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Cited by 28Visual perception and processing mechanismsMotor Control and AdaptationVestibular and auditory disorders

Characterization of oculomotor and visual activities in the primate pedunculopontine tegmental nucleus during visually guided saccade tasks

Okada, Ken‐Ichi, Kobayashi, Yasushi·2009·European Journal of Neuroscience
DOI 10.1111/j.1460-9568.2009.07009.x
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Abstract

The pedunculopontine tegmental nucleus (PPTN) has anatomical connections with numerous visuomotor areas including the basal ganglia, thalamus, superior colliculus and frontal eye field. Although many anatomical and physiological studies suggest a role for the PPTN in the control of conditioned behavior and associative learning, the detailed characteristics of saccade‐ and visual‐related activities of PPTN neurons remain unclear. We recorded the activity of PPTN neurons in monkeys (Macaca fuscata ) during visually guided saccade tasks, and examined the response properties of saccade‐ and visual‐related activities such as time course, direction selectivity and contextual modulation. Saccade‐related activity occurred either during saccade execution or after saccade end. The preferred directions of the neuronal activity were biased toward the contralateral and upward sides. Half of the saccade‐related neurons showed activity modulation only for task saccades and not for spontaneous saccades outside the task. Visually‐responsive neurons responded with short latencies. Some responded to the appearance of the visual stimulus in a directionally selective manner, and others responded to both the appearance and disappearance of the visual stimulus in a directionally non‐selective manner. Many of these neurons exhibited distinct visual responses to the appearance of two different stimuli presented under different stages of the task, whereas a population of the neurons responded equally to the disappearance of the two stimuli. Thus, many PPTN neurons exhibited context‐dependent activity related to the visuomotor events, consistent with a role in controlling conditioned behavior.

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Crossref · 10.1111/j.1460-9568.2009.07009.x

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  • Cholinergic input from the pedunculopontine tegmental nucleus strongly innervates the macaque superior colliculus, and its neurones are active during saccade tasks and directly stimulate superior colliculus neurones to facilitate saccadic initiation.

    “Furthermore, cholinergic input from the PPT strongly innervates the macaque SC (53), and neurones in the PPT have also been shown to be active in monkeys during saccade tasks (54) and to directly stimulate SC neurones and facilitate the initiation of saccadic eye movements (55).”

    From Comparative Perspectives on Oxytocin and Vasopressin Receptor Research in Rodents and Primates: Translational Implications (2016) · cites this paper as [54]

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Authors
Okada, K., & Kobayashi, Y.
Affiliations
  • The University of Osaka (JP)
  • Japan Science and Technology Agency (JP)
ORCID
Venue
European Journal of Neuroscience
Publisher
Wiley
Published
2009-11-30
Volume
30
Issue
11
Pages
2211-2223
ISSN
  • 0953-816X (ISSN-L)
  • 1460-9568
DOI
10.1111/j.1460-9568.2009.07009.x
OpenAlex
W2091505459
Cited by
28
References
56
Citations by year
2026: 1 · 2024: 1 · 2022: 3 · 2021: 2 · 2020: 3 · 2019: 1 · 2016: 5 · 2015: 4 · 2014: 2 · 2013: 2 · 2012: 1
FWCI
0.65
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • European Journal of Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Ministry of Education, Science and Technology
  • Japan Science and Technology Agency
  • National Institute for Physiological Sciences
  • Precursory Research for Embryonic Science and Technology
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
  • Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
Keywords
pedunculopontine nucleus, visually guided saccades, direction selectivity, visual response properties, conditioned behavior, oculomotor control, superior colliculus, frontal eye field, basal ganglia, thalamus, single-unit recording, rhesus monkeys
MeSH terms
Action Potentials, Animals, Attention, Female, Fixation, Ocular, Macaca fascicularis, Male, Neurons, Neuropsychological Tests, Orientation, Photic Stimulation, Psychomotor Performance, Reaction Time, Saccades, Time Factors, Visual Fields, Visual Perception, Pedunculopontine Tegmental Nucleus

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