Cited by 151Diabetes, Cardiovascular Risks, and LipoproteinsDiabetes Treatment and ManagementDiet, Metabolism, and Disease

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Effectiveness of interventions for reducing diabetes and cardiovascular disease risk in people with metabolic syndrome: Systematic review and mixed treatment comparison meta-analysis

Dunkley, A. J., Charles, K., Gray, L. J., Camosso‐Stefinovic, J., Davies, M. J., Khunti, K.·2012·Diabetes Obesity and Metabolism

DOI 10.1111/j.1463-1326.2012.01571.x

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Abstract

AIMS: To review the evidence on interventions for reversing metabolic syndrome or preventing development of type 2 diabetes and cardiovascular disease in people with metabolic syndrome. METHODS: A systematic review and Bayesian mixed treatment comparison meta-analysis was conducted. Relevant electronic bibliographic databases were searched up to January 2010. Included studies were randomized controlled trials with a follow-up of ≥24 weeks and outcomes comparing incidence of diabetes and/or cardiovascular disease, or reversal of metabolic syndrome. RESULTS: A total of 16 studies met the inclusion criteria. Thirteen studies with outcome data for reversal of metabolic syndrome, involving 3907 participants, were included in the meta-analysis. Insufficient trials reported cardiovascular events/mortality, or incidence of type 2 diabetes, to conduct a meta-analysis for these outcomes. Interventions, alone or in combination, included lifestyle (diet and/or exercise) and pharmacological therapy. Using random-effect models, both lifestyle (odds ratio, OR 3.81; 95% confidence interval, CI 2.47-5.88) and pharmacological interventions (OR 1.59; 95% CI 1.04-2.45) were statistically superior compared with control for reversing metabolic syndrome. Using mixed treatment comparison methods, the probability that lifestyle interventions were the most clinically effective was 87%. CONCLUSIONS: Evidence suggests that both lifestyle and pharmacological interventions can reverse metabolic syndrome. However, there is a lack of data on whether these benefits are sustained and translate into longer term prevention of diabetes and/or cardiovascular disease.

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Authors: Dunkley, A. J., Charles, K., Gray, L. J., Camosso‐Stefinovic, J., Davies, M. J., & Khunti, K.
Affiliations: University of Leicester (GB)
Corresponding author: Dunkley, A. J.
ORCID: Dunkley, A. J.
Gray, L. J.
Davies, M. J.
Khunti, K.
Venue: Diabetes Obesity and Metabolism
Publisher: Wiley
Published: 2012-02-21
Volume: 14
Issue: 7
Pages: 616-625
ISSN: 1462-8902 (ISSN-L)
1463-1326
DOI: 10.1111/j.1463-1326.2012.01571.x
OpenAlex: W2091832011
Cited by: 151
References: 46
Citations by year: 2026: 7 · 2025: 8 · 2024: 6 · 2023: 3 · 2022: 8 · 2021: 11 · 2020: 15 · 2019: 13 · 2018: 9 · 2017: 14 · 2016: 9 · 2015: 16 · 2014: 17 · 2013: 13 · 2012: 2
FWCI: 2.11
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Diabetes Obesity and Metabolism (publishedVersion)
PubMed (publishedVersion)
Leicester Research Archive (University of Leicester) (submittedVersion)
Funders: National Institute for Health and Care Research (RP-DG-1210-10183, RP-PG-0606-1272)
University of Leicester
National Institutes of Health
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Keywords: metabolic syndrome, type 2 diabetes prevention, cardiovascular disease prevention, lifestyle intervention, pharmacotherapy, diet, physical activity, diabetes risk
MeSH terms: Bayes Theorem, Cardiovascular Diseases, Diabetes Mellitus, Type 2, Female, Humans, Hypoglycemic Agents, Male, Prognosis, Exercise, Odds Ratio, Outcome Assessment, Health Care, Metabolic Syndrome, Risk Reduction Behavior

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Effectiveness of interventions for reducing diabetes and cardiovascular disease risk in people with metabolic syndrome: Systematic review and mixed treatment comparison meta-analysis

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