An NF-κB-sensitive Micro RNA-146a-mediated Inflammatory Circuit in Alzheimer Disease and in Stressed Human Brain Cells
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CFH has been shown to be targeted by miR-146a and down-regulated in Alzheimer's disease and in Herpes simplex virus type 1 infection.
“Interestingly, this gene has been shown to be targeted by miR-146a and down-regulated in Alzheimer's disease as well as in other diseases such as Herpes simplex virus type1 infection [47], [48].”
From MicroRNA 146a (miR-146a) Is Over-Expressed during Prion Disease and Modulates the Innate Immune Response and the Microglial Activation State (2012) · cites this paper as [47]
MiR-146a serves as a classical NF-κB-induced negative-feedback regulator; elevated miR-146a in microglia acts to inhibit IRAK1 and TRAF6.
“MiR-146a serves as a classical NF-κB–induced negative-feedback regulator. Elevated miR-146a in microglia acts to inhibit IRAK1 and TRAF6 (Fan et al., 2020; Lukiw et al., 2008; Saba et al., 2012; Saba et al., 2014).”
From Cell-specific MicroRNA networks orchestrate the pathogenesis of Alzheimer’s disease (2026) · cites this paper as Lukiw et al., 2008
Intranasal administration of miR-146a mimics improves pathological and behavioral outcomes in transgenic AD models.
“Intranasal administration of miR-146a mimics has been reported to improve pathological and behavioral outcomes in transgenic AD models, highlighting the therapeutic potential of glial miRNA modulation (Fan et al., 2020; Lukiw et al., 2008).”
From Cell-specific MicroRNA networks orchestrate the pathogenesis of Alzheimer’s disease (2026) · cites this paper as Lukiw et al., 2008
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Cites
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Research works printed but not linked: 4
- Lukiw, W. J., and Bazan, N. G. (2006) Biochem. Soc. Trans. 34, 1277-1282
- Taganov, K. D., Boldin, M. P., Chang, K. J., and Baltimore, D. (2006) Proc. Natl. Acad. Sci. U. S. A. 103, 12481-12486
- He ´bert, S. S., Horre ´, K., Nicolaï, L., Papadopoulou, A. S., Mandemakers, W., Silahtaroglu, A. N., Kauppinen, S., Delacourte, A., and De Strooper, B. (2008) Proc. Natl. Acad. Sci. U. S. A. 105, 6415-6420
- O'Connell, R. M., Taganov, K. D., Boldin, M. P., Cheng, G., and Baltimore, D. (2007) Proc. Natl. Acad. Sci. U. S. A. 104, 1604 -1609
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Zhang, W., Xiao, D., Mao, Q., & Xia, H. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01486-5 · Cited by 1,668 · see citing works
“Study using APOE4 target replacement mice revealed that APOE4 can increase the expression of miRNA146a,(178) which was found to be highly expressed in AD, reducing the expression of its target protein complement factor H, an important repressor of the inflammatory response of the brain.(179) Using astrocyte differenti…”
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Lardenoije, R., Iatrou, A., Kenis, G., Kompotis, K., Steinbusch, H. W. M., Mastroeni, D., Coleman, P., Lemere, C. A., Hof, P. R., van den Hove, D. L. A., et al. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.05.002 · Cited by 381 · see citing works
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Iyer, A., Zurolo, E., Prabowo, A., Fluiter, K., Spliet, W. G. M., van Rijen, P. C., Gorter, J. A., & Aronica, E. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044789 · Cited by 330 · see citing works
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Huang, C., Liu, X.-J., QunZhou, Xie, J., Ma, T.-T., Meng, X.-M., & Li, J. (2016) · International Immunopharmacology · doi:10.1016/j.intimp.2016.01.009 · Cited by 160 · see citing works
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ccf-mtDNA as a Potential Link Between the Brain and Immune System in Neuro-Immunological Disorders
Gambardella, S., Limanaqi, F., Ferese, R., Biagioni, F., Campopiano, R., Centonze, D., & Fornai, F. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01064 · Cited by 141 · see citing works
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Müller, M., Kuiperij, H. B., Versleijen, A. A. M., Chiasserini, D., Farotti, L., Baschieri, F., Parnetti, L., Struyfs, H., De Roeck, N., Luyckx, J., et al. (2016) · Journal of Alzheimer’s Disease · doi:10.3233/jad-160038 · Cited by 41 · see citing works
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Cell-specific MicroRNA networks orchestrate the pathogenesis of Alzheimer’s disease
Donepudi, K., Eadha, S., Rodarte, D., Sharma, B., & Kumar, S. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103211
- Authors
- Lukiw, W. J., Zhao, Y., & Cui, J. G.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2008-11
- Volume
- 283
- Issue
- 46
- Pages
- 31315-31322
- ISSN
- 0021-9258
- Cited by
- 380
- References
- 2
- Language
- en
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