Cited by 137Adipose Tissue and MetabolismMitochondrial Function and PathologyGenetic Associations and Epidemiology

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The polymorphisms of UCP2 and UCP3 genes associated with fat metabolism, obesity and diabetes

Jia, J.‐J., Zhang, X., Ge, C.‐R., Jois, M.·2009·Obesity Reviews

DOI 10.1111/j.1467-789x.2009.00569.x

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Abstract

Uncoupling proteins (UCPs) belong to the family of mitochondrial transporter proteins that may uncouple the transport of protons across the inner mitochondrial membrane from electron transport and the synthesis of ATP from ADP, hence generating heat rather than energy. In mammals, more than five family members have been identified, including UCP1, UCP2, UCP3, UCP4 (or BMCP1/UCP5) and UCP5. The UCPs may play an important role in energy homeostasis and have become prominent in the fields of thermogenesis, obesity, diabetes and free-radical biology and have been considered candidate genes for obesity and insulin resistance. They have been as important potential targets for treatment of aging, degenerative diseases, diabetes and obesity. Recently, a series of studies showed the polymorphisms of UCPs gene association with the fat metabolism, obesity and diabetes. This review summarizes data supporting the roles of UCP2 and UCP3 in energy dissipation, as well as the genetic variety association with fat metabolism, obesity and diabetes in humans.

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Obesity as a medical problem
Kopelman, P. G. (2000) · Nature · doi:10.1038/35007508 · Cited by 4,795
The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus
Weyer, C., Bogardus, C., Mott, D. M., & Pratley, R. E. (1999) · Journal of Clinical Investigation · doi:10.1172/jci7231 · Cited by 1,940
Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia
Fleury, C., Neverova, M., Collins, S., Raimbault, S., Champigny, O., Lévi-Meyrueis, C., Bouillaud, F., Seldin, M. F., Surwit, R. S., Ricquier, D., et al. (1997) · Nature Genetics · doi:10.1038/ng0397-269 · Cited by 1,630
The Human Obesity Gene Map: The 2005 Update
Rankinen, T., Zuberi, A., Chagnon, Y. C., Weisnagel, S. J., Argyropoulos, G., Walts, B., Pérusse, L., & Bouchard, C. (2006) · Obesity · doi:10.1038/oby.2006.71 · Cited by 1,119
Mitochondrial superoxide: production, biological effects, and activation of uncoupling proteins
Brand, M. D., Affourtit, C., Esteves, T. C., Green, K., Lambert, A. J., Miwa, S., Pakay, J. L., & Parker, N. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.05.034 · Cited by 1,032
Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, β-cell dysfunction, and type 2 diabetes.
Zhang, C.-Y., Baffy, G., Perret, P., Krauss, S., Peroni, O., Grujic, D., Hagen, T., Vidal-Puig, A. J., Boss, O., Kim, Y.-B., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00378-6 · Cited by 917
Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3
Brand, M. D., & Esteves, T. C. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.06.002 · Cited by 785
Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean
Clapham, J. C., Arch, J. R. S., Chapman, H., Haynes, A., Lister, C., Moore, G. B. T., Piercy, V., Carter, S. A., Lehner, I., Smith, S. A., et al. (2000) · Nature · doi:10.1038/35019082 · Cited by 604
A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans
Esterbauer, H., Schneitler, C., Oberkofler, H., Ebenbichler, C. F., Paulweber, B., Sandhofer, F., Ladurner, G., Hell, E., Strosberg, A. D., Patsch, J. R., et al. (2001) · Nature Genetics · doi:10.1038/88911 · Cited by 357
Association between uncoupling protein polymorphisms (UCP2-UCP3) and energy metabolism/obesity in Pima indians
Walder, K. R. (1998) · Human Molecular Genetics · doi:10.1093/hmg/7.9.1431 · Cited by 290
Invited Review: Uncoupling proteins and thermoregulation
Argyropoulos, G. A., & Harper, M. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00994.2001 · Cited by 258
Contribution of BAT and skeletal muscle to thermogenesis induced by ephedrine in man
Astrup, A. V., Bülow, J., Madsen, J., & Christensen, N. J. (1985) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1985.248.5.e507 · Cited by 241
Uncoupling proteins: functional characteristics and role in the pathogenesis of obesity and Type II diabetes
Dalgaard, L. T., & Pedersen, O. B. (2001) · Diabetologia · doi:10.1007/s001250100596 · Cited by 214
Uncoupling protein gene: quantification of expression levels in adipose tissues of obese and non-obese humans
Oberkofler, H., Dallinger, G., Liu, Y. M., Hell, E., Krempler, F., & Patsch, W. (1997) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37142-x · Cited by 194
DNA polymorphism in the uncoupling protein (UCP) gene and human body fat.
