University (SE)
- Corresponding author
- Linnarsson, Sten
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 1997-12
- Volume
- 9
- Issue
- 12
- Pages
- 2581-2587
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- OpenAlex
- W2136761139
- Cited by
- 471
- References
- 44
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 7 · 2023: 12 · 2022: 10 · 2021: 9 · 2020: 11 · 2019: 12 · 2018: 9 · 2017: 16 · 2016: 20 · 2015: 25 · 2014: 25 · 2013: 29 · 2012: 30
- FWCI
- 3.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Cancerfonden
- Vetenskapsrådet
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- brain-derived neurotrophic factor, BDNF knockout mice, spatial learning, Morris water maze, hippocampus, long-term potentiation, synaptic transmission, BDNF mRNA expression, age-related decline, cerebral cortex, learning deficits
- MeSH terms
- Age Factors, Animals, Mice, Inbred BALB C, Mice, Neurologic Mutants, Retention, Psychology, RNA, Messenger, Spatial Behavior, Long-Term Potentiation, Gene Expression Regulation, Developmental, Maze Learning, Brain-Derived Neurotrophic Factor, Mice
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