The Influence of Psychological Stress on the Initiation and Progression of Diabetes and Cancer
Open accessAbstract
CONTEXT: Psychological stress can be considered a risk factor for the initiation and progression of many pathological conditions, including type 1 and 2 diabetes mellitus and cancer. OBJECTIVES: The aim of this review article was to evaluate the molecular and cellular mechanisms linking psychological stress to the onset and progression of diabetes and cancer. EVIDENCE ACQUISITION: The current review was conducted to survey and analyze studies related to the effects of psychological stress on diabetes and cancer. RESULTS: Psychological stress may make individuals prone to the development of diabetes through the impairment of the hypothalamic-pituitary-adrenal (HPA) axis function, sympathetic nerves system (SNS), lipid profile, cytokines balance, renin-angiotensin system (RAS), and insulin signaling pathway. Additionally, psychological stress can contribute to the development of cancer through the perturbation in the HPA axis, SNS function, and cytokines balance. Psychological stress is also capable of decreasing the levels of oxytocin and dopamine, leading to an increased risk of cancer in susceptible individuals. CONCLUSIONS: It seems that psychological stress plays a significant role in the onset and progression of diabetes and cancer. The identification of the pathways triggered by psychological stress would open up a new avenue for the understanding of molecular mechanisms by which diabetes and cancer could be managed or even prevented.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Stress is associated with an increased risk of rheumatoid arthritis, cardiovascular disease, cancer, and autoimmune diseases such as systemic lupus erythematosus, type 1 diabetes, and multiple sclerosis.
“Studies have found that stress was associated with an increased risk of rheumatoid arthritis [29], cardiovascular disease [30], cancer [31], and autoimmune diseases such as systemic lupus erythematosus, type 1 diabetes, and multiple sclerosis [32].”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Orimo, A., Gupta, P. B., Sgroi, D. C., Arenzana-Seisdedos, F., Delaunay, T., Naeem, R., Carey, V. J., Richardson, A. L., & Weinberg, R. A. (2005) · Cell · doi:10.1016/j.cell.2005.02.034 · Cited by 3,759 · see citing works
Type 2 diabetes as an inflammatory disease
Donath, M. Y., & Shoelson, S. E. (2011) · Nature Reviews Immunology · doi:10.1038/nri2925 · Cited by 3,737 · see citing works
Psychological Stress and Disease
Cohen, S., Janicki-Deverts, D., & Miller, G. E. (2007) · JAMA · doi:10.1001/jama.298.14.1685 · Cited by 3,168 · see citing works
Tumour necrosis factor and cancer
Balkwill, F. R. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2628 · Cited by 1,925 · see citing works
Inflammation and Activated Innate Immunity in the Pathogenesis of Type 2 Diabetes
Pickup, J. C. (2004) · Diabetes Care · doi:10.2337/diacare.27.3.813 · Cited by 1,414 · see citing works
Antiinflammatory Properties of HDL
Barter, P. J., Nicholls, S., Rye, K.-A., Anantharamaiah, G. M., Navab, M., & Fogelman, A. M. (2004) · Circulation Research · doi:10.1161/01.res.0000146094.59640.13 · Cited by 1,394 · see citing works
Diagnosis and complications of Cushing’s syndrome: a consensus statement
