The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Reduction in subthalamic 8–35 Hz oscillatory activity correlates with clinical improvement in Parkinson's disease
Abstract
Strong synchronization of neuronal activity occurs in the 8–35 Hz band in the subthalamic nucleus (STN) of patients with Parkinson's disease (PD) and is evident as oscillatory local field potential (LFP) activity. To test whether such synchronization may contribute to bradykinesia and rigidity, we sought correlations between the suppression of synchronization at 8–35 Hz in STN and the reduction in Parkinsonism with levodopa. LFPs were recorded on and off medication from STN deep‐brain stimulation electrodes in nine PD patients. LFP power was calculated over the frequencies of the most prominent spectral peak within the 8–35 Hz frequency band on each of 17 sides (off medication), and over the frequencies of any peak in the 60–90 Hz band, if present (seven sides, on medication). Levodopa‐induced reduction of LFP power over these two frequency ranges was then correlated with improvement in motor impairment as assessed by the Unified Parkinson's Disease Rating Scale (UPDRS). The reduction in peak activity in the 8–35 Hz band with levodopa positively correlated with the improvement in the contralateral hemibody motor UPDRS score with levodopa (r = 0.811, P < 0.001) as well as with hemibody subscores of akinesia‐rigidity (r = 0.835, P < 0.001), but not tremor. A trend for negative correlations was found between peak 60–90 Hz LFP power and UPDRS hemibody score, suggesting that positive correlations were relatively frequency‐specific. Our results support a link between levodopa‐induced improvements in bradykinesia and rigidity and reductions in population synchrony at frequencies < 35 Hz in the region of the STN in patients with PD.
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Cites
The primate subthalamic nucleus. II. Neuronal activity in the MPTP model of parkinsonism
Bergman, H., Wichmann, T., Karmon, B., & DeLong, M. R. (1994) · Journal of Neurophysiology · doi:10.1152/jn.1994.72.2.507 · Cited by 1,365
Dopamine Dependency of Oscillations between Subthalamic Nucleus and Pallidum in Parkinson's Disease
Brown, P., Oliviero, A., Mazzone, P., Insola, A., Tonali, P., & Di Lazzaro, V. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-03-01033.2001 · Cited by 1,172
Self-citationHalliday, D. M., Rosenberg, J. R., Amjad, A. M., Breeze, P., Conway, B. A., & Farmer, S. F. (1995) · Progress in Biophysics and Molecular Biology · doi:10.1016/s0079-6107(96)00009-0 · Cited by 1,107
Brown, P. (2003) · Movement Disorders · doi:10.1002/mds.10358 · Cited by 1,050
Self-citationEvent‐related beta desynchronization in human subthalamic nucleus correlates with motor performance
Kühn, A. A., Williams, D., Kupsch, A., Limousin, P., Hariz, M., Schneider, G., Yarrow, K., & Brown, P. (2004) · Brain · doi:10.1093/brain/awh106 · Cited by 740
Self-citationThe functions of the basal ganglia and the paradox of stereotaxic surgery in Parkinson's disease
Marsden, C. D., & Obeso, J. A. (1994) · Brain · doi:10.1093/brain/117.4.877 · Cited by 712
Dependence of subthalamic nucleus oscillations on movement and dopamine in Parkinson’s disease
Levy, R., Ashby, P., Hutchison, W. D., Lang, A. E., Lozano, A. M., & Dostrovsky, J. O. (2002) · Brain · doi:10.1093/brain/awf128 · Cited by 683
Nini, A., Feingold, A., Slovin, H., & Bergman, H. (1995) · Journal of Neurophysiology · doi:10.1152/jn.1995.74.4.1800 · Cited by 648
Abnormal spontaneous activity of globus pallidus neurons in monkeys with MPTP-induced parkinsonism
Filion, M., & Tremblay, L. (1991) · Brain Research · doi:10.1016/0006-8993(91)90585-j · Cited by 639
Levy, R., Hutchison, W. D., Lozano, A. M., & Dostrovsky, J. O. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-20-07766.2000 · Cited by 615
Cited by
Poewe, W., Seppi, K., Tanner, C. M., Halliday, G. M., Brundin, P., Volkmann, J., Schrag, A.-E., & Lang, A. E. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.13 · Cited by 5,415
Pathological synchronization in Parkinson's disease: networks, models and treatments
Hammond, C., Bergman, H., & Brown, P. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.05.004 · Cited by 1,629
Self-citationAdaptive deep brain stimulation in advanced Parkinson disease.
Little, S., Pogosyan, A., Neal, S., Zavala, B., Zrinzo, L., Hariz, M., Foltynie, T., Limousin, P., Ashkan, K., FitzGerald, J., et al. (2013) · Annals of Neurology · doi:10.1002/ana.23951 · Cited by 1,374
Self-citationNew insights into the relationship between dopamine, beta oscillations and motor function
Jenkinson, N., & Brown, P. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.09.003 · Cited by 659
Self-citationKühn, A. A., Tsui, A., Aziz, T., Ray, N., Brücke, C., Kupsch, A., Schneider, G.-H., & Brown, P. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2008.11.008 · Cited by 630
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Metadata
- Authors
- Kühn, A. A., Kupsch, A., Schneider, G., & Brown, P.
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 2006-04
- Volume
- 23
- Issue
- 7
- Pages
- 1956-1960
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- OpenAlex
- W1498617277
- Cited by
- 892
- References
- 22
- FWCI
- 13.80
- Type
- journal article
- Language
- en
- Open access
- closed
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