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Expression pattern of miR‐146a, an inflammation‐associated microRNA, in experimental and human temporal lobe epilepsy
Abstract
Increasing evidence supports the involvement of inflammatory and immune processes in temporal lobe epilepsy (TLE). MicroRNAs (miRNA) represent small regulatory RNA molecules that have been shown to act as negative regulators of gene expression controlling different biological processes, including immune‐system homeostasis and function. We investigated the expression and cellular distribution of miRNA‐146a (miR‐146a) in a rat model of TLE as well as in human TLE. miR‐146a analysis in rat hippocampus was performed by polymerase chain reaction and immunocytochemistry at 1 week and 3–4 months after induction of status epilepticus (SE). Prominent upregulation of miR‐146a activation was evident at 1 week after SE and persisted in the chronic phase. The miR‐146a expression was confirmed to be present in reactive astrocytes. In human TLE with hippocampal sclerosis, increased astroglial expression of miR‐146a was observed mainly in regions where neuronal cell loss and reactive gliosis occurred. The increased and persistent expression of miR‐146a in reactive astrocytes supports the possible involvement of miRNAs in the modulation of the astroglial inflammatory response occurring in TLE and provides a target for future studies aimed at developing strategies against pro‐epileptogenic inflammatory signalling.
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“miRNA-146a is expressed in human brain in astrocytes which may be key targets in the regulation of this miRNA in response to inflammatory molecules [19], [20].”
From MicroRNA-146a: A Key Regulator of Astrocyte-Mediated Inflammatory Response (2012) · cites this paper as [20]
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Taganov, K. D., Boldin, M. P., Chang, K.-J., & Baltimore, D. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605298103 · Cited by 4,317
MicroRNAs and immunity: Novel players in the regulation of normal immune function and inflammation
Sonkoly, E., Ståhle, M., & Pivarcsi, A. (2008) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2008.01.005 · Cited by 523 · cited 2×
“in various human pathologies associated with activation of inflammatory responses (Lukiw et al., 2008; Nakasa et al., 2008; Pauley et al., 2008; Sonkoly et al., 2008).”
BackgroundLukiw, W. J., Zhao, Y., & Cui, J. G. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m805371200 · Cited by 441
Research works printed but not linked: 30
- 10.1046/j.1460-9568.2000.00131.x · DOI
- 10.1007/s004010000296 · DOI
- 10.1046/j.0953-816x.2001.01779.x · DOI
- 10.1046/j.1528-1157.2003.54802.x · DOI
- 10.1016/j.nbd.2007.01.015 · DOI
- 10.1007/s00401-006-0187-0 · DOI
- 10.1016/j.neuroscience.2008.06.073 · DOI
- 10.1016/j.molimm.2009.02.013 · DOI
- 10.1038/ng.204 · DOI
- 10.1146/annurev.neuro.29.051605.112839 · DOI · Paper page
- 10.1046/j.1460-9568.2001.01428.x · DOI
- 10.1523/JNEUROSCI.2766-06.2006 · DOI · Paper page
- 10.1046/j.0953-816x.2001.01778.x · DOI
- 10.4049/jimmunol.0900707 · DOI · Paper page
- 10.1038/jcbfm.2009.186 · DOI
- 10.1369/jhc.2007.950170 · DOI · Paper page
- Maroso M., 2009, Activation of Toll‐like/RAGE Receptor Signalling During Seizures: a Novel Target of Pharmacological Intervention
- 10.1002/art.23429 · DOI
- 10.1371/journal.pone.0006309 · DOI
- 10.1186/ar2493 · DOI
- 10.1016/j.jaut.2009.02.012 · DOI
- 10.1016/j.cyto.2008.07.016 · DOI
- 10.1016/j.nbd.2007.08.012 · DOI
- 10.1136/ard.2008.100289 · DOI · Paper page
- 10.1586/14737175.4.6.973 · DOI
- Tsai L.M., 2009, MicroRNAs in common diseases and potential therapeutic applications, Clin. Exp. Pharmacol. Physiol.
- 10.1111/j.1528-1167.2005.00298.x · DOI
- 10.1111/j.1528-1167.2008.01490.x · DOI · Paper page
- 10.1111/j.0013-9580.2004.09004.x · DOI
- 10.1016/S0896-6974(05)80120-3 · DOI
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Sorted by citations
The impact of microglial activation on blood-brain barrier in brain diseases
da Fonseca, A. C. C., Matias, D., Garcia, C., Amaral, R., Geraldo, L. H., Freitas, C., & Lima, F. R. S. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00362 · Cited by 572
MicroRNA-146a: A Key Regulator of Astrocyte-Mediated Inflammatory Response
Iyer, A., Zurolo, E., Prabowo, A., Fluiter, K., Spliet, W. G. M., van Rijen, P. C., Gorter, J. A., & Aronica, E. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044789 · Cited by 330
Self-citationGhose, J., Sinha, M., Das, E., Jana, N. R., & Bhattacharyya, N. P. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023837 · Cited by 98
Fractalkine/CX 3 CL 1 modulates GABAA currents in human temporal lobe epilepsy
Roseti, C., Fucile, S., Lauro, C., Martinello, K., Bertollini, C., Esposito, V., Mascia, A., Catalano, M., Aronica, E., Limatola, C., et al. (2013) · Epilepsia · doi:10.1111/epi.12354 · Cited by 92
Self-citationBrain cell-specific origin of circulating microRNA biomarkers in experimental temporal lobe epilepsy
Brindley, E., Heiland, M., Mooney, C., Diviney, M., Mamad, O., Hill, T. D. M., Yan, Y., Venø, M. T., Reschke, C. R., Batool, A., et al. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1230942 · Cited by 21
Metadata
- Authors
- Aronica, E., Fluiter, K., Iyer, A., Zurolo, E., Vreijling, J., Van Vliet, E. A., Baayen, J. C., & Gorter, J. A.
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 2010-03
- Volume
- 31
- Issue
- 6
- Pages
- 1100-1107
- ISSN
- 0953-816X
- 1460-9568
- Cited by
- 268
- References
- 3
- Language
- en
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