The DOI matches its Crossref record; 138 of the 138 references it cites were found in a registry or an index.
The renin‐angiotensin system: a link between obesity, inflammation and insulin resistance
Abstract
Summary: The renin‐angiotensin system (RAS) is classically known for its role in regulation of blood pressure, fluid and electrolyte balance. Recently, several local RASs in organs such as brain, heart, pancreas and adipose tissue have also been identified. Evidence from clinical trials suggests that in addition to anti‐hypertensive effects, pharmacological inhibition of RAS also provides protection against the development of type‐2 diabetes. Moreover, animal models with targeted inactivation of RAS genes exhibit improved insulin sensitivity and are protected from high‐fat diet‐induced obesity and insulin resistance. Because there is evidence for RAS overactivation in obesity, it is possible that RAS is a link between obesity and insulin resistance. This review summarizes the evidence and mechanistic insights on the associations between RAS, obesity and insulin resistance, with special emphasis on the role of adipose tissue RAS in the pathogenesis of metabolic derangements in obesity.
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Cites
Inflammation and insulin resistance
Shoelson, S. E. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29069 · Cited by 4,769
Macrophages, inflammation, and insulin resistance
Olefsky, J. M., & Glass, C. K. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135846 · Cited by 2,733
Type 2 diabetes: principles of pathogenesis and therapy
Stumvoll, M., Goldstein, B. J., & van Haeften, T. W. (2005) · The Lancet · doi:10.1016/s0140-6736(05)61032-x · Cited by 2,662
Nishimura, S., Manabe, I., Nagasaki, M., Eto, K., Yamashita, H., Ohsugi, M., Otsu, M., Hara, K., Ueki, K., Sugiura, S., et al. (2009) · Nature Medicine · doi:10.1038/nm.1964 · Cited by 2,230
Hansson, L., Lindholm, L. H., Niskanen, L., Lanke, J., Hedner, T., Niklason, A., Luomanmäki, K., Dahlöf, B., de Faire, U., Mörlin, C., et al. (1999) · The Lancet · doi:10.1016/s0140-6736(98)05012-0 · Cited by 2,014
Angiotensin-(1–7) is an endogenous ligand for the G protein-coupled receptor Mas
Santos, R. A. S., e Silva, A. C. S., Maric, C., Silva, D. M. R., Machado, R. P., de Buhr, I., Heringer-Walther, S., Pinheiro, S. V. B., Lopes, M. T., Bader, M., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1432869100 · Cited by 1,801
Physiology of Local Renin-Angiotensin Systems
Paul, M., Poyan Mehr, A., & Kreutz, R. (2006) · Physiological Reviews · doi:10.1152/physrev.00036.2005 · Cited by 1,739
Nguyen, G., Delarue, F., Burcklé, C., Bouzhir-Sima, L., Giller, T., & Sraer, J. (2002) · Journal of Clinical Investigation · doi:10.1172/jci14276 · Cited by 1,276
Insulin sensitivity: Modulation by nutrients and inflammation
Schenk, S., Saberi, M., & Olefsky, J. M. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34260 · Cited by 1,191
Nguyen, G., Delarue, F., Burcklé, C., Bouzhir, L., Giller, T., & Sraer, J.-D. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0214276 · Cited by 1,137
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Skeletal muscle insulin resistance: role of mitochondria and other ROS sources
Di Meo, S., Iossa, S., & Venditti, P. (2017) · Journal of Endocrinology · doi:10.1530/joe-16-0598 · Cited by 282
Obesity and Cardiac Remodeling in Adults: Mechanisms and Clinical Implications
Alpert, M. A., Karthikeyan, K., Abdullah, O., & Ghadban, R. (2018) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2018.07.012 · Cited by 221
Siriwardhana, N., Kalupahana, N. S., Fletcher, S., Xin, W., Claycombe, K. J., Quignard-Boulange, A., Zhao, L., Saxton, A. M., & Moustaid-Moussa, N. (2012) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2011.11.009 · Cited by 89
Renin–angiotensin system: Basic and clinical aspects—A general perspective
Vargas Vargas, R. A., Varela Millán, J. M., & Fajardo Bonilla, E. (2022) · Endocrinología, Diabetes y Nutrición (English ed.) · doi:10.1016/j.endien.2022.01.005 · Cited by 51
The Influence of Psychological Stress on the Initiation and Progression of Diabetes and Cancer
Afrisham, R., Paknejad, M., Soliemanifar, O., Sadegh-Nejadi, S., Meshkani, R., & Ashtary-Larky, D. (2019) · International Journal of Endocrinology and Metabolism · doi:10.5812/ijem.67400 · Cited by 44
Metadata
- Authors
- Kalupahana, N. S., & Moustaid‐Moussa, N.
- Venue
- Obesity Reviews
- Publisher
- Wiley
- Published
- 2011-10-31
- Volume
- 13
- Issue
- 2
- Pages
- 136-149
- ISSN
- 1467-7881 (ISSN-L)
- 1467-789X
- OpenAlex
- W1897553699
- Cited by
- 276
- References
- 138
- FWCI
- 13.74
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kalupahana, N. S., & Moustaid‐Moussa, N. (2012). The renin‐angiotensin system: a link between obesity, inflammation and insulin resistance. Obesity Reviews. https://doi.org/10.1111/j.1467-789x.2011.00942.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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