Differential effects on the laser evoked potential of selectively attending to pain localisation versus pain unpleasantness
Abstract
Objective To determine the effects on the laser evoked potential (LEP) of selectively attending to affective (unpleasantness) versus sensory-discriminative (localisation) components of pain.Methods LEPs, elicited by painful CO2 laser stimulation of two areas of the right forearm, were recorded from 62 electrodes in 21 healthy volunteers, during three tasks that were matched for generalised attention: Localisation (report stimulus location), Unpleasantness (report stimulus unpleasantness), Control (report pain detection). LEP components are named by polarity, latency, and electrode.Results N300-T7 peak amplitude was significantly greater during Localisation than Unpleasantness. The difference in N300-T7 amplitude between Localisation and Control approached significance, suggesting an increased amplitude in Localisation compared with Control, rather than a reduced amplitude in Unpleasantness. Peak amplitude, latency, and topography of N300-FCz, P450, P600-800 (early P3) and P800-1000 (late P3) did not differ significantly between tasks.Conclusions These results suggest that the N300-T7 LEP peak reflects the activity of cerebral generators involved in the localisation of pain. The topography of N300-T7 is consistent with a source in contralateral secondary somatosensory cortex/insula and maybe primary somatosensory cortex.Significance This study confirms a role of the lateral pain system in the localisation of pain, and distinguishes it from stimulus novelty or attention.
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LEPs reflect temporally distinct cortical processes specifically evoked by the activation of Aδ-fibres and are differentially modulated by cognitive and pharmacological interventions.
“LEPs reflect temporally distinct cortical processes specifically evoked by the activation of Aδ‐fibres 31 and are differentially modulated by cognitive 32, 33, 34 and pharmacological 35 interventions.”
From The Analgesic Effect of Oxytocin in Humans: A Double‐Blind, Placebo‐Controlled Cross‐Over Study Using Laser‐Evoked Potentials (2016) · cites this paper as [32]
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- Authors
- Bentley, D. E., Watson, A., Treede, R.-D., Barrett, G., Youell, P. D., Kulkarni, B., & Jones, A. K. P.
- Affiliations
- University of Manchester (GB)
- Johannes Gutenberg University Mainz (DE)
- Defence Science and Technology Laboratory (GB)
- Corresponding author
- Bentley, D.E
- Venue
- Clinical Neurophysiology
- Publisher
- Elsevier BV
- Published
- 2004-08
- Volume
- 115
- Issue
- 8
- Pages
- 1846-1856
- ISSN
- 1388-2457 (ISSN-L)
- OpenAlex
- W2020216920
- Cited by
- 44
- References
- 46
- Citations by year
- 2025: 1 · 2022: 2 · 2021: 2 · 2020: 2 · 2018: 1 · 2017: 3 · 2016: 2 · 2015: 3 · 2014: 2 · 2013: 2 · 2012: 1
- FWCI
- 2.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Neurophysiology (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
- Keywords
- laser-evoked potentials, pain localization, pain unpleasantness, attentional modulation, P300, somatosensory cortex, insula, CO2 laser stimulation
- MeSH terms
- Adult, Analysis of Variance, Attention, Evoked Potentials, Somatosensory, Female, Humans, Lasers, Male, Pain, Pain Measurement, Reaction Time
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