D2 dopamine modulation of corticoaccumbens synaptic responses changes during adolescence
Open accessAbstract
Dopaminergic afferents from the ventral tegmental area (VTA) modulate information processing in the nucleus accumbens (NA), a brain region critical for motivation and reward mechanisms. In NA medium spiny neurons (MSNs) from young rats, D(2) agonists have been shown to decrease the amplitude of corticoaccumbens synaptic responses. As several dopamine-related functions change during adolescence, we assessed the D(2) modulation of cortical inputs with whole-cell recordings in slices obtained from adult and preadolescent rats. The D(2) agonist quinpirole (5 microM) decreased synaptic response of NA MSNs to electrical cortical stimulation in slices from preadolescent rats. In slices from adult rats, however, quinpirole increased both the amplitude of evoked synaptic responses and the frequency of spontaneous synaptic events. These effects were blocked by the GABA-A antagonist picrotoxin (50 microM), revealing a D(2)-mediated decrease These results suggest that D(2) receptors modulate NA neurons differently in young and adult rats, due to the emergence of a D(2)-facilitated GABA component in corticoaccumbens responses during adolescence.
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In the nucleus accumbens, D1 and D2 receptor responses are immature, resulting in decreased synaptic interaction between this region and the prefrontal cortex.
“In the nucleus accumbens, D1 and D2 receptor responses are also immature, resulting in decreased synaptic interaction between this region and the prefrontal cortex (Benoit-Marand & O'Donnell, 2008; Fig.4).”
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- Authors
- Benoit‐Marand, M., & O'Donnell, P.
- Affiliations
- University of Maryland, Baltimore (US)
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 2008-03
- Volume
- 27
- Issue
- 6
- Pages
- 1364-1372
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- PMC
- PMC2613327
- OpenAlex
- W2035575730
- Cited by
- 45
- References
- 2
- Citations by year
- 2024: 2 · 2023: 1 · 2022: 3 · 2021: 1 · 2020: 3 · 2018: 3 · 2017: 2 · 2016: 7 · 2015: 3 · 2014: 3 · 2013: 5 · 2012: 1
- FWCI
- 1.59
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- European Journal of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion)
- Funders
- U.S. Public Health Service
- National Institute of Mental Health (MH60131, R01MH060131)
- National Institute on Drug Abuse (R01DA014020, DA14020)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- dopamine D2 receptor, nucleus accumbens, medium spiny neurons, adolescence, quinpirole, GABAA receptor, picrotoxin, ventral tegmental area, synaptic plasticity, reward processing
- MeSH terms
- Age Factors, Animals, Cerebral Cortex, Dopamine, gamma-Aminobutyric Acid, Male, Neural Pathways, Nucleus Accumbens, Synapses, Rats, Sprague-Dawley, Receptors, Dopamine D2, Dopamine Agonists, Excitatory Postsynaptic Potentials, Rats
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