The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
Plant‐made vaccines for humans and animals
Open accessAbstract
Summary: The concept of using plants to produce high‐value pharmaceuticals such as vaccines is 20 years old this year and is only now on the brink of realisation as an established technology. The original reliance on transgenic plants has largely given way to transient expression; proofs of concept for human and animal vaccines and of efficacy for animal vaccines have been established; several plant‐produced vaccines have been through Phase I clinical trials in humans and more are scheduled; regulatory requirements are more clear than ever, and more facilities exist for manufacture of clinic‐grade materials. The original concept of cheap edible vaccines has given way to a realisation that formulated products are required, which may well be injectable. The technology has proven its worth as a means of cheap, easily scalable production of materials: it now needs to find its niche in competition with established technologies. The realised achievements in the field as well as promising new developments will be reviewed, such as rapid‐response vaccines for emerging viruses with pandemic potential and bioterror agents.
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Cites
Pushko, P., Pumpens, P., & Grens, E. (2013) · Intervirology · doi:10.1159/000346773 · Cited by 5,950
Production of antibodies in transgenic plants
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Plant-based production of biopharmaceuticals
Fischer, R., Stoger, E., Schillberg, S., Christou, P., & Twyman, R. M. (2004) · Current Opinion in Plant Biology · doi:10.1016/j.pbi.2004.01.007 · Cited by 634
Oral Immunization with a Recombinant Bacterial Antigen Produced in Transgenic Plants
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Transgenic plants as factories for biopharmaceuticals
Giddings, G., Allison, G., Brooks, D., & Carter, A. (2000) · Nature Biotechnology · doi:10.1038/81132 · Cited by 582
Magnifection?a new platform for expressing recombinant vaccines in plants
GLEBA, Y., KLIMYUK, V, & MARILLONNET, S. (2005) · Vaccine · doi:10.1016/j.vaccine.2005.01.006 · Cited by 441
Viral vectors for the expression of proteins in plants
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Shaaltiel, Y., Bartfeld, D., Hashmueli, S., Baum, G., Brill‐Almon, E., Galili, G., Dym, O., Boldin‐Adamsky, S. A., Silman, I., Sussman, J. L., et al. (2007) · Plant Biotechnology Journal · doi:10.1111/j.1467-7652.2007.00263.x · Cited by 425
Plant‐specific glycosylation patterns in the context of therapeutic protein production
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Cited by
Advances in plant molecular farming
Obembe, O. O., Popoola, J. O., Leelavathi, S., & Reddy, S. V. (2011) · Biotechnology Advances · doi:10.1016/j.biotechadv.2010.11.004 · Cited by 276
A Review of UK-Registered and Candidate Vaccines for Bovine Respiratory Disease
Lemon, J. L., & McMenamy, M. J. (2021) · Vaccines · doi:10.3390/vaccines9121403 · Cited by 12
Metadata
- Authors
- Rybicki, E. P.
- Venue
- Plant Biotechnology Journal
- Publisher
- Wiley
- Published
- 2010-05-09
- Volume
- 8
- Issue
- 5
- Pages
- 620-637
- ISSN
- 1467-7644 (ISSN-L)
- 1467-7652
- OpenAlex
- W2149138353
- Cited by
- 334
- References
- 60
- FWCI
- 28.18
- Type
- journal article
- Language
- en
- Open access
- bronze
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