Oppert, J., Vohl, M., Chagnon, M., Dionne, F. T., Cassard, A., Ricquier, D., Përusse, L., & Bouchard, C. (1994) · PubMed · Cited by 185
A functional polymorphism in the promoter of UCP2 enhances obesity risk but reduces type 2 diabetes risk in obese middle-aged humans.
Krempler, F., Esterbauer, H., Weitgasser, R., Ebenbichler, C., Patsch, J., Miller, K., Xie, M., Linnemayr, V., Oberkofler, H., & Patsch, W. (2002) · Diabetes · doi:10.2337/diabetes.51.11.3331 · Cited by 178
The Human Uncoupling Protein-3 Gene
Solanes, G., Vidal‐Puig, A., Grujić, D., Flier, J. S., & Lowell, B. B. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.41.25433 · Cited by 172
Influences of genes and shared family environment on adult body mass index assessed in an adoption study by a comprehensive path model.
Vogler, G. P., Sørensen, T. I. A., Stunkard, A. J., Srinivasan, M. R., & Rao, D. C. (1995) · PubMed · Cited by 168
A genetic variation in the 5 ′ flanking region of the UCP3 gene is associated with body mass index in humans in interaction with physical activity
Otabe, S., Clément, K., Christian Dina, C., Pelloux, V., Guy-grand, B., Froguel, P., & Vasseur, F. (2000) · Diabetologia · doi:10.1007/s001250050037 · Cited by 161
Heritability of Pancreatic -Cell Function among Nondiabetic Members of Caucasian Familial Type 2 Diabetic Kindreds
Elbein, S. C., Hasstedt, S. J., Wegner, K., & Kahn, S. E. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.4.5604 · Cited by 154
Uncoupling protein-2 polymorphisms in type 2 diabetes, obesity, and insulin secretion
Wang, H., Chu, W. S., Lu, T., Hasstedt, S. J., Kern, P. A., & Elbein, S. C. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00231.2003 · Cited by 143
A Common Polymorphism in the Promoter of UCP2 Contributes to the Variation in Insulin Secretion in Glucose-Tolerant Subjects
Sesti, G., Cardellini, M., Marini, M. A., Frontoni, S., D’Adamo, M., Guerra, S. D., Lauro, D., de Nicolais, P., Sbraccia, P., Prato, S. D., et al. (2003) · Diabetes · doi:10.2337/diabetes.52.5.1280 · Cited by 131
The association between the val/ala-55 polymorphism of the uncoupling protein 2 gene and exercise efficiency
Buemann, B., Schierning, B., Toubro, S., Bibby, B. M., Sørensen, T. I. A., Dalgaard, L. T., Pedersen, O. B., & Astrup, A. V. (2001) · International Journal of Obesity · doi:10.1038/sj.ijo.0801564 · Cited by 130
A novel polymorphism in the proximal UCP3 promoter region: effect on skeletal muscle UCP3 mRNA expression and obesity in male non-diabetic Pima Indians
Schrauwen, P., Xia, J., Walder, K. R., Snitker, S., & Ravussin, É. (1999) · International Journal of Obesity · doi:10.1038/sj.ijo.0801057 · Cited by 117
Uncoupling Protein—A Useful Energy Dissepator
Klingenberg, M. (1999) · Journal of Bioenergetics and Biomembranes · doi:10.1023/a:1005440221914 · Cited by 116
Impact of the v/v 55 polymorphism of the uncoupling protein 2 gene on 24‐h energy expenditure and substrate oxidation
Astrup, A. V., Toubro, S., Dalgaard, L. T., Urhammer, S., Ti, S., & Pedersen, O. B. (1999) · International Journal of Obesity · doi:10.1038/sj.ijo.0801040 · Cited by 112
An uncoupling protein 2 gene variant is associated with a raised body mass index but not Type II diabetes
Cassell, P. G., Neverova, M., Janmohamed, S. G., Uwakwe, N., Qureshi, A., McCarthy, M. I., Saker, P. J., Albon, L., Kopelman, P., Noonan, K., et al. (1999) · Diabetologia · doi:10.1007/s001250051216 · Cited by 109
Racial differences in the relation between uncoupling protein genes and resting energy expenditure
Kimm, S. Y. S., Glynn, N. W., Aston, C. E., Damcott, C., Poehlman, É. T., Daniels, S. R., & Ferrell, R. E. (2002) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/75.4.714 · Cited by 105
Uncoupling Protein 2 Promoter Polymorphism −866G/A Affects Its Expression in β-Cells and Modulates Clinical Profiles of Japanese Type 2 Diabetic Patients
Sasahara, M., Nishi, M., Kawashima, H., Ueda, K., Sakagashira, S., Furuta, H., Matsumoto, E., Hanabusa, T., Sasaki, H., & Nanjo, K. (2004) · Diabetes · doi:10.2337/diabetes.53.2.482 · Cited by 101
The −866A/A Genotype in the Promoter of the Human Uncoupling Protein 2 Gene Is Associated With Insulin Resistance and Increased Risk of Type 2 Diabetes
D’Adamo, M., Perego, L., Cardellini, M., Marini, M. A., Frontoni, S., Andreozzi, F., Sciacqua, A., Lauro, D., Sbraccia, P., Federici, M., et al. (2004) · Diabetes · doi:10.2337/diabetes.53.7.1905 · Cited by 100
Uncoupling protein-2: evidence for its function as a metabolic regulator
Saleh, M. C., Wheeler, M. B., & Chan, C. B. (2002) · Diabetologia · doi:10.1007/s00125-001-0737-x · Cited by 99
The Role of Energy Expenditure in Energy Regulation: Findings from a Decade of Research
Saltzman, E., & Roberts, S. B. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.1995.tb01554.x · Cited by 94
Human Uncoupling Protein‐3 and Obesity: An Update
Hesselink, M. K. C., Mensink, M., & Schrauwen, P. (2003) · Obesity Research · doi:10.1038/oby.2003.192 · Cited by 85
The Common −866G/A Polymorphism in the Promoter Region of the UCP-2 Gene Is Associated with Reduced Risk of Type 2 Diabetes in Caucasians from Italy
Bulotta, A., Ludovico, O., Coco, A., Paola, R. D., Quattrone, A., Carella, M., Pellegrini, F., Prudente, S., & Trischitta, V. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1072 · Cited by 79
An uncoupling protein 3 gene polymorphism associated with a lower risk of developing Type II diabetes and with atherogenic lipid profile in a French cohort
Meirhaeghe, A., Amouyel, P., Helbecque, N., Cottel, D., Otabe, S., Froguel, P., & Vasseur, F. (2000) · Diabetologia · doi:10.1007/s001250051549 · Cited by 76
Variation in the UCP2-UCP3 Gene Cluster Predicts the Development of Type 2 Diabetes in Healthy Middle-Aged Men
Gable, D. R., Stephens, J. W., Cooper, J. A., Miller, G. J., & Humphries, S. E. (2006) · Diabetes · doi:10.2337/db05-1645 · Cited by 74
Association of a common polymorphism in the promoter of UCP2 with susceptibility to multiple sclerosis
Vogler, S., Goedde, R., Miterski, B., Gold, R., Kroner, A., Koczan, D., Zettl, U. K., Rieckmann, P., Epplen, J. T., & Ibrahim, S. M. (2005) · Journal of Molecular Medicine · doi:10.1007/s00109-005-0661-5 · Cited by 72
Fat tissue accumulation during peritoneal dialysis is associated with a polymorphism in uncoupling protein 2
Nordfors, L., Heimbürger, O., Lönnqvist, F., Lindholm, B., Helmrich, J., Schalling, M., & Stenvinkel, P. (2000) · Kidney International · doi:10.1046/j.1523-1755.2000.00016.x · Cited by 72
Frequency of and interaction between polymorphisms in the β3-adrenergic receptor and in uncoupling proteins 1 and 2 and obesity in Germans
Evans, D., Minouchehr, S., Hagemann, G., Mann, W., Wendt, D., Wolf, A. M., & Beisiegel†, U. (2000) · International Journal of Obesity · doi:10.1038/sj.ijo.0801402 · Cited by 71
Sex and age specific assessment of genetic and environmental influences on body mass index in twins.
Herskind, A. M., McGue, M., Sørensen, T. I. A., & Harvald, B. (1996) · PubMed · Cited by 69
Functional Polymorphisms of UCP2 and UCP3 Are Associated With a Reduced Prevalence of Diabetic Neuropathy in Patients With Type 1 Diabetes
Rudofsky, G., Schroedter, A., Schlotterer, A., Voronko, O. E., Schlimme, M., Tafel, J., Isermann, B., Humpert, P. M., Morcos, M., Bierhaus, A., et al. (2006) · Diabetes Care · doi:10.2337/diacare.29.01.06.dc05-0757 · Cited by 68
Association between obesity and insulin resistance with UCP2–UCP3 gene variants in Spanish children and adolescents
Ochoa, M. C., Santos, J. L., Azcona, C., Moreno-Aliaga, M. J., Martínez‐González, M. Á., Martínez, J. A., & Martí, A. (2007) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2007.07.011 · Cited by 66
Uncoupling protein 3 genetic variants in human obesity: the c-55t promoter polymorphism is negatively correlated with body mass index in a UK Caucasian population
Halsall, D., Luan, J., Saker, P. J., Huxtable, S. J., Farooqi, I. S., Keogh, J. M., Wareham, N. J., & O’Rahilly, S. (2001) · International Journal of Obesity · doi:10.1038/sj.ijo.0801584 · Cited by 66
Ala55Val Polymorphism on UCP2 Gene Predicts Greater Weight Loss in Morbidly Obese Patients Undergoing Gastric Banding
Chen, H., Lee, W., Wang, W., Huang, M., Lee, Y.-C., & Pan, W. (2007) · Obesity Surgery · doi:10.1007/s11695-007-9171-6 · Cited by 60
Uncoupling protein 1 and 3 polymorphisms are associated with waist-to-hip ratio
Herrmann, S.-M., Wang, J., Staessen, J. A., Kertmen, E., Schmidt‐Petersen, K., Zidek, W., Paul, M., & Brand, E. (2003) · Journal of Molecular Medicine · doi:10.1007/s00109-003-0431-1 · Cited by 59
Linkage and association analyses of the UCP3 gene with obesity phenotypes in Caucasian families
Liu, Y., Liu, P.-Y., Long, J., Lü, Y., Elze, L., Recker, R. R., & Deng, H. (2005) · Physiological Genomics · doi:10.1152/physiolgenomics.00031.2005 · Cited by 59
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Fur, S. L., Stunff, C. L., Santos, C. D., & Bougneres, P. F. (2004) · Diabetes · doi:10.2337/diabetes.53.1.235 · Cited by 59
Mutational Analysis of the UCP2 Core Promoter and Relationships of Variants with Obesity
Dalgaard, L. T., Andersen, G., Larsen, L. H., Sørensen, T. I. A., Andersen, T., Drivsholm, T., Borch‐Johnsen, K., Fleckner, J., Hansen, T. F., Din, N., et al. (2003) · Obesity Research · doi:10.1038/oby.2003.191 · Cited by 54
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Shen, H., Qi, L., Tai, E. S., Chew, S. K., Tan, C. E., & Ordovás, J. M. (2006) · Obesity · doi:10.1038/oby.2006.74 · Cited by 47
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Cheurfa, N., Dubois‐Laforgue, D., Ferrarezi, D. A. F., Reis, A. F., Brenner, G. M., Bouché, C., Feuvre, C. L., Fumeron, F., Timsit, J., Marre, M., et al. (2008) · Diabetes · doi:10.2337/db07-1292 · Cited by 47
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Berentzen, T. L., Dalgaard, L. T., Petersen, L. V., Pedersen, O. B., & Sørensen, T. I. A. (2004) · International Journal of Obesity · doi:10.1038/sj.ijo.0802841 · Cited by 46
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Yoon, Y., Park, B. L., Ho, M., Kim, K. S., Cheong, H. S., Choi, Y. H., & Shin, H. D. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.05.110 · Cited by 46
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Yu, X., Jacobs, D. R., Schreiner, P. J., Gross, M. D., Steffes, M. W., & Fornage, M. (2005) · Clinical Chemistry · doi:10.1373/clinchem.2004.044859 · Cited by 46
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Association of UCP3 Gene –55C>T Polymorphism and Obesity in a Spanish Population
Alonso, Á., Martí, A., Corbalán, M. S., Martínez‐González, M. Á., Forga, L., & Martínez, J. A. (2005) · Annals of Nutrition and Metabolism · doi:10.1159/000086883 · Cited by 42
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Reis, A. F., Dubois‐Laforgue, D., Bellanné‐Chantelot, C., Timsit, J., & Velho, G. (2004) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2004.06.008 · Cited by 41
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Hsu, Y., Niu, T., Song, Y., Tinker, L. F., Kuller, L. H., & Liu, S. (2008) · Diabetes · doi:10.2337/db07-1269 · Cited by 40
Association of the ins/del polymorphisms of uncoupling protein 2 (UCP2) with BMI in a Korean population
Lee, Y. H., Kim, W. B., Yu, B. C., Park, B. L., Kim, L. H., & Shin, H. D. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.04.144 · Cited by 37
Role of UCP2 and UCP3 in nutrition and obesity
Nagy, T. R., Blaylock, M. L., & Garvey, W. T. (2003) · Nutrition · doi:10.1016/j.nut.2003.09.024 · Cited by 35
Changes in fat mass after initiation of maintenance dialysis is influenced by the uncoupling protein 2 exon 8 insertion/deletion polymorphism
Wang, X., Axelsson, J., Nordfors, L., Qureshi, A. R., Avesani, C. M., Barany, P. F., Schalling, M., Heimbürger, O., Lindholm, B., & Stenvinkel, P. (2006) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfl504 · Cited by 34
The common −55 C/T polymorphism in the promoter region of the uncoupling protein 3 gene reduces prevalence of obesity and elevates serum high-density lipoprotein cholesterol levels in the general Japanese population
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Yamasaki, H., Sasaki, H., Ogawa, K., Shono, T., Tamura, S., Doi, A., Sasahara, M., Kawashima, H., Nakao, T., Furuta, H., et al. (2006) · Diabetes Care · doi:10.2337/diacare.29.04.06.dc05-1984 · Cited by 30
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Authors: Jia, J. ‐., Zhang, X., Ge, C. ‐., & Jois, M.
Affiliations: Yunnan Agricultural University (CN)
La Trobe University (AU)
ORCID: Jia, J.‐J.
Jois, M.
Venue: Obesity Reviews
Publisher: Wiley
Published: 2009-08-26
Volume: 10
Issue: 5
Pages: 519-526
ISSN: 1467-7881 (ISSN-L)
1467-789X
DOI: 10.1111/j.1467-789x.2009.00569.x
OpenAlex: W2159844679
Cited by: 137
References: 67
Citations by year: 2026: 1 · 2025: 7 · 2024: 4 · 2023: 9 · 2022: 8 · 2021: 6 · 2020: 10 · 2019: 9 · 2018: 12 · 2017: 5 · 2016: 4 · 2015: 12 · 2014: 14 · 2013: 10 · 2012: 7
FWCI: 0.95
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Obesity Reviews (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords: uncoupling proteins, UCP2, UCP3, genetic polymorphism, fat metabolism, obesity, diabetes mellitus, insulin resistance, energy homeostasis, thermogenesis, mitochondrial uncoupling, genetic association
MeSH terms: Uncoupling Protein 2, Uncoupling Protein 3, Diabetes Mellitus, Exons, Haplotypes, Humans, Ion Channels, Obesity, Promoter Regions, Genetic, 3' Untranslated Regions, Polymorphism, Single Nucleotide, Mitochondrial Proteins, Lipid Metabolism, INDEL Mutation

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The polymorphisms of UCP2 and UCP3 genes associated with fat metabolism, obesity and diabetes

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