Cited by 121Adipokines, Inflammation, and Metabolic DiseasesRegulation of Appetite and ObesityDiabetes, Cardiovascular Risks, and Lipoproteins

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Role of leptin in the cardiovascular and endocrine complications of metabolic syndrome

Correia, Marcelo L. G., Rahmouni, Kamal·2006·Diabetes, Obesity and Metabolism

DOI 10.1111/j.1463-1326.2005.00562.x

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Abstract

Aim: To review the potential role of leptin, hyperleptinaemia and leptin resistance in the cardiovascular and endocrine complications of metabolic syndrome. Methods: Review of literature listed in Medline. Results: Hyperleptinaemia is common in obesity and reflects increased adiposity and leptin resistance. Nevertheless, leptin resistance may not be complete as several actions of leptin, such as cardiovascular sympatho‐activation, might be preserved in obese subjects known to be resistant to the metabolic effects of leptin (i.e. selective leptin resistance). Notably, the renal and sympathetic actions of leptin may play an important role in the pathogenesis of hypertension related to obesity and metabolic syndrome. Furthermore, the lipotoxic effect of leptin resistance may cause insulin resistance and β cell dysfunction, increasing the risk of type 2 diabetes. Leptin has also been shown to possess proliferative, pro‐inflammatory, pro‐thrombotic, and pro‐oxidative actions. Conclusion: Hyperleptinaemia and leptin resistance may contribute to hypertension, impaired glucose metabolism, and pro‐atherogenic state in obesity and metabolic syndrome.

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Authors: Correia, M. L. G., & Rahmouni, K.
Affiliations: University of Iowa (US)
Corresponding author: Correia, Marcelo L. G.
ORCID: Correia, Marcelo L. G.
Rahmouni, Kamal
Venue: Diabetes, Obesity and Metabolism
Publisher: Wiley
Published: 2006-02-07
Volume: 8
Issue: 6
Pages: 603-610
ISSN: 1462-8902 (ISSN-L)
1463-1326
DOI: 10.1111/j.1463-1326.2005.00562.x
OpenAlex: W1976610229
Cited by: 121
References: 56
Citations by year: 2026: 1 · 2025: 2 · 2024: 4 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 4 · 2019: 1 · 2018: 3 · 2017: 4 · 2016: 8 · 2015: 2 · 2014: 7 · 2013: 6 · 2012: 7
FWCI: 1.80
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Diabetes Obesity and Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords: leptin, hyperleptinemia, leptin resistance, metabolic syndrome, obesity, hypertension, cardiovascular complications, insulin resistance, beta-cell dysfunction, type 2 diabetes, atherosclerosis, inflammation, thrombosis, oxidative stress, sympathetic activation
MeSH terms: Animals, Blood Pressure, Diabetes Mellitus, Type 2, Drug Resistance, Humans, Hypertension, Insulin Resistance, Obesity, Leptin, Metabolic Syndrome, Atherosclerosis

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Role of leptin in the cardiovascular and endocrine complications of metabolic syndrome

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