The DOI matches its Crossref record; 122 of the 122 references it cites were found in a registry or an index.
Neurogenesis and affective disorders
Abstract
The neurogenesis hypothesis of depression was originally formed upon the demonstration that stress impacts levels of adult neurogenesis in the hippocampus. Since then much work has established that newborn neurons in the dentate gyrus are required for mediating some of the beneficial effects of antidepressant treatment. Recent studies combining behavioral, molecular and electrophysiological approaches have attempted to make sense of the role young neurons play in modulating mood by demonstrating a potential role in regulating the circuitry in the brain that underlies depression. Here we discuss the work that led to the neurogenesis hypothesis of depression, and the subsequent studies that have sought to test this hypothesis. We also discuss different animal models of depression that have been used to test the role of neurogenesis in mediating the antidepressant response.
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The chronic mild stress (CMS) model of depression: History, evaluation and usage
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The Genetics of Major Depression
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The effects of aging in the hippocampus and cognitive decline
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Depression in Parkinson disease—epidemiology, mechanisms and management
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The neurobiology of depression and antidepressant action
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Metadata
- Authors
- Samuels, B. A., & Hen, R.
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 2011-03
- Volume
- 33
- Issue
- 6
- Pages
- 1152-1159
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- OpenAlex
- W1815206142
- Cited by
- 290
- References
- 122
- FWCI
- 11.86
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
