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Cited by 416Diabetes Treatment and ManagementPharmacology and Obesity TreatmentDiabetes Management and Research

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Interim analysis of the effects of exenatide treatment on A1C, weight and cardiovascular risk factors over 82 weeks in 314 overweight patients with type 2 diabetes

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Blonde, L., Klein, E. J., Han, J., Zhang, B., Mac, S. M., Poon, T. H., Taylor, K. L., Trautmann, M. E., Kim, D. D., Kendall, D. M.·2006·Diabetes, Obesity and Metabolism
DOI 10.1111/j.1463-1326.2006.00602.x
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Abstract

Aim Exenatide, an incretin mimetic for the adjunct treatment of type 2 diabetes (DM2), reduced A1C and weight in 30-week placebo-controlled trials. This analysis examined the effects of exenatide on glycaemic control and weight over an 82-week period in patients with DM2 unable to achieve adequate glycaemic control with sulphonylurea (SU) and/or metformin (MET). Methods This interim analysis is of 314 patients who received exenatide in the 30-week placebo-controlled trials and subsequently in 52 weeks of open-label uncontrolled extension studies for 82 weeks of exenatide in total. Patients continued their SU and/or MET regimens throughout. Results Patients completed 82 weeks of exenatide treatment [n = 314, 63% M, age 56 +/- 10 years, weight 99 +/- 21 kg, body mass index 34 +/- 6 kg/m2, A1C 8.3 +/- 1.0% (mean +/- SD)]. Reduction in A1C from baseline to week 30 [-0.9 +/- 0.1% (mean +/- SE)] was sustained to week 82 (-1.1 +/- 0.1%), with 48% of patients achieving A1C Conclusion In summary, 82 weeks of adjunctive exenatide treatment in patients with DM2 treated with SU and/or MET resulted in sustained reduction in A1C and progressive reduction in weight, as well as improvement in some cardiovascular risk factors.

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Authors
Blonde, L., Klein, E. J., Han, J., Zhang, B., Mac, S. M., Poon, T. H., Taylor, K. L., Trautmann, M. E., Kim, D. D., & Kendall, D. M.
Affiliations
  • Ochsner Medical Center (US)
  • Eli Lilly (Germany) (DE)
Corresponding author
  • Mac, S. M.
  • Kim, D. D.
ORCID
Venue
Diabetes, Obesity and Metabolism
Publisher
Wiley
Published
2006-04-18
Volume
8
Issue
4
Pages
436-447
ISSN
  • 1462-8902 (ISSN-L)
  • 1463-1326
DOI
10.1111/j.1463-1326.2006.00602.x
OpenAlex
W2093738306
Cited by
416
References
31
Citations by year
2026: 1 · 2025: 2 · 2024: 7 · 2023: 3 · 2022: 3 · 2020: 5 · 2019: 6 · 2018: 8 · 2017: 7 · 2016: 15 · 2015: 15 · 2014: 19 · 2013: 24 · 2012: 45
FWCI
38.66
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Diabetes Obesity and Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Funders
Amylin Pharmaceuticals
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
  • Health Sciences › Medicine › Pharmacology (medical) › Pharmacology and Obesity Treatment
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords
exenatide, type 2 diabetes, incretin mimetics, HbA1c, glycemic control, weight loss, cardiovascular risk factors, sulfonylureas, metformin, adjunctive therapy, long-term treatment, nausea, hypoglycemia
MeSH terms
Exenatide, Adolescent, Adult, Aged, Blood Glucose, Blood Pressure, Body Weight, Cardiovascular Diseases, Diabetes Mellitus, Type 2, Diabetic Angiopathies, Double-Blind Method, Drug Therapy, Combination, Female, Glycated Hemoglobin, Humans, Hypoglycemic Agents, Lipids, Male, Metformin, Middle Aged, Peptides, Risk Factors, Sulfonylurea Compounds, Venoms, Weight Loss, Overweight

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