Arnaldi, G., Angeli, A., Atkinson, A. B., Bertagna, X., Cavagnini, F., Chrousos, G. P., Fava, G. A., Findling, J. W., Gaillard, R. C., Grossman, A. B., et al. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030871 · Cited by 1,362 · see citing works
Boden, G., & Shulman, G. I. (2002) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.32.s3.3.x · Cited by 1,300 · see citing works
Incident diabetes in clinical trials of antihypertensive drugs: a network meta-analysis
Elliott, W. J., & Meyer, P. M. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60108-1 · Cited by 1,016 · see citing works
The influence of bio-behavioural factors on tumour biology: pathways and mechanisms
Antoni, M. H., Lutgendorf, S. K., Cole, S. W., Dhabhar, F. S., Sephton, S. E., McDonald, P. G., Stefanek, M., & Sood, A. K. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1820 · Cited by 981 · see citing works
Stress hormone-mediated invasion of ovarian cancer cells
Sood, A. K., Bhatty, R., Kamat, A. A., Landen, C. N., Han, L., Thaker, P. H., Li, Y., Gershenson, D. M., Lutgendorf, S., & Cole, S. W. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-1698 · Cited by 491 · see citing works
The global implications of diabetes and cancer
Shi, Y., & Hu, F. B. (2014) · The Lancet · doi:10.1016/s0140-6736(14)60886-2 · Cited by 426 · see citing works
A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1
Hara, M. R., Kovacs, J. J., Whalen, E. J., Rajagopal, S., Strachan, R. T., Grant, W., Towers, A. J., Williams, B., Lam, C. M., Xiao, K., et al. (2011) · Nature · doi:10.1038/nature10368 · Cited by 420 · see citing works
HEALTH PSYCHOLOGY: Mapping Biobehavioral Contributions to Health and Illness
Baum, A., & Posluszny, D. M. (1999) · Annual Review of Psychology · doi:10.1146/annurev.psych.50.1.137 · Cited by 413 · cited 1× · see citing works
“In other words, stress can affect the ability of the human body to resist to pathological conditions (17).”
BackgroundStress and Immune Responses After Surgical Treatment for Regional Breast Cancer
Andersen, B. L., Farrar, W. B., Golden‐Kreutz, D. M., Kutz, L. A., MacCallum, R. C., Courtney, M. E., & Glaser, R. (1998) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/90.1.30 · Cited by 399 · see citing works
Basu, S., Nagy, J. A., Pal, S., Vasile, E., Eckelhoefer, I. A., Bliss, V. S., Manseau, E. J., Dasgupta, P., Dvorak, H. F., & Mukhopadhyay, D. (2001) · Nature Medicine · doi:10.1038/87895 · Cited by 396 · see citing works
Interleukin-6 in Bone Metastasis and Cancer Progression
Ara, T., & DeClerck, Y. (2010) · European Journal of Cancer · doi:10.1016/j.ejca.2010.02.026 · Cited by 395 · see citing works
Commuting the death sentence: how oocytes strive to survive
Tilly, J. L. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35099086 · Cited by 392 · see citing works
Zhao, W., & Townsend, M. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2008.10.014 · Cited by 353 · see citing works
Alpha1-adrenergic receptors: new insights and directions.
Piascik, M. T., & Perez, D. M. (2001) · PubMed · Cited by 329 · see citing works
Allen, L. F., Lefkowitz, R. J., Caron, M. G., & Cotecchia, S. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.24.11354 · Cited by 322 · see citing works
Norepinephrine-induced migration of SW 480 colon carcinoma cells is inhibited by beta-blockers.
