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Cited by 189Thyroid Disorders and TreatmentsChronic Kidney Disease and DiabetesDiabetes, Cardiovascular Risks, and Lipoproteins

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

Subclinical hypothyroidism is a risk factor for nephropathy and cardiovascular diseases in type 2 diabetic patients.

Chen, H.‐S., Wu, T.‐E. J., Jap, T.‐S., Lu, R.‐A., Wang, M.‐L., Chen, R.‐L., Lin, H.‐D.·2007·Diabetic Medicine
DOI 10.1111/j.1464-5491.2007.02270.x
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Abstract

AIMS: The purpose of this study was to determine the relationship between subclinical hypothyroidism and prevalence of retinopathy and nephropathy, incident cardiovascular disease, and mortality in Type 2 diabetic patients without taking thyroid medication. METHODS: Serum thyrotropin and free thyroxine concentrations were measured in 588 Type 2 diabetic subjects in Taipei Veterans General Hospital, Taiwan. In a cross-sectional study, we examined the prevalence of retinopathy and nephropathy. In a longitudinal study, we examined the risk of cardiovascular disease events, cardiovascular mortality and total mortality in the 4-year follow-up. RESULTS: In the cross-sectional analysis, subclinical hypothyroidism was associated with a greater prevalence of diabetic nephropathy (odds ratio, 3.15 [95% CI, 1.48-6.69]) and did not show a high prevalence of diabetic retinopathy (odds ratio, 1.15 [95% CI, 0.59-2.26]) compare to euthyroid diabetics. During the 44.0 +/- 7.4 months of follow-up, 51 participants had cardiovascular events. The risk of cardiovascular events was significantly increased in Type 2 diabetics with subclinical hypothyroidism after adjustment for age, sex, A1C, other standard cardiovascular risk factors and medication (hazard ratio, 2.93; 95% CI, 1.15-7.48; P = 0.024), but it became nonsignificant after additional adjustment for urinary albumin-to-creatinine ratio (hazard ratio, 2.06; 95% CI, 0.67-6.36; P = 0.211). The rates of cardiovascular-related and total mortality did not significantly differ by thyroid status. CONCLUSIONS: Type 2 diabetic patients with subclinical hypothyroidism are associated with an increased risk of nephropathy and cardiovascular events, but not with retinopathy. Our data suggest that the higher cardiovascular events in subclinical hypothyroidism with Type 2 diabetes may be mediated with nephropathy.

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  1. 10.1210/jcem.87.2.8182 · DOI · Paper page

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Metadata

Authors
Chen, H. ‐., Wu, T. ‐. J., Jap, T. ‐., Lu, R. ‐., Wang, M. ‐., Chen, R. ‐., & Lin, H. ‐.
Affiliations
  • Taipei Veterans General Hospital (TW)
  • National Yang Ming University (TW)
ORCID
Chen, H.‐S.
Venue
Diabetic Medicine
Publisher
Wiley
Published
2007-11-26
Volume
24
Issue
12
Pages
1336-1344
ISSN
  • 0742-3071 (ISSN-L)
  • 1464-5491
DOI
10.1111/j.1464-5491.2007.02270.x
OpenAlex
W2052124893
Cited by
189
References
37
Citations by year
2026: 4 · 2025: 6 · 2024: 10 · 2023: 19 · 2022: 12 · 2021: 14 · 2020: 16 · 2019: 12 · 2018: 13 · 2017: 9 · 2016: 11 · 2015: 8 · 2014: 16 · 2013: 11 · 2012: 6
FWCI
3.65
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Diabetic Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
subclinical hypothyroidism, type 2 diabetes, diabetic nephropathy, diabetic retinopathy, cardiovascular disease, cardiovascular mortality, all-cause mortality, albumin-creatinine ratio, thyroid-stimulating hormone, free thyroxine, thyroid function
MeSH terms
Aged, Cardiovascular Diseases, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Diabetic Nephropathies, Diabetic Retinopathy, Female, Humans, Hypothyroidism, Male, Middle Aged, Risk Factors, Taiwan, Thyrotropin, Thyroxine, Cohort Studies, Incidence, Odds Ratio

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