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Cited by 15Gestational Diabetes Research and ManagementDiabetes, Cardiovascular Risks, and LipoproteinsLipid metabolism and disorders

Non-esterified fatty acid dynamics during oral glucose tolerance test in women with former gestational diabetes

Tura, A., Pacini, G., Winhofer, Y., Bozkurt, L., Di Benedetto, G., Morbiducci, U., Roden, M., Kautzky‐Willer, A.·2012·Diabetic Medicine
DOI 10.1111/j.1464-5491.2011.03477.x
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Abstract

AIMS: Women with former gestational diabetes are at increased risk of Type 2 diabetes, which likely relates to hyperlipidaemia and ectopic lipid storage, mainly in the liver. Here, we examined the response of non-esterified fatty acid dynamics to oral glucose loading (oral glucose tolerance test). METHODS: We studied women with former gestational diabetes with normal glucose tolerance (n = 60) or impaired glucose metabolism (n = 12) and compared them with healthy women after normal pregnancy (control subjects, n = 15). During a 3-h oral glucose tolerance test, glucose, insulin and non-esterified fatty acid were frequently measured to compute the area under the non-esterified fatty acid curve and parameters of β-cell function and insulin sensitivity. Through mathematical modelling, we assessed insulin sensitivity of lipolysis inhibition and the fractional non-esterified fatty acid turnover rate. We also measured some serum liver enzymes. RESULTS: Women with former gestational diabetes were slightly older and had greater body mass than control subjects. Subjects with impaired glucose metabolism had lower oral glucose insulin sensitivity, but higher fasting insulin and area under the non-esterified fatty acid curve, which inversely related to oral glucose insulin sensitivity and independently determined mean glycaemia. Model-derived non-esterified fatty acid parameters were lower in subjects with impaired glucose metabolism than in control subjects, particularly sensitivity of non-esterified fatty acid inhibition to insulin (2.50 ± 0.52 vs. 1.06 ± 0.20 · 10(-2) ml/μU). Also, subjects with impaired glucose metabolism had higher liver transaminases. However, all non-esterified fatty acid parameters showed only modest inverse correlation with liver transaminases. CONCLUSIONS: Despite greater insulinaemia, circulating non-esterified fatty acids are higher in women with former gestational diabetes than in control subjects, which likely results from reduced sensitivity of lipolysis inhibition to insulin. This parameter may serve as indicator of an early metabolic derangement in this population at risk for diabetes.

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  • The concept of a compartment remote from plasma is not new in mathematical models of glucose metabolism, being used in the original Minimal Model and more recently in other models.

    “the concept of a compartment remote from plasma is not new in mathematical models of glucose metabolism, being used as an example in the well-known original Minimal Model (for the assessment of insulin sensitivity and glucose effectiveness from an IVGTT) (50), and more recently in other models, such as our model for the assessment of non-esterified fatty acids kinetics (51).”

    From Mathematical Model of Glucagon Kinetics for the Assessment of Insulin-Mediated Glucagon Inhibition During an Oral Glucose Tolerance Test (2021) · cites this paper as [51]

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Authors
Tura, A., Pacini, G., Winhofer, Y., Bozkurt, L., Di Benedetto, G., Morbiducci, U., Roden, M., & Kautzky‐Willer, A.
Affiliations
  • National Research Council (IT)
  • Medical University of Vienna (AT)
  • Politecnico di Torino (IT)
  • Deutsches Diabetes-Zentrum e.V. (DE)
Corresponding author
Tura, A.
ORCID
Venue
Diabetic Medicine
Publisher
Wiley
Published
2012-02-22
Volume
29
Issue
3
Pages
351-358
ISSN
  • 0742-3071 (ISSN-L)
  • 1464-5491
DOI
10.1111/j.1464-5491.2011.03477.x
OpenAlex
W2097845875
Cited by
15
References
23
Citations by year
2024: 2 · 2023: 1 · 2021: 1 · 2019: 3 · 2017: 1 · 2015: 2 · 2014: 2 · 2013: 3
FWCI
2.06
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Diabetic Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Keywords
free fatty acids, gestational diabetes mellitus, type 2 diabetes risk, oral glucose tolerance test, insulin sensitivity, lipolysis inhibition, impaired glucose tolerance, hepatic transaminases, hepatic lipid accumulation, hyperlipidemia, mathematical modeling
MeSH terms
Insulin Secretion, Adult, Diabetes Mellitus, Type 2, Fatty Acids, Nonesterified, Female, Glucose Tolerance Test, Humans, Insulin, Insulin Resistance, Liver, Pregnancy, Models, Statistical, Diabetes, Gestational, Insulin-Secreting Cells

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