Masur, K., Niggemann, B., Zänker, K. S., & Entschladen, F. (2001) · PubMed · Cited by 308 · see citing works
Szabó, S., Taché, Y., & Somogyi, A. (2012) · Stress · doi:10.3109/10253890.2012.710919 · Cited by 301 · see citing works
Wu, D. W., Katz, A. A., Lee, C., & Simon, M. I. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)35680-1 · Cited by 295 · see citing works
Adrenergic modulation of focal adhesion kinase protects human ovarian cancer cells from anoikis
Sood, A. K., Armaiz-Pena, G. N., Halder, J., Nick, A. M., Stone, R. L., Hu, W., Carroll, A. R., Spannuth, W. A., Deavers, M. T., Allen, J. K., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci40802 · Cited by 283 · see citing works
Black, P. H. (2006) · Medical Hypotheses · doi:10.1016/j.mehy.2006.04.008 · Cited by 276 · see citing works
The renin‐angiotensin system: a link between obesity, inflammation and insulin resistance
Kalupahana, N. S., & Moustaïd‐Moussa, N. (2011) · Obesity Reviews · doi:10.1111/j.1467-789x.2011.00942.x · Cited by 275 · see citing works
Effects of psychological stress on male fertility
Nargund, V. H. (2015) · Nature Reviews Urology · doi:10.1038/nrurol.2015.112 · Cited by 248 · see citing works
Src activation by β-adrenoreceptors is a key switch for tumour metastasis
Armaiz-Pena, G. N., Allen, J. K., Cruz, A., Stone, R. L., Nick, A. M., Lin, Y. G., Han, L. Y., Mangala, L. S., Villares, G. J., Vivas-Mejia, P., et al. (2013) · Nature Communications · doi:10.1038/ncomms2413 · Cited by 212 · see citing works
Depressive Symptoms and Change in Abdominal Obesity in Older Persons
Vogelzangs, N., Kritchevsky, S. B., Beekman, A. T. F., Newman, A. B., Satterfield, S., Simonsick, E. M., Yaffe, K., Harris, T. B., & Penninx, B. W. J. H. (2008) · Archives of General Psychiatry · doi:10.1001/archpsyc.65.12.1386 · Cited by 200 · see citing works
Eng, J. W. ‐., Kokolus, K. M., Reed, C. B., Hylander, B. L., Ma, W. W., & Repasky, E. A. (2014) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-014-1617-9 · Cited by 189 · see citing works
Renin-Angiotensin System and Angiotensin Receptor Blockers in the Metabolic Syndrome
Prasad, A., & Quyyumi, A. A. (2004) · Circulation · doi:10.1161/01.cir.0000141736.76561.78 · Cited by 178 · see citing works
Wu, W., Pew, T., Zou, M., Pang, D., & Conzen, S. D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m411200200 · Cited by 177 · see citing works
Duxbury, M. S., Ito, H., Zinner, M. J., Ashley, S. W., & Whang, E. E. (2004) · Surgery · doi:10.1016/j.surg.2003.10.017 · Cited by 162 · see citing works
Nilsson, M. B., Armaiz-Peña, G. N., Takahashi, R., Lin, Y. G., Trevino, J. G., Li, Y., Jennings, N., Arevalo, J. M. G., Lutgendorf, S. K., Gallick, G. E., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611539200 · Cited by 158 · see citing works
The β2-adrenergic receptor and Her2 comprise a positive feedback loop in human breast cancer cells
Shi, M., Liu, D., Duan, H., Lu, Q., Wang, L., Niu, L., Zhang, H., Yong, Z., Gong, Z., Song, L., et al. (2010) · Breast Cancer Research and Treatment · doi:10.1007/s10549-010-0822-2 · Cited by 127 · see citing works
Psychological Stress May Induce Diabetes-Related Autoimmunity in Infancy
Sepa, A., Wahlberg, J., Vaarala, O., FRODI, A. M., & Ludvigsson, J. (2005) · Diabetes Care · doi:10.2337/diacare.28.2.290 · Cited by 112 · see citing works
Molecular Mechanisms Underlying Psychological Stress and Cancer
Shin, K. J., Lee, Y. J., Yang, Y. R., Park, S., Suh, P., Follo, M. Y., Cocco, L., & Ryu, S. H. (2016) · Current Pharmaceutical Design · doi:10.2174/1381612822666160226144025 · Cited by 111 · see citing works
Hoeppner, L. H., Wang, Y., Sharma, A. K., Javeed, N., Keulen, V. P. V., Wang, E., Yang, P., Roden, A. C., Peikert, T., Molina, J. R., et al. (2014) · Molecular Oncology · doi:10.1016/j.molonc.2014.08.008 · Cited by 100 · see citing works
Metabolic syndrome: what is it and what are the implications?
