Frontoparietal mechanisms supporting attention to location and intensity of painful stimuli
Open accessAbstract
Attention can profoundly shape the experience of pain. However, little is known about the neural mechanisms that support directed attention to nociceptive information. In the present study, subjects were cued to attend to either the spatial location or the intensity of sequentially presented pairs of painful heat stimuli during a delayed match-to-sample discrimination task. We hypothesized that attention-related brain activation would be initiated after the presentation of the attentional cue and would be sustained through the discrimination task. Conjunction analysis confirmed that bilateral portions of the posterior parietal cortex (intraparietal sulcus [IPS] and superior parietal lobule) exhibited this sustained activity during attention to spatial but not intensity features of pain. Analyses contrasting activation during spatial and intensity attention tasks revealed that the right IPS region of the posterior parietal cortex was consistently more activated across multiple phases of the spatial task. However, attention to either feature of the noxious stimulus was associated with activation of frontoparietal areas (IPS and frontal eye fields) as well as priming of the primary somatosensory cortex. Taken together, these results delineate the neural substrates that support selective amplification of different features of noxious stimuli for utilization in discriminative processes.
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Higher-order regions such as ACC, dACC, and PFC support the contextual meaning of pain.
“The contextual meaning of pain is then facilitated through activation of higher-order brain regions, including the anterior cingulate cortex (ACC), dorsal ACC (dACC), and prefrontal cortex (PFC).80–82”
From Mindfulness meditation-based pain relief: a mechanistic account (2016) · cites this paper as [81]
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- Authors
- Lobanov, O. V., Quevedo, A. S., Hadsel, M. S., Kraft, R. A., & Coghill, R. C.
- Affiliations
- Wake Forest University Health Sciences (US)
- Corresponding author
- Coghill, Robert C.
- Venue
- Pain
- Published
- 2013-09
- Volume
- 154
- Issue
- 9
- Pages
- 1758-1768
- ISSN
- 0304-3959 (ISSN-L)
- PMC
- PMC3755961
- OpenAlex
- W1972843439
- Cited by
- 65
- References
- 65
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 5 · 2023: 1 · 2022: 11 · 2021: 5 · 2020: 4 · 2019: 5 · 2018: 3 · 2017: 6 · 2016: 9 · 2015: 6 · 2014: 3 · 2013: 3
- FWCI
- 4.82
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Pain (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS039426)
- Topics
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Keywords
- spatial attention, nociception, posterior parietal cortex, intraparietal sulcus, superior parietal lobule, frontal eye field, primary somatosensory cortex, sustained attention, delayed matching-to-sample, thermal pain, attentional cueing
- MeSH terms
- Adult, Attention, Brain Mapping, Choice Behavior, Cues, Discrimination, Psychological, Female, Frontal Lobe, Hot Temperature, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Oxygen, Pain, Pain Measurement, Parietal Lobe, Psychophysics, Regression Analysis, Space Perception, Young Adult
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