Cited by 44Cancer, Stress, Anesthesia, and Immune ResponseStress Responses and CortisolAdipokines, Inflammation, and Metabolic Diseases

The Influence of Psychological Stress on the Initiation and Progression of Diabetes and Cancer

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Afrisham, Reza, Paknejad, Maliheh, Soliemanifar, Omid, Sadegh-Nejadi, Sahar, Meshkani, Reza, Ashtary-Larky, Damoon·2019·International Journal of Endocrinology and Metabolism

Abstract

CONTEXT: Psychological stress can be considered a risk factor for the initiation and progression of many pathological conditions, including type 1 and 2 diabetes mellitus and cancer. OBJECTIVES: The aim of this review article was to evaluate the molecular and cellular mechanisms linking psychological stress to the onset and progression of diabetes and cancer. EVIDENCE ACQUISITION: The current review was conducted to survey and analyze studies related to the effects of psychological stress on diabetes and cancer. RESULTS: Psychological stress may make individuals prone to the development of diabetes through the impairment of the hypothalamic-pituitary-adrenal (HPA) axis function, sympathetic nerves system (SNS), lipid profile, cytokines balance, renin-angiotensin system (RAS), and insulin signaling pathway. Additionally, psychological stress can contribute to the development of cancer through the perturbation in the HPA axis, SNS function, and cytokines balance. Psychological stress is also capable of decreasing the levels of oxytocin and dopamine, leading to an increased risk of cancer in susceptible individuals. CONCLUSIONS: It seems that psychological stress plays a significant role in the onset and progression of diabetes and cancer. The identification of the pathways triggered by psychological stress would open up a new avenue for the understanding of molecular mechanisms by which diabetes and cancer could be managed or even prevented.

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Authors
Afrisham, R., Paknejad, M., Soliemanifar, O., Sadegh-Nejadi, S., Meshkani, R., & Ashtary-Larky, D.
Affiliations
Tehran University of Medical Sciences (IR)
Corresponding author
Afrisham, Reza
Venue
International Journal of Endocrinology and Metabolism
Publisher
Brieflands
Published
2019-04-20
Volume
In Press
Issue
In Press
Pages
e67400-e67400
ISSN
  • 1726-913X (ISSN-L)
  • 1726-9148
OpenAlex
W2936309685
Cited by
44
References
75
Citations by year
2026: 2 · 2025: 3 · 2024: 5 · 2023: 5 · 2022: 8 · 2021: 10 · 2020: 7 · 2019: 4
FWCI
1.22
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • Intern J Endocrinol Metab (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Cancer, Stress, Anesthesia, and Immune Response
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords
psychological stress, type 1 diabetes, type 2 diabetes, tumor progression, hypothalamic-pituitary-adrenal axis, sympathetic nervous system, cytokines, renin-angiotensin system, insulin signaling pathway, oxytocin, dopamine, lipid profile, stress as risk factor

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