Shaw, D. I., Hall, W. L., & Williams, C. M. (2005) · Proceedings of The Nutrition Society · doi:10.1079/pns2005442 · Cited by 96 · see citing works
Nagaraja, A. S., Dorniak, P. L., Sadaoui, N. C., Kang, Y., Lin, T., Armaiz-Peña, G. N., Wu, S. Y., Rupaimoole, R., Allen, J. K., Gharpure, K. M., et al. (2015) · Oncogene · doi:10.1038/onc.2015.302 · Cited by 95 · see citing works
Pan, W., Li, P., Guo, Z., Huang, Q., & Gao, Y. (2015) · Pediatric Blood & Cancer · doi:10.1002/pbc.25453 · Cited by 94 · see citing works
Stress Augments Insulin Resistance and Prothrombotic State
Uchida, Y., Takeshita, K., Yamamoto, K., Kikuchi, R., Nakayama, T., Nomura, M., Cheng, X. W., Egashira, K., Matsushita, T., Nakamura, H., et al. (2012) · Diabetes · doi:10.2337/db11-0828 · Cited by 90 · see citing works
α2‐Adrenoceptor action on cell proliferation and mammary tumour growth in mice
Bruzzone, A., Piñero, C. P., Castillo, L. F., Sarappa, M. G., Rojas, P. A., Lanari, C., & Lüthy, I. A. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.278 · Cited by 89 · see citing works
Adrenergic signaling promotes angiogenesis through endothelial cell-tumor cell crosstalk
Chen, H., Liu, D., Yang, Z., Sun, L., Deng, Q., Yang, S., Qian, L., Guo, L., Yu, M., Hu, M., et al. (2014) · Endocrine Related Cancer · doi:10.1530/erc-14-0236 · Cited by 88 · see citing works
Kimura, K., Yamada, T., Matsumoto, M., Kido, Y., Hosooka, T., Asahara, S., Matsuda, T., Ota, T., Watanabe, H., Sai, Y., et al. (2011) · Diabetes · doi:10.2337/db10-1684 · Cited by 88 · see citing works
Relationship between Personality and Biological Reactivity to Stress: A Review
Soliemanifar, O., Soleymanifar, A., & Afrisham, R. (2018) · Psychiatry Investigation · doi:10.30773/pi.2018.10.14.2 · Cited by 80 · see citing works
Self-citationMattacks, C. A., & Pond, C. M. (1999) · Cytokine · doi:10.1006/cyto.1998.0442 · Cited by 79 · see citing works
Nowotny, B., Cavka, M., Herder, C., Löffler, H., Poschen, U., Joksimovic, L., Kempf, K., Krug, A. W., Koenig, W., Martin, S., et al. (2010) · Hormone and Metabolic Research · doi:10.1055/s-0030-1261924 · Cited by 77 · see citing works
Dopamine and serotonin regulate tumor behavior by affecting angiogenesis
Peters, M. A. M., Walenkamp, A., Kema, I. P., Meijer, C., de Vries, E. G. E., & Oosting, S. F. (2014) · Drug Resistance Updates · doi:10.1016/j.drup.2014.09.001 · Cited by 77 · see citing works
Acute mental stress impairs insulin sensitivity in IDDM patients
Moberg, E., Kollind, M., Lins, P. E., & Adamson, U. (1994) · Diabetologia · doi:10.1007/bf00398050 · Cited by 71 · see citing works
Groeschel, M., & Braam, B. G. (2010) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00208.2010 · Cited by 69 · see citing works
Stress resilience and subsequent risk of type 2 diabetes in 1.5 million young men
Crump, C., Sundquist, J., Winkleby, M. A., & Sundquist, K. (2016) · Diabetologia · doi:10.1007/s00125-015-3846-7 · Cited by 65 · see citing works
Vallés, S. L., Benlloch, M., Rodríguez, M. L., Mena, S., Pellicer, J. A., Asensi, M. A., Obrador, E., & Estrela, J. M. (2013) · Journal of Translational Medicine · doi:10.1186/1479-5876-11-72 · Cited by 64 · see citing works
Huang, J., Zhang, Y.-L., Wang, C.-C., Zhou, J., Ma, Q., Wang, X., Shen, X.-H., & Jiang, C. (2011) · Inflammation · doi:10.1007/s10753-011-9342-4 · Cited by 63 · see citing works
Human breast cell lines exhibit functional α2-adrenoceptors
Vázquez, S. M., Mladovan, A., Piñero, C. P., Bruzzone, A., Baldi, A., & Lüthy, I. A. (2005) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-005-0130-4 · Cited by 63 · see citing works
Abundance and stability of complexes containing inactive G protein‐coupled receptors and G proteins
Qin, K., Sethi, P. R., & Lambert, N. A. (2008) · The FASEB Journal · doi:10.1096/fj.08-105775 · Cited by 60 · see citing works
Postprandial hyperglycaemic state: importance and consequences.
Lebovitz, H. E. (1998) · PubMed · Cited by 59 · see citing works
Neutel, J. M. (2004) · Journal of Human Hypertension · doi:10.1038/sj.jhh.1001714 · Cited by 58 · see citing works
Karavanaki, K., Tsoka, E., Liacopoulou, M., Karayianni, C., Petrou, V., Pippidou, E., Brisimitzi, M., Mavrikiou, M., Kakleas, K., & Dacou‐Voutetakis, C. (2008) · Journal of Endocrinological Investigation · doi:10.1007/bf03346384 · Cited by 54 · see citing works
Factors Associated with Caregiver Burden in Dementia: 1-Year Follow-Up Study
Shim, S., Kang, H. S., Kim, J. H., & Kim, D. K. (2016) · Psychiatry Investigation · doi:10.4306/pi.2016.13.1.43 · Cited by 53 · see citing works
Green, P. G., Jänig, W., & Levine, J. D. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-09-03234.1997 · Cited by 51 · see citing works
Okazaki, M., Hu, Z., Fujinaga, M., & Hoffman, B. B. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117309 · Cited by 50 · see citing works
Bruzzone, A., Piñero, C. P., Rojas, P. A., Romanato, M., Gass, H., Lanari, C., & Lüthy, I. A. (2011) · Current Cancer Drug Targets · doi:10.2174/156800911796191051 · Cited by 46 · see citing works
Afrisham, R., Sadegh‐Nejadi, S., Soliemanifar, O., Kooti, W., Ashtary‐Larky, D., Alamiri, F., Aberomand, M., Najjar-Asl, S., & Khanehkeshi, A. (2016) · Psychiatry Investigation · doi:10.4306/pi.2016.13.6.637 · Cited by 39 · see citing works
Self-citationHayashi, M., Takeshita, K., Uchida, Y., Yamamoto, K., Kikuchi, R., Nakayama, T., Nomura, E., Cheng, X. W., Matsushita, T., Nakamura, S., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0116163 · Cited by 36 · see citing works
The “Father of Stress” Meets “Big Tobacco”: Hans Selye and the Tobacco Industry
Petticrew, M. P., & Lee, K. (2010) · American Journal of Public Health · doi:10.2105/ajph.2009.177634 · Cited by 35 · see citing works
Norepinephrine Stimulates Mobilization of Endothelial Progenitor Cells after Limb Ischemia
Jiang, Q., Ding, S., Wu, J., Liu, X., & Wu, Z. (2014) · PLoS ONE · doi:10.1371/journal.pone.0101774 · Cited by 32 · see citing works
Adhesion barriers for abdominal surgery: a sticky problem
Trochsler, M., & Maddern, G. J. (2013) · The Lancet · doi:10.1016/s0140-6736(13)62002-4 · Cited by 31 · see citing works
Neurohumoral stimulation in type-2-diabetes as an emerging disease concept
Pliquett, R., Faßhauer, M., Blüher, M., & Paschke, R. (2004) · Cardiovascular Diabetology · doi:10.1186/1475-2840-3-4 · Cited by 25 · see citing works
Decrease in frequency of cerebral palsy in preterm infants
Hack, M., & Costello, D. W. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60006-3 · Cited by 24 · see citing works
Media and Stress in Adolescent Boys in Germany
Maass, A., Lohaus, A., & Wolf, O. T. (2010) · Journal of Children and Media · doi:10.1080/17482790903407259 · Cited by 17 · see citing works
Afrisham, R., Aberomand, M., Soliemanifar, O., Kooti, W., Ashtary‐Larky, D., Alamiri, F., Najjar-Asl, S., Khanehkeshi, A., & Sadegh‐Nejadi, S. (2016) · Scientific Electronic library online (Sciences Carlos III Health Institute) · Cited by 17 · see citing works
Self-citationSadegh‐Nejadi, S., Afrisham, R., Soliemanifar, O., Kooti, W., Aberomand, M., Najjar-Asl, S., & Khanehkeshi, A. (2017) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 5 · see citing works
Self-citationRuparel, R. K., Mount, L. E., Jayaram, P., & Viswanath, S. (2008) · The FASEB Journal · doi:10.1096/fasebj.22.2_supplement.7 · Cited by 3 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Diamond, L. M., & Alley, J. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104720 · Cited by 412 · see citing works
Risk Factors for the Diagnosis of Colorectal Cancer
Lewandowska, A., Rudzki, G., Lewandowski, T., Stryjkowska-Góra, A., & Rudzki, S. (2022) · Cancer Control · doi:10.1177/10732748211056692 · Cited by 276 · see citing works
The Rise of Gastrointestinal Cancers as a Global Phenomenon: Unhealthy Behavior or Progress?
Jardim, S. R., de Souza, L. M. P., & de Souza, H. S. P. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20043640 · Cited by 149 · see citing works
Psychological Stress and Cellular Aging in Cancer: A Meta-Analysis
Kruk, J., Aboul-Enein, B. H., Bernstein, J., & Gronostaj, M. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/1270397 · Cited by 137 · see citing works
Chronic Stress and Diabetes Mellitus: Interwoven Pathologies
Sharma, V. K., & Singh, T. G. (2020) · Current Diabetes Reviews · doi:10.2174/1573399815666191111152248 · Cited by 116 · see citing works
Mechanisms Underlying the Comorbidity of Schizophrenia and Type 2 Diabetes Mellitus
Mizuki, Y., Sakamoto, S., Okahisa, Y., Yada, Y., Hashimoto, N., Takaki, M., & Yamada, N. (2020) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyaa097 · Cited by 83 · see citing works
Asbaghi, O., Ashtary‐Larky, D., Bagheri, R., Moosavian, S. P., Olyaei, H. P., Nazarian, B., Kelishadi, M. R., Wong, A., Candow, D. G., Dutheil, F., et al. (2021) · Nutrients · doi:10.3390/nu13072355 · Cited by 74 · see citing works
Self-citationChronic Stress, Inflammation, and Colon Cancer: A CRH System-Driven Molecular Crosstalk
Baritaki, S., de Bree, E., Chatzaki, Ε., & Pothoulakis, C. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8101669 · Cited by 67 · see citing works
Werdermann, M., Berger, I., Scriba, L. D., Santambrogio, A., Schlinkert, P., Brendel, H., Morawietz, H., Schedl, A., Peitzsch, M., King, A., et al. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101112 · Cited by 49 · see citing works
Animal Models for Functional Gastrointestinal Disorders
Accarie, A., & Vanuytsel, T. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.509681 · Cited by 48 · see citing works
Hu, Y., Wang, W.-R., Ma, W., Wang, W., Ren, W., Wang, S., Fu, F., & Li, Y. (2024) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2024.5475 · Cited by 52 · see citing works
Zheng, Y., Zhang, J., Huang, W., Zhong, L. L. D., Wang, N., Wang, S., Yang, B., Wang, X., Pan, B., Situ, H., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.714163 · Cited by 38 · see citing works
Asbaghi, O., Naeini, F., Ashtary‐Larky, D., Moradi, S., Zakeