Cited by 337Pain Mechanisms and TreatmentsPain Management and Placebo EffectPain Management and Treatment

The DOI matches its Crossref record; 90 of the 90 references it cites were found in a registry or an index.

Attention to pain localization and unpleasantness discriminates the functions of the medial and lateral pain systems.

Kulkarni, B., Bentley, D. E., Elliott, R., Youell, P., Watson, A., Derbyshire, S. W. G., Frackowiak, R. S. J., Friston, K. J., Jones, A. K. P.·2005·European Journal of Neuroscience

DOI 10.1111/j.1460-9568.2005.04098.x

Open this paper in CoChat — free account

Abstract

Functional imaging studies have identified a matrix of structures in the brain that respond to noxious stimuli. Within this matrix, a division of function between sensory-discriminative and affective responses has so far been demonstrated by manipulating either pain intensity or unpleasantness under hypnosis in two different normal volunteer groups studied on separate occasions. Our study used positron emission tomography (PET) to demonstrate this division of function under more natural conditions in a healthy group of volunteers, using a CO(2) laser to provide nociceptive stimuli that selectively activate A-delta and C-fibres without contamination by touch sensations. We measured the differential cerebral responses to noxious and innocuous laser stimuli during conditions of selective attention to either the unpleasantness or location of the stimuli. Attention to location increased responses in the contralateral (right) primary somatosensory and inferior parietal cortices. This result implies that these components of the lateral pain system are concerned mainly with the localization of pain. In contrast, attention to unpleasantness increased responses in bilateral perigenual cingulate and orbitofrontal cortices, contralateral (right) amygdala, ipsilateral (left) hypothalamus, posterior insula, M1 and frontal pole. These areas comprise key components of the medial pain and neuroendocrine systems and the results suggest that they have a role in the affective response to pain. Our results indicate the importance of attentional effects on the pattern of nociceptive processing in the brain. They also provide the first clear demonstration, within a single experiment, of a major division of function within the neural pain matrix.

Integrity signals

Registry

Crossref · 10.1111/j.1460-9568.2005.04098.x

Cites

90 of 90 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Statistical parametric maps in functional imaging: A general linear approach
Friston, K. J., Holmes, A. P., Worsley, K. J., Poline, J. ‐., Frith, C. D., & Frackowiak, R. S. J. (1994) · Human Brain Mapping · doi:10.1002/hbm.460020402 · Cited by 9,688
Self-citation
The attention system of the human brain
Posner, M. I., & Petersen, S. E. (1990) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.13.030190.000325 · Cited by 8,070 · cited 1×
“The MCC is also an important component of the anterior attentional system (Posner & Petersen, 1990; Bush et al., 2000), although nociceptive responses appear to locate to discrete areas that are distinct from those concerned with these more general attentional functions (Derbyshire et al., 1998).”
Background
Cognitive and emotional influences in anterior cingulate cortex
Bush, G., Luu, P., & Posner, M. I. (2000) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(00)01483-2 · Cited by 6,259
Empathy for Pain Involves the Affective but not Sensory Components of Pain
Singer, T., Seymour, B., O'Doherty, J., Kaube, H., Dolan, R. J., & Frith, C. D. (2004) · Science · doi:10.1126/science.1093535 · Cited by 3,929
Contributions of anterior cingulate cortex to behaviour
Devinsky, O., Morrell, M. J., & Vogt, B. A. (1995) · Brain · doi:10.1093/brain/118.1.279 · Cited by 3,377
Large-scale neurocognitive networks and distributed processing for attention, language, and memory
Mesulam, M. (1990) · Annals of Neurology · doi:10.1002/ana.410280502 · Cited by 2,684
Pain Affect Encoded in Human Anterior Cingulate But Not Somatosensory Cortex
Rainville, P., Duncan, G. H., Price, D. D., Carrier, B., & Bushnell, M. C. (1997) · Science · doi:10.1126/science.277.5328.968 · Cited by 2,629
Functional imaging of brain responses to pain. A review and meta-analysis (2000)
Peyron, R., Laurent, B., & García-Larrea, L. (2000) · Neurophysiologie Clinique/Clinical Neurophysiology · doi:10.1016/s0987-7053(00)00227-6 · Cited by 2,171
Placebo and Opioid Analgesia-- Imaging a Shared Neuronal Network
Petrovic, P., Kalso, E., Petersson, K. M., & Ingvar, M. (2002) · Science · doi:10.1126/science.1067176 · Cited by 1,488
Human Experimentation: Code of Ethics of W.M.A
RICKHAM, P. P. (1964) · BMJ · doi:10.1136/bmj.2.5402.177 · Cited by 1,457

Show all 90 references

Research works printed but not linked: 2

Melzack R., 1968, The Skin Senses., 423
Rolls E.T., 1999, The Brain and Emotion, 75

Sorted by citations

Items 101–200 of 337

Non-invasive vagal nerve stimulation decreases brain activity during trauma scripts
Wittbrodt, M. T., Gurel, N. Z., Nye, J. A., Ladd, S. L., Shandhi, M. M. H., Huang, M., Shah, A. J., Pearce, B. D., Alam, Z. S., Rapaport, M. H., et al. (2020) · Brain stimulation · doi:10.1016/j.brs.2020.07.002 · Cited by 56
Dissociating nociceptive modulation by the duration of pain anticipation from unpredictability in the timing of pain
Clark, J. A., Brown, C. A., Jones, A. K. P., & El‐Deredy, W. (2008) · Clinical Neurophysiology · doi:10.1016/j.clinph.2008.09.022 · Cited by 57
Self-citation
Acupuncture – Self-Appraisal and the Reward System
Lundeberg, T., Lund, I., & Näslund, J. (2007) · Acupuncture in Medicine · doi:10.1136/aim.25.3.87 · Cited by 53
Pain: A Distributed Brain Information Network?
Mano, H., & Seymour, B. (2015) · PLoS Biology · doi:10.1371/journal.pbio.1002037 · Cited by 66
A Parabrachial-to-Amygdala Circuit That Determines Hemispheric Lateralization of Somatosensory Processing
Allen, H. N., Chaudhry, S., Hong, V. M., Lewter, L. A., Sinha, G. P., Carrasquillo, Y., Taylor, B. K., & Kolber, B. J. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2022.09.010 · Cited by 51
Imaging signatures of altered brain responses in small-fiber neuropathy
Hsieh, P.-C., Tseng, M., Chao, C., Lin, Y.-H., Tseng, W. I., Liu, K.-H., Chiang, M., & Hsieh, S. (2015) · Pain · doi:10.1097/j.pain.0000000000000128 · Cited by 52
5-HT modulation of pain perception in humans
Martin, S. L., Power, A., Boyle, Y., Anderson, I. M., Silverdale, M., & Jones, A. K. P. (2017) · Psychopharmacology · doi:10.1007/s00213-017-4686-6 · Cited by 53
Self-citation
Burst Spinal Cord Stimulation: Review of Preclinical Studies and Comments on Clinical Outcomes
Chakravarthy, K. V., Kent, A. R., Raza, A., Fang, X., & Kinfe, T. M. (2018) · Neuromodulation Technology at the Neural Interface · doi:10.1111/ner.12756 · Cited by 51
Ranking brain areas encoding the perceived level of pain from fMRI data
Favilla, S., Huber, A., Pagnoni, G., Lui, F., Facchin, P., Cocchi, M., Baraldi, P., & Porro, C. A. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.01.001 · Cited by 51
Taking Sides with Pain – Lateralization aspects Related to Cerebral Processing of Dental Pain
Brügger, M., Ettlin, D. A., Meier, M. L., Keller, T., Luechinger, R., Barlow, A. P. S., Palla, S., Jäncke, L., & Lutz, K. (2011) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2011.00012 · Cited by 51
Differential effects of cathodal transcranial direct current stimulation of prefrontal, motor and somatosensory cortices on cortical excitability and pain perception – a double‐blind randomised sham‐controlled study
Vaseghi, B., Zoghi, M., & Jaberzadeh, S. (2015) · European Journal of Neuroscience · doi:10.1111/ejn.13043 · Cited by 53
A Meta-Analysis of Site-Specific Effects of Cathodal Transcranial Direct Current Stimulation on Sensory Perception and Pain
Vaseghi, B., Zoghi, M., & Jaberzadeh, S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0123873 · Cited by 53
A comparison between the neural correlates of laser and electric pain stimulation and their modulation by expectation
Hird, E., Jones, A. K. P., Talmi, D., & El‐Deredy, W. (2017) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2017.09.011 · Cited by 48
Self-citation
Parietal cortex involvement in the localization of tactile and noxious mechanical stimuli: a transcranial magnetic stimulation study.
Porro, C., Martinig, M., Facchin, P., Maieron, M., Jones, A. K. P., & Fadiga, L. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.11.011 · Cited by 64
Self-citation
Prefrontal contributions to the stability and variability of thought and conscious experience
Zamani, A., Carhart-Harris, R. L., & Kalina Christoff, A. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01147-7 · Cited by 49
Neural activity related to self‐ versus externally generated painful stimuli reveals distinct differences in the lateral pain system in a parametric fMRI study
Helmchen, C., Mohr, C. H., Erdmann, C., Binkofski, F., & Büchel, C. (2006) · Human Brain Mapping · doi:10.1002/hbm.20217 · Cited by 48
Asymmetry of the Endogenous Opioid System in the Human Anterior Cingulate: a Putative Molecular Basis for Lateralization of Emotions and Pain
Watanabe, H., Fitting, S., Hussain, M. Z., Kononenko, O., Iatsyshyna, A. P., Yoshitake, T., Kehr, J., Alkass, K., Druid, H., Wadensten, H., et al. (2013) · Cerebral Cortex · doi:10.1093/cercor/bht204 · Cited by 45
The Contribution of Endogenous Modulatory Systems to TMS- and tDCS-Induced Analgesia: Evidence from PET Studies
DosSantos, M. F. H., Oliveira, A. T., Ferreira, N. R., Carvalho, A. C. P., & Rosado-de-Castro, P. H. (2018) · Pain Research and Management · doi:10.1155/2018/2368386 · Cited by 44
A nigro–subthalamo–parabrachial pathway modulates pain-like behaviors
Jia, T., Wang, Y.-D., Chen, J., Zhang, X., Cao, J., Xiao, C., & Zhou, C. (2022) · Nature Communications · doi:10.1038/s41467-022-35474-0 · Cited by 47
Persistent antinociception through repeated self-injury in patients with borderline personality disorder
Magerl, W., Burkart, D., Fernandez, A., Schmidt, L., & Treede, R. (2011) · Pain · doi:10.1016/j.pain.2011.11.021 · Cited by 48
Acute calming effects of alcohol are associated with disruption of the salience network
Gorka, S. M., Phan, K. L., & Childs, E. (2017) · Addiction Biology · doi:10.1111/adb.12537 · Cited by 44
Categories of placebo response in the absence of site-specific expectation of analgesia
Watson, A., El‐Deredy, W., Bentley, D. E., Vogt, B. A., & Jones, A. K. P. (2006) · Pain · doi:10.1016/j.pain.2006.06.021 · Cited by 44
Self-citation
Rubber Hand Illusion Reduces Discomfort Caused by Cold Stimulus
Siedlecka, M., Klimza, A., Łukowska, M., & Wierzchoń, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0109909 · Cited by 42
The cingulate cortex in neurologic diseases: History, Structure, Overview
Vogt, B. A. (2019) · Handbook of clinical neurology · doi:10.1016/b978-0-444-64196-0.00001-7 · Cited by 46
The effect of transcranial direct stimulation as an add-on treatment to conventional physical therapy on pain intensity and functional ability in individuals with knee osteoarthritis: A randomized controlled trial
Rahimi, F. C., Nejati, V., Nassadj, G., Ziaei, B., & Mohammadi, H. (2021) · Neurophysiologie Clinique · doi:10.1016/j.neucli.2021.06.002 · Cited by 42
Altered cerebral blood flow in the anterior cingulate cortex is associated with neuropathic pain
Watanabe, K., Hirano, S., Kojima, K., Nagashima, K., Mukai, H., Sato, T., Takemoto, M., Matsumoto, K., Iimori, T., Isose, S., et al. (2018) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2017-316601 · Cited by 43
Primary and secondary somatosensory cortex responses to anticipation and pain: a magnetoencephalography study
Worthen, S. F., Hobson, A. R., Hall, S. D., Aziz, Q., & Furlong, P. L. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07575.x · Cited by 40
Testosterone effects on pain and brain activation patterns
Choi, J. C., Park, Y. ‐., Park, S. K., Lee, J. S., Kim, J., Choi, J. I., Yoon, K. B., Lee, S., Lim, D. E., Choi, J.-H., et al. (2017) · Acta Anaesthesiologica Scandinavica · doi:10.1111/aas.12908 · Cited by 44
Assessment of brain mechanisms involved in the processes of thermal sensation, pleasantness/unpleasantness, and evaluation
Aizawa, Y., Harada, T., Nakata, H., Tsunakawa, M., Sadato, N., & Nagashima, K. (2019) · IBRO Reports · doi:10.1016/j.ibror.2019.01.003 · Cited by 43
Brain activation upon selective stimulation of cutaneous C- and Aδ-fibers
Weiß, T., Straube, T., Boettcher, J., Hecht, H., Spohn, D., & Miltner, W. H. R. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.03.047 · Cited by 40
Long‐term depression of pain‐related cerebral activation in healthy man: An fMRI study
Rottmann, S., Jung, K., Vohn, R., & Ellrich, J. (2009) · European Journal of Pain · doi:10.1016/j.ejpain.2009.10.006 · Cited by 40
Correlation of human cold pressor pain responses with 5-HT1A receptor binding in the brain
Martikainen, I. K., Hirvonen, J., Kajander, J., Hagelberg, N. M., Mansikka, H. T., Någren, K., Hietala, J. A., & Pertovaara, A. (2007) · Brain Research · doi:10.1016/j.brainres.2007.07.036 · Cited by 40
Replacing animal experiments: choices, chances and challenges
Langley, G., Evans, T. J., Holgate, S. T., & Jones, A. K. P. (2007) · BioEssays · doi:10.1002/bies.20628 · Cited by 37
Self-citation
Polarity-specific modulation of pain processing by transcranial direct current stimulation – a blinded longitudinal fMRI study
Naegel, S., Biermann, J., Theysohn, N., Kleinschnitz, C., Diener, H., Katsarava, Z., Obermann, M., & Holle, D. (2018) · The Journal of Headache and Pain · doi:10.1186/s10194-018-0924-5 · Cited by 42
Active Recharge Burst and Tonic Spinal Cord Stimulation Engage Different Supraspinal Mechanisms: A Functional Magnetic Resonance Imaging Study in Peripherally Injured Chronic Neuropathic Rats
Meuwissen, K. P. V., van der Toorn, A., Gu, J. W., Zhang, T. C., Dijkhuizen, R. M., & Joosten, E. A. J. (2020) · Pain Practice · doi:10.1111/papr.12879 · Cited by 37
Longitudinal changes in functional connectivity and pain-induced brain activations in patients with migraine: a functional MRI study pre- and post- treatment with Erenumab
Schwedt, T. J., Nikolova, S., Dumkrieger, G. M., Li, J., Wu, T., & Chong, C. D. (2022) · The Journal of Headache and Pain · doi:10.1186/s10194-022-01526-5 · Cited by 35
Role of Functional Brain Imaging in Understanding Rheumatic Pain
Jones, A. K. P., Huneke, N. T. M., Lloyd, D. M., Brown, C. A., & Watson, A. (2012) · Current Rheumatology Reports · doi:10.1007/s11926-012-0287-x · Cited by 34
Self-citation
Opioid modulation of resting-state anterior cingulate cortex functional connectivity
Gorka, S. M., Fitzgerald, D. A., de Wit, H., Angstadt, M., & Phan, K. L. (2014) · Journal of Psychopharmacology · doi:10.1177/0269881114548436 · Cited by 34
Selective modulation of nociceptive processing due to noise distraction
Boyle, Y., El‐Deredy, W., Montes, E. M., Bentley, D. E., & Jones, A. K. P. (2008) · Pain · doi:10.1016/j.pain.2008.02.020 · Cited by 32
Self-citation
Chronic constriction injury reduces cannabinoid receptor 1 activity in the rostral anterior cingulate cortex of mice
Hoot, M. R., Sim‐Selley, L. J., Poklis, J. L., Abdullah, R. A., Scoggins, K. L., Selley, D. E., & Dewey, W. L. (2010) · Brain Research · doi:10.1016/j.brainres.2010.03.105 · Cited by 34
Parallel spinal pathways generate the middle-latency N1 and the late P2 components of the laser evoked potentials
Valeriani, M., Pera, D. L., Restuccia, D., Armas, L. D., Miliucci, R., Betti, V., Vigevano, F., & Tonali, P. A. (2007) · Clinical Neurophysiology · doi:10.1016/j.clinph.2007.01.015 · Cited by 32
Are Functional Brain Alterations Present in Low Back Pain? A Systematic Review of EEG Studies
Schouppe, S., Oosterwijck, S. V., Danneels, L. A., Damme, S. V., & Oosterwijck, J. V. (2019) · Journal of Pain · doi:10.1016/j.jpain.2019.06.010 · Cited by 30
Habituation of phase-locked local field potentials and gamma-band oscillations recorded from the human insula
Liberati, G., Algoet, M., Klöcker, A., Santos, S. F., Ribeiro-Vaz, J. G., Raftopoulos, C., & Mouraux, A. (2018) · Scientific Reports · doi:10.1038/s41598-018-26604-0 · Cited by 29
The Reorganization of Insular Subregions in Individuals with Below-Level Neuropathic Pain following Incomplete Spinal Cord Injury
Li, X., Wang, L., Chen, Q., Hu, Y., Du, J., Chen, X., Zheng, W., Lu, J., & Chen, N. (2020) · Neural Plasticity · doi:10.1155/2020/2796571 · Cited by 30
Tonic pain alters functional connectivity of the descending pain modulatory network involving amygdala, periaqueductal gray, parabrachial nucleus and anterior cingulate cortex
Meeker, T. J., Schmid, A., Keaser, M. L., Khan, S. A., Gullapalli, R. P., Dorsey, S. G., Greenspan, J. D., & Seminowicz, D. A. (2022) · NeuroImage · doi:10.1016/j.neuroimage.2022.119278 · Cited by 34
The Sweetest Taboo: Functional Neurobiology of Human Sexuality in Relation to Pleasure
Georgiadis, J. R., & Kortekaas, R. (2009) · Oxford University Press eBooks · doi:10.1093/oso/9780195331028.003.0013 · Cited by 28
A Comparison of the Effects of Burst and Tonic Spinal Cord Stimulation on Hyperalgesia and Physical Activity in an Animal Model of Neuropathic Pain
Gong, W.-Y., Johanek, L. M., & Sluka, K. A. (2016) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000001161 · Cited by 28
Experiencing Pain in the Presence of Others: A Structured Experimental Investigation of Older Adults
Gallant, N. L., & Hadjistavropoulos, T. (2017) · Journal of Pain · doi:10.1016/j.jpain.2016.12.009 · Cited by 28
Filtering the reality: Functional dissociation of lateral and medial pain systems during sleep in humans
Bastuji, H., Mazza, S., Perchet, C., Frot, M., Mauguı̀ere, F., Magnin, M., & Garcı́a-Larrea, L. (2011) · Human Brain Mapping · doi:10.1002/hbm.21390 · Cited by 36
Pain and sleep: From reaction to action
Mazza, S., Magnin, M., & Bastuji, H. (2012) · Neurophysiologie Clinique · doi:10.1016/j.neucli.2012.05.003 · Cited by 30
The Importance of Psychosocial Influences On Chronic Pain
Main, C. J. (2013) · Pain Management · doi:10.2217/pmt.13.49 · Cited by 27
The Locus Coeruleus in Chronic Pain
España, J. C., Mohan, A., & Vanneste, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25168636 · Cited by 26
NMDA or Non-NMDA Receptor Antagonism Within the Amygdaloid Central Nucleus Suppresses the Affective Dimension of Pain in Rats: Evidence for Hemispheric Synergy
Spuz, C. A., & Borszcz, G. S. (2012) · Journal of Pain · doi:10.1016/j.jpain.2011.12.007 · Cited by 26
Pain-preferential thalamocortical neural dynamics across species
Tu, Y., Li, Z., Zhang, L., Zhang, H., Bi, Y., Yue, L., & Hu, L. (2023) · Nature Human Behaviour · doi:10.1038/s41562-023-01714-6 · Cited by 26
A Functional Magnetic Resonance Imaging Study to Investigate the Utility of a Picture Imagination Task in Investigating Neural Responses in Patients with Chronic Musculoskeletal Pain to Daily Physical Activity Photographs
Taylor, A., Harris, A. D., Varnava, A., Phillips, R., Taylor, J., Hughes, O., Wilkes, A. R., Hall, J. E., & Wise, R. G. (2015) · PLoS ONE · doi:10.1371/journal.pone.0141133 · Cited by 27
Pre-treatment Ongoing Cortical Oscillatory Activity Predicts Improvement of Tinnitus After Partial Peripheral Reafferentation With Hearing Aids
Han, J. J., Ridder, D. D., Vanneste, S., Chen, Y., Koo, J., & Song, J. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00410 · Cited by 26
Pain Induced Changes in Brain Oxyhemoglobin: A Systematic Review and Meta-Analysis of Functional NIRS Studies
Hall, M., Kidgell, D. J., Perraton, L. G., Morrissey, J., & Jaberzadeh, S. J. (2020) · Pain Medicine · doi:10.1093/pm/pnaa453 · Cited by 25
Neuroimaging Assessment of Pain
Luo, J., Zhu, H.-Q., Gou, B., & Wang, X. (2022) · Neurotherapeutics · doi:10.1007/s13311-022-01274-z · Cited by 28
Acoustic noise in functional magnetic resonance imaging reduces pain unpleasantness ratings
Boyle, Y., Bentley, D. E., Watson, A., & Jones, A. K. P. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.01.025 · Cited by 25
Self-citation
Brain activity changes associated with pain perception variability
Crawford, L. S., Mills, E. P., Meylakh, N., Macey, P. M., Macefield, V. G., & Henderson, L. A. (2022) · Cerebral Cortex · doi:10.1093/cercor/bhac332 · Cited by 23
Prefrontal Hemodynamic Changes Associated with Subjective Sense of Occlusal Discomfort
Ono, Y., Kobayashi, G., Hayama, R., Ikuta, R., Onozouka, M., Wake, H., Shimada, A., Shibuya, T., & Tamaki, K. (2015) · BioMed Research International · doi:10.1155/2015/395705 · Cited by 23
Social cognitive neuroscience: A review of core systems.
Doré, B., Zerubavel, N., & Ochsner, K. N. (2014) · American Psychological Association eBooks · doi:10.1037/14341-022 · Cited by 23
Motor Cortex Stimulation in Patients Suffering from Chronic Neuropathic Pain: Summary of Expert Meeting and Premeeting Questionnaire, Combined with Literature Review
Kurt, E., Henssen, D. J. H. A., Steegers, M. A. H., Staal, M. J., Beese, U., Maarrawi, J., Pirotte, B. J. M., Garcı́a-Larrea, L., Rasche, D., Vesper, J., et al. (2017) · World Neurosurgery · doi:10.1016/j.wneu.2017.08.168 · Cited by 23
Persistent Valence Representations by Ensembles of Anterior Cingulate Cortex Neurons
Caracheo, B. F., Grewal, J. J. S., & Seamans, J. K. (2018) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2018.00051 · Cited by 27
Burst and Tonic Spinal Cord Stimulation in the Mechanical Conflict-Avoidance System: Cognitive-Motivational Aspects
Meuwissen, K. P. V., van Beek, M., & Joosten, E. A. J. (2019) · Neuromodulation Technology at the Neural Interface · doi:10.1111/ner.12955 · Cited by 23
Cingulate Cortex and Pain Architecture
Vogt, B. A. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-374245-2.00021-8 · Cited by 22
Nociceptive Processing in the Cerebral Cortex
Treede, R., & Apkarian, A. V. (2008) · Elsevier eBooks · doi:10.1016/b978-012370880-9.00188-2 · Cited by 23
Brain activation associated with ratings of the hedonic component of thermal sensation during whole-body warming and cooling
Farrell, M. J., Johnson, J. M., McAllen, R. M., Zamarripa, F., Denton, D. A., Fox, P. T., & Egan, G. F. (2010) · Journal of Thermal Biology · doi:10.1016/j.jtherbio.2010.11.003 · Cited by 25
An fMRI Study of Affective Congruence across Visual and Auditory Modalities
Gao, C., Weber, C. E., Wedell, D. H., & Shinkareva, S. V. (2020) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_01553 · Cited by 24
A nigra–subthalamic circuit is involved in acute and chronic pain states
Cui, Y., Jia, T., Luan, Y., Zhang, X., Xiao, C., & Zhou, C. (2022) · Pain · doi:10.1097/j.pain.0000000000002588 · Cited by 22
Regional brain responses in humans during body heating and cooling
Farrell, M. J. (2016) · Temperature · doi:10.1080/23328940.2016.1174794 · Cited by 22
The Role of Cingulate Cortex in Vicarious Pain
Yesudas, E. H., & Lee, T. M. C. (2015) · BioMed Research International · doi:10.1155/2015/719615 · Cited by 24
Naproxen Effects on Brain Response to Painful Pressure Stimulation in Patients with Knee Osteoarthritis: A Double-blind, Randomized, Placebo-controlled, Single-dose Study
Giménez, M., Pujol, J., Ali, Z., López‐Solà, M., Contreras‐Rodríguez, O., Deus, J., Ortiz, H., Soriano‐Mas, C., Llorente‐Onaindia, J., & Monfort, J. (2014) · The Journal of Rheumatology · doi:10.3899/jrheum.131367 · Cited by 21
Meditation as an Adjunct to the Management of Acute Pain
Wipplinger, F., Holthof, N., Andereggen, L., Urman, R. D., Luedi, M. M., & Bello, C. (2023) · Current Pain and Headache Reports · doi:10.1007/s11916-023-01119-0 · Cited by 20
Epidermal expression of human TRPM8, but not of TRPA1 ion channels, is associated with sensory responses to local skin cooling
Weyer-Menkhoff, I., Pinter, A., Schlierbach, H., Schänzer, A., & Lötsch, J. (2019) · Pain · doi:10.1097/j.pain.0000000000001660 · Cited by 20
Hypnosis for cingulate-mediated analgesia and disease treatment
Trujillo‐Rodriguez, D., Faymonville, M. E., Vanhaudenhuyse, A., & Athena Demertzi, A. (2019) · Handbook of clinical neurology · doi:10.1016/b978-0-444-64196-0.00018-2 · Cited by 24
The “virtual lesion” approach to transcranial magnetic stimulation: studying the brain–behavioral relationships in experimental pain
Weissman‐Fogel, I., & Granovsky, Y. (2019) · PAIN Reports · doi:10.1097/pr9.0000000000000760 · Cited by 24
Modulation of cerebral cortex activity by acupuncture in patients with prolonged disorder of consciousness: An fNIRS study
Liu, Y., Sun, N. L., Xiong, J., Zhou, Y., Ye, X., Jiang, H., Guo, H., Zhi, N., Lu, J., He, P., et al. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1043133 · Cited by 19
Targeting Prefrontal Cortex Dysfunction in Pain
Kummer, K. K., & Sheets, P. L. (2024) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.123.002046 · Cited by 20
Functional-MRI evaluation of pain processing in chronic migraine with medication overuse
Chiapparini, L., Grazzi, L., Ferraro, S., Mandelli, M. L., Usai, S., Andrasik, F., Bruzzone, M. G., & Bussone, G. (2009) · Neurological Sciences · doi:10.1007/s10072-009-0077-z · Cited by 18
Empathy and Intersubjectivity
Decety, J., & Lamm, C. (2009) · Wiley eBooks · doi:10.1002/9780470478509.neubb002048 · Cited by 11
Neurosurgical Treatment of Pain
de Sola, R. G., & Pulido, P. (2022) · Brain Sciences · doi:10.3390/brainsci12111584 · Cited by 17
Characterizing functional modules in the human thalamus: coactivation-based parcellation and systems-level functional decoding
Boeken, O. J., Cieslik, E. C., Langner, R., & Markett, S. A. (2022) · Brain Structure and Function · doi:10.1007/s00429-022-02603-w · Cited by 18
Narrative review of current neuromodulation modalities for spinal cord injury
Medina, R., Ho, A., Reddy, R. D., Chen, J. L., & Castellanos, J. P. (2023) · Frontiers in Pain Research · doi:10.3389/fpain.2023.1143405 · Cited by 17
Increased activation of the pregenual anterior cingulate cortex to citalopram challenge in migraine: an fMRI study
Édes, A. E., McKie, S., Szabó, E., Kökönyei, G., Pap, D., Zsombók, T., Magyar, M., Csépány, É., Hullám, G., Szabó, Á., et al. (2019) · BMC Neurology · doi:10.1186/s12883-019-1478-0 · Cited by 19
An exploratory proton MRS examination of gamma-aminobutyric acid, glutamate, and glutamine and their relationship to affective aspects of chronic pain
Legarreta, M. D., Sheth, C. S., Prescot, A. P., Renshaw, P. F., McGlade, E., & Yurgelun-Todd, D. A. (2020) · Neuroscience Research · doi:10.1016/j.neures.2020.03.002 · Cited by 17
Cerebral hypoxia, missing cortical somatosensory evoked potentials and recovery of consciousness
Pfeiffer, G., Pfeifer, R., & Isenmann, S. (2014) · BMC Neurology · doi:10.1186/1471-2377-14-82 · Cited by 17
Infraslow Neurofeedback Training Alters Effective Connectivity in Individuals with Chronic Low Back Pain: A Secondary Analysis of a Pilot Randomized Placebo-Controlled Study
Adhia, D. B., Mani, R., Turner, P. R., Vanneste, S., & Ridder, D. D. (2022) · Brain Sciences · doi:10.3390/brainsci12111514 · Cited by 15
New insight into the neural mechanisms of migraine in adolescents: Relationships with sleep
Nahman‐Averbuch, H., Schneider, V. J., Lee, G. R., Peugh, J., Hershey, A. D., Powers, S. W., de Zambotti, M., Coghill, R. C., & King, C. D. (2022) · Headache The Journal of Head and Face Pain · doi:10.1111/head.14299 · Cited by 16
Separating analgesia from reward within the ventral tegmental area
Schifirnet, E., Bowen, S. E., & Borszcz, G. S. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.01.009 · Cited by 15
Neural responses to a modified Stroop paradigm in patients with complex chronic musculoskeletal pain compared to matched controls: an experimental functional magnetic resonance imaging study
Taylor, A., Harris, A. D., Varnava, A., Phillips, R., Hughes, O., Wilkes, A. R., Hall, J. E., & Wise, R. G. (2016) · BMC Psychology · doi:10.1186/s40359-016-0109-4 · Cited by 14
Spinal cord anatomy, pain, and spinal cord stimulation mechanisms
Dowlati, E. P. (2017) · Seminars in Spine Surgery · doi:10.1053/j.semss.2017.05.002 · Cited by 15
Hypnosis as an effective and inexpensive option to control pain in transcatheter ablation of cardiac arrhythmias
Barbero, U., Ferraris, F., Muro, M., Budano, C., Anselmino, M., & Gaïta, F. (2017) · Journal of Cardiovascular Medicine · doi:10.2459/jcm.0000000000000605 · Cited by 15
Auditory Cortex Stimulation for Tinnitus
Ridder, D. D., & Vanneste, S. (2010) · Springer eBooks · doi:10.1007/978-1-60761-145-5_90 · Cited by 15
#ItsNotInYourHead: A Social Media Campaign to Disseminate Information on Provoked Vestibulodynia
Brotto, L. A., Nelson, M. M. W., Barry, L., & Maher, C. (2020) · Archives of Sexual Behavior · doi:10.1007/s10508-020-01731-w · Cited by 15
The influence of repeated pain stimulation on the emotional aspect of pain: a preliminary study in healthy volunteers
Maeoka, H., Hiyamizu, M., Matsuo, A., & Morioka, S. (2015) · Journal of Pain Research · doi:10.2147/jpr.s86732 · Cited by 15
A Heuristic Pathophysiological Model of Tinnitus
Ridder, D. D. (2010) · Springer eBooks · doi:10.1007/978-1-60761-145-5_21 · Cited by 15
A mechanistic understanding of the relationship between skin innervation and chemotherapy-induced neuropathic pain
Meregalli, C., Monza, L., & Jongen, J. L. M. (2022) · Frontiers in Pain Research · doi:10.3389/fpain.2022.1066069 · Cited by 15
Human ventromedial prefrontal cortex lesions enhance the effect of expectations on pain perception
Motzkin, J. C., Hiser, J., Carroll, I. C., Wolf, R. C., Başkaya, M. K., Koenigs, M. R., & Atlas, L. Y. (2023) · Cortex · doi:10.1016/j.cortex.2023.04.017 · Cited by 16
The Mechanisms of Muscle Mass and Strength Increase during Strength Training
Lysenko, E. A., Виноградова, О. Л., & Popov, D. V. (2021) · Journal of Evolutionary Biochemistry and Physiology · doi:10.1134/s0022093021040104 · Cited by 17

Authors: Kulkarni, B., Bentley, D. E., Elliott, R., Youell, P., Watson, A., Derbyshire, S. W. G., Frackowiak, R. S. J., Friston, K. J., & Jones, A. K. P.
Affiliations: Salford Royal Hospital (GB)
University of Manchester (GB)
University of Pittsburgh (US)
National Hospital for Neurology and Neurosurgery (GB)
Corresponding author: Kulkarni, B.
ORCID: Elliott, R.
Watson, A.
Derbyshire, S. W. G.
Frackowiak, R. S. J.
Friston, K. J.
Jones, A. K. P.
Venue: European Journal of Neuroscience
Publisher: Wiley
Published: 2005-06
Volume: 21
Issue: 11
Pages: 3133-3142
ISSN: 0953-816X (ISSN-L)
1460-9568
DOI: 10.1111/j.1460-9568.2005.04098.x
OpenAlex: W2016341768
Cited by: 337
References: 90
Citations by year: 2026: 8 · 2025: 10 · 2024: 10 · 2023: 18 · 2022: 27 · 2021: 13 · 2020: 22 · 2019: 20 · 2018: 14 · 2017: 24 · 2016: 17 · 2015: 16 · 2014: 16 · 2013: 10 · 2012: 15
FWCI: 8.79
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 23 d)
Locations: European Journal of Neuroscience (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
Research Explorer (The University of Manchester) (submittedVersion)
Funders: Wellcome Trust
Topics: Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
Keywords: pain localization, pain unpleasantness, attentional modulation of pain, nociceptive processing, primary somatosensory cortex, inferior parietal cortex, orbitofrontal cortex, amygdala, hypothalamus, posterior insula
MeSH terms: Adult, Afferent Pathways, Attention, Brain, Brain Mapping, Emotions, Humans, Functional Laterality, Limbic System, Male, Nerve Fibers, Myelinated, Neurosecretory Systems, Nociceptors, Pain, Physical Stimulation, Somatosensory Cortex, Nerve Fibers, Unmyelinated, Positron-Emission Tomography

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Attention to pain localization and unpleasantness discriminates the functions of the medial and lateral pain systems.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks