Diabetes and Decline in Heart Disease Mortality in US Adults
Abstract
Context Mortality from coronary heart disease has declined substantially in the United States during the past 30 years. However, it is unknown whether patients with diabetes have also experienced a decline in heart disease mortality. Objective To compare adults with diabetes with those without diabetes for time trends in mortality from all causes, heart disease, and ischemic heart disease. Design, setting, and participants Representative cohorts of subjects with and without diabetes were derived from the First National Health and Nutrition Examination Survey (NHANES I) conducted between 1971 and 1975 (n = 9639) and the NHANES I Epidemiologic Follow-up Survey conducted between 1982 and 1984 (n = 8463). The cohorts were followed up prospectively for mortality for an average of 8 to 9 years. Main outcome measure Changes in mortality rates per 1000 person-years for all causes, heart disease, and ischemic heart disease for the 1982-1984 cohort compared with the 1971-1975 cohort. Results For the 2 periods, nondiabetic men experienced a 36.4% decline in age-adjusted heart disease mortality compared with a 13.1% decline for diabetic men. Age-adjusted heart disease mortality declined 27% in nondiabetic women but increased 23% in diabetic women. These patterns were also found for all-cause mortality and ischemic heart disease mortality. Conclusions The decline in heart disease mortality in the general US population has been attributed to reduction in cardiovascular risk factors and imp…
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Type 2 diabetes mellitus is associated with a high rate of complications related to cardiovascular disease and diabetic nephropathy, retinopathy, and neuropathy.
“T ype 2 diabetes mellitus is associated with a high rate of complications related to cardiovascular disease and diabetic nephropathy, retinopathy, and neuropathy.[1][2][3]”
From Effect of a multifactorial intervention on mortality in type 2 diabetes (2008) · cites this paper as [2]
The rate of death among patients with type 2 diabetes is approximately twice as high as that among persons without the disorder.
“The rate of death among patients with type 2 diabetes is approximately twice as high as that among persons without the disorder.2,3”
From Effect of a multifactorial intervention on mortality in type 2 diabetes (2008) · cites this paper as [2]
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“Follow-up was completed for 96% of subjects.(5) Two nationally representative cross-sectional samples of adults aged 35 to 74 years were created from these data.”
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- Authors
- Gu, K.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Gu, Ken
- ORCID
- Gu, Ken
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 1999-04-14
- Volume
- 281
- Issue
- 14
- Pages
- 1291
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W2075378374
- Cited by
- 856
- References
- 1
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 11 · 2023: 11 · 2022: 12 · 2021: 14 · 2020: 15 · 2019: 17 · 2018: 20 · 2017: 30 · 2016: 15 · 2015: 14 · 2014: 29 · 2013: 18 · 2012: 41
- FWCI
- 26.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- JAMA (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Epidemiology › Healthcare Systems and Public Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
- Keywords
- diabetes mellitus, heart disease mortality, ischemic heart disease, mortality trends, sex differences, cardiovascular risk factors, cardiovascular disease treatment, all-cause mortality
- MeSH terms
- Adult, Aged, Diabetes Mellitus, Female, Health Surveys, Heart Diseases, Humans, Male, Middle Aged, Mortality, United States, Age Distribution, Diabetes Complications
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