The DOI matches its Crossref record; 224 of the 224 references it cites were found in a registry or an index.
The molecular biology of chronic wounds and delayed healing in diabetes
Abstract
Wound healing is a complicated and integrated process. Although there is some tolerance in terms of redundancy and interrelated control mechanisms, pushing beyond such limits may contribute to delayed wound healing, and in extreme cases lead to chronic wounds/ulcers and thus potentially to lower extremity amputation. Diabetes is associated with such disruption in wound healing. Research in humans and in animal models has identified a large number of changes associated with diabetes at the molecular level in delayed wound healing and to a lesser extent in chronic diabetic ulcers. Better overall understanding of these changes and how they are interrelated would allow for specifically targeted treatment, thus ensuring improved quality of life for patients and providing savings to the high costs that are associated with all aspects of chronic diabetic ulcers. This review examines the work done at the molecular level on chronic diabetic ulcers, as well as considering changes seen in diabetes in general, both in humans and animal models, that may in turn contribute to ulcer formation.
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In the citing paper
“Diabetics typically suffer from delayed and diminished wound healing.127”
From Biocompatible Materials for Continuous Glucose Monitoring Devices (2013) · cites this paper as [127]
In the citing paper
“During impaired healing associated with diabetes, wounds exhibit prolonged accumulation of Mp associated with elevated levels of proinflammatory cytokines and proteases and reduced levels of various growth factors (2,12,13).”
From Sustained Inflammasome Activity in Macrophages Impairs Wound Healing in Type 2 Diabetic Humans and Mice (2014) · cites this paper as [2]
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Items 201–224 of 224
Craig, R. G., Zhao, Y., Xu, L., Barr, R., Ramamurthy, N., Boland, J., Schneir, M., & Golub, L. M. (1998) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(98)00008-1 · Cited by 39
Delivery of a Growth Factor Fusion Protein Having Collagen‐Binding Activity to Wound Tissues
Ishikawa, T., Terai, H., Yamamoto, T., Harada, K., & Kitajima, T. (2003) · Artificial Organs · doi:10.1046/j.1525-1594.2003.07009.x · Cited by 39
Duraisamy, Y., Gaffney, J., SLEVIN, M. A., Smith, C. A., Williamson, K., & Ahmed, N. (2003) · Molecular and Cellular Biochemistry · doi:10.1023/a:1023470921116 · Cited by 39
Sampson, M., ASTLEY, S. B., Richardson, T., Willis, G. A., Davies, I. R., Hughes, D. A., & Southon, S. (2001) · Clinical Science · doi:10.1042/cs1010235 · Cited by 38
Gelatinase Activities in Wounds of Healing-Impaired Mice Versus Wounds of Non-Healing-Impaired Mice
Neely, A. N., Clendening, C. E., Gardner, J., & Greenhalgh, D. G. (2000) · Journal of Burn Care & Rehabilitation · doi:10.1097/00004630-200021050-00001 · Cited by 38
Yoram Vodovotz, B., Letterio, J. J., Geiser, A. G., Chester, L., Roberts, A. B., & Sparrow, J. R. (1996) · Journal of Leukocyte Biology · doi:10.1002/jlb.60.2.261 · Cited by 37
The complement system in Type 1 (insulin-dependent) diabetes
CHARLESWORTH, J. A., Timmermans, V., Golding, J., Campbell, L. V., Peake, P. W., Pussell, B. A., Wakefield, D., & Howard, N. (1987) · Diabetologia · doi:10.1007/bf00292537 · Cited by 36
Cantürk, N. Z., Vural, B., Esen, N., Cantürk, Z., Oktay, G., Kırkalı, G., & Solakoğlu, S. (1999) · Endocrine Research · doi:10.3109/07435809909066133 · Cited by 36
Terasaki, K., Kanzaki, T., Aoki, T., Iwata, K., & Saiki, I. (2003) · The Journal of Dermatology · doi:10.1111/j.1346-8138.2003.tb00367.x · Cited by 35
IFN-α2b Suppresses the Fibrogenic Effects of Insulin-Like Growth Factor-1 in Dermal Fibroblasts
Telasky, C., Tredget, E. E., Shen, Q. “., Khorramizadeh, M. R., Iwashina, T., Scott, P. G., & Ghahary, A. (1998) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.1998.18.571 · Cited by 34
Possible Genetic Defects in Regulation of Glycosaminoglycans in Patients With Diabetic Nephropathy
Deckert, T., Horowitz, I. M., Kofoed‐Enevoldsen, A., Kjellén, L., Deckert, M., Lykkelund, C., & Burcharth, F. (1991) · Diabetes · doi:10.2337/diab.40.6.764 · Cited by 32
Bertheim, U., Engström‐Laurent, A., Hofer, P., Hällgren, P., Asplund, J., & Hellström, S. (2002) · Acta Dermato Venereologica · doi:10.1080/000155502320624041 · Cited by 30
Castronuovo, J., Ghobrial, I. I., Giusti, A., Rudolph, S., & Smiell, J. M. (1998) · The American Journal of Surgery · doi:10.1016/s0002-9610(98)00175-5 · Cited by 30
Cechowska‐Pasko, M., Palka, J. A., & Bańkowski, E. (1996) · Molecular and Cellular Biochemistry · doi:10.1007/bf00248454 · Cited by 30
Jude, E. B., Tentolouris, N., Appleton, I., Anderson, S. G., & Boulton, A. J. M. (2001) · Wound Repair and Regeneration · doi:10.1046/j.1524-475x.2001.00353.x · Cited by 29
Self-citationHasegawa, G., Hunter, A., & CHARONIS, A. S. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.7.3278 · Cited by 27
Wysocki, J., Wierusz‐Wysocka, B., Wykrętowicz, A., & Wysocki, H. (1992) · PubMed · Cited by 26
Koivukangas, V., Annala, A.-P., Salmela, P. I., & Oikarinen, A. (1999) · Diabetic Medicine · doi:10.1046/j.1464-5491.1999.00117.x · Cited by 25
Göhde, W., Cassens, U., Lehman, L. G., Traoré, Y., jun., W. G., Perkes, P., Westerberg, C., & Greve, B. (2003) · Transfusion Medicine and Hemotherapy · doi:10.1159/000073325 · Cited by 22
Polymerisation and crosslinking of fibrin monomers in diabetes mellitus
Lütjens, A., Jonkhoff-Slok, T. W., Sandkuijl, C., van der Veen, E. A., & Meer, J. V. D. (1988) · Diabetologia · doi:10.1007/bf00277485 · Cited by 22
Inactivation and loss of antigenicity of esterase by sugars and a steroid
YAN, H. H., & Harding, J. J. (1999) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/s0925-4439(99)00035-6 · Cited by 20
Nonenzymatic Glycation Alters Properties of Collagen as a Substratum for Cells
Kawano, E., Takahashi, S.-I., Sakano, Y., & Fujimoto, D. (1990) · Matrix · doi:10.1016/s0934-8832(11)80185-x · Cited by 16
TRANSFORMING GROWTH FACTOR-β PROMOTES FIBROBLAST APOPTOSIS INDUCED BY H 2 O 2
安田, 公., Aoshiba, K., & Nagai, A. (2003) · Experimental Lung Research · doi:10.1080/01902140303773 · Cited by 14
Decreased biosynthesis of glycosaminoglycans in the skin of rats with chronic diabetes mellitus
Cechowska‐Pasko, M., Palka, J. A., & Bańkowski, E. (1999) · Experimental and Toxicologic Pathology · doi:10.1016/s0940-2993(99)80105-5 · Cited by 14
Research works printed but not linked: 5
- Jude EB, 1999, End‐stage complications of diabetic neuropathy, Diabet Rev, 7, 395
- 10.1002/1520-7560(200009/10)16:1 <::AID-DMRR142>3.0.CO;2-S · DOI
- Wierusz‐Wysocka B, 1985, Phagocytosis, bactericidal capacity, and superoxide anion (02–) production by polymorphonuclear neutrophils from patients with diabetes mellitus, Folia Haematol Int Mag Klin Morph Blutforsch, 112, 658
- 10.1210/jc.74.6.1352 · DOI
- Williams DRR., 1994, The Foot in Diabetes, 15
Cited by
Sorted by citations
Krzyszczyk, P., Schloss, R. S., Palmer, A. F., & Francois Berthiaume, B. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00419 · Cited by 1,606
Inflammation in Chronic Wounds
Zhao, R., Liang, H. H., Clarke, E., Jackson, C., & Xue, M. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17122085 · Cited by 1,250
Pathogenesis and Treatment of Impaired Wound Healing in Diabetes Mellitus: New Insights
Baltzis, D., Eleftheriadou, I., & Veves, A. (2014) · Advances in Therapy · doi:10.1007/s12325-014-0140-x · Cited by 755
Curcumin as a wound healing agent
Akbik, D., Ghadiri, M., Chrzanowski, W., & Rohanizadeh, R. (2014) · Life Sciences · doi:10.1016/j.lfs.2014.08.016 · Cited by 745
Hu, L., Wang, J., Zhou, X., Xiong, Z., Zhao, J., Yu, R., Huang, F., Zhang, H., & Chen, L. (2016) · Scientific Reports · doi:10.1038/srep32993 · Cited by 693
Metadata
- Authors
- Blakytny, R., & Jude, E.
- Affiliations
- Fachklinik Hornheide (DE)
- Tameside Hospital (GB)
- Corresponding author
- Jude, E.
- ORCID
- Jude, E.
- Venue
- Diabetic Medicine
- Publisher
- Wiley
- Published
- 2006-02-13
- Volume
- 23
- Issue
- 6
- Pages
- 594-608
- ISSN
- 0742-3071 (ISSN-L)
- 1464-5491
- OpenAlex
- W1967162280
- Cited by
- 632
- References
- 224
- Citations by year
- 2026: 13 · 2025: 32 · 2024: 34 · 2023: 50 · 2022: 38 · 2021: 65 · 2020: 41 · 2019: 36 · 2018: 32 · 2017: 38 · 2016: 43 · 2015: 37 · 2014: 40 · 2013: 31 · 2012: 22
- FWCI
- 2.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetic Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetic Foot Ulcer Assessment and Management
- Health Sciences › Medicine › Dermatology › Skin Diseases and Diabetes
- Keywords
- chronic wounds, diabetic ulcers, delayed wound healing, diabetes mellitus, molecular mechanisms, lower limb amputation, animal models of diabetes
- MeSH terms
- Animals, Diabetes Mellitus, Experimental, Extracellular Matrix, Glucose, Humans, Nitric Oxide, Oxidation-Reduction, Skin, Wound Healing, Cytokines, Intercellular Signaling Peptides and Proteins, Diabetes Complications
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