The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Smoking is a major risk factor for anastomotic leak in patients undergoing low anterior resection
Abstract
Aim To examine modifiable risk factors for anastomotic leak in patients undergoing low anterior resection. Method In total 233 patients undergoing low anterior resection for benign and malignant disease over a 10-year period at a single surgical unit were identified from a prospective database. The relationships between anastomotic leak and 17 variables were examined, including patient demographics, operative technique, tumour pathology, preoperative physiological function and smoking status. Results The majority (91%) of operations were carried out for rectal cancers, and 24 procedures (10%) were performed with laparoscopic assistance. The overall anastomotic leak rate was 14% (33/233). Patients with anastomotic leak had higher 30-day mortality (6%vs 1%, P Conclusion Smoking and the presence of metastatic disease are major risk factors for the development of anastomotic leak following low anterior resection.
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Møller, A. M., Villebro, N., Pedersen, T., & Tønnesen, H. (2002) · The Lancet · doi:10.1016/s0140-6736(02)07369-5 · Cited by 1,126
Risk factors for anastomotic leakage after resection of rectal cancer
Rullier, E., Laurent, C., Garrelon, J. L., Michel, P., Saric, J., & Parneix, M. (1998) · Journal of British Surgery · doi:10.1046/j.1365-2168.1998.00615.x · Cited by 895
Risk factors for anastomotic failure after total mesorectal excision of rectal cancer
Peeters, K. C. M. J., Tollenaar, R. A. E. M., Marijnen, C. A. M., Klein Kranenbarg, E., Steup, W. H., Wiggers, T., Rutten, H. J., & van de Velde, C. J. H. (2005) · Journal of British Surgery · doi:10.1002/bjs.4806 · Cited by 659
Anastomotic Leaks After Intestinal Anastomosis: It??s Later Than You Think
Hyman, N., Manchester, T. L., Osler, T., Burns, B., & Cataldo, P. A. (2007) · Annals of Surgery · doi:10.1097/01.sla.0000225083.27182.85 · Cited by 652
Risk factors for anastomotic leakage after anterior resection of the rectum
Matthiessen, P., Hallböök, O., Andersson, M., Rutegård, J., & Sjödahl, R. (2004) · Colorectal Disease · doi:10.1111/j.1463-1318.2004.00657.x · Cited by 597
Lindström, D., Azodi, O. S., Wladis, A., Tønnesen, H., Linder, S., Nåsell, H., Ponzer, S., & Adami, J. (2008) · Annals of Surgery · doi:10.1097/sla.0b013e3181889d0d · Cited by 530
McArdle, C. S., McMillan, D. C., & Hole, D. J. (2005) · British Journal of Surgery · doi:10.1002/bjs.5054 · Cited by 480
Law, W. L., & Chu, K. W. (2004) · Annals of Surgery · doi:10.1097/01.sla.0000133185.23514.32 · Cited by 475
Walker, K. G., Bell, S. W., Rickard, M. J. F. X., Mehanna, D., Dent, O. F., Chapuis, P. H., & Bokey, E. L. (2004) · Annals of Surgery · doi:10.1097/01.sla.0000133186.81222.08 · Cited by 451
Risk factors for anastomotic leakage after low anterior resection with total mesorectal excision
Law, W.-L., Chu, K.-W., Ho, J. W. C., & Chan, C.-W. (2000) · The American Journal of Surgery · doi:10.1016/s0002-9610(00)00252-x · Cited by 381
Cited by
Nowak, K., Dąbrowska, A., Mrugała, M., & Milnerowicz-Nabzdyk, E. (2026) · Journal of Clinical Medicine · doi:10.3390/jcm15072630 · Cited by 1
“This is notable because anastomotic leakage is considered a major life-threatening complication, reported in approximately 1–2% of segmental resections according to Richards et al. [15], and as high as 3–6% in the study by Abo et al. [16].”
Metadata
- Authors
- Richards, C. H., Campbell, V., Ho, C., Hayes, J., Elliott, T., & Thompson‐Fawcett, M.
- Affiliations
- University of Otago (NZ)
- Corresponding author
- Richards, C. H.
- Ho, C.
- Venue
- Colorectal Disease
- Publisher
- Wiley
- Published
- 2012-03-30
- Volume
- 14
- Issue
- 5
- Pages
- 628-633
- ISSN
- 1462-8910 (ISSN-L)
- 1463-1318
- OpenAlex
- W1906130644
- Cited by
- 64
- References
- 29
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 2 · 2023: 4 · 2022: 3 · 2021: 7 · 2020: 6 · 2019: 7 · 2018: 4 · 2017: 5 · 2016: 6 · 2015: 5 · 2014: 3 · 2013: 1 · 2012: 3
- FWCI
- 1.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Colorectal Disease (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Colorectal Cancer Surgical Treatments
- Health Sciences › Medicine › Oncology › Gastric Cancer Management and Outcomes
- Health Sciences › Medicine › Surgery › Esophageal Cancer Research and Treatment
- Keywords
- anastomotic leakage, low anterior resection, smoking, risk factors, rectal cancer, metastatic disease, 30-day mortality, length of hospital stay, laparoscopic surgery
- MeSH terms
- Adenoma, Adult, Aged, Aged, 80 and over, Colonic Neoplasms, Diverticulitis, Colonic, Female, Humans, Length of Stay, Male, Middle Aged, Neoplasm Metastasis, Rectal Neoplasms, Risk Factors, Smoking, Inflammatory Bowel Diseases, Multivariate Analysis, Confidence Intervals, Odds Ratio, Young Adult, Anastomotic Leak
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- The paper
- Richards, C. H., Campbell, V., Ho, C., Hayes, J., Elliott, T., & Thompson‐Fawcett, M. (2012). Smoking is a major risk factor for anastomotic leak in patients undergoing low anterior resection. Colorectal Disease. https://doi.org/10.1111/j.1463-1318.2011.02718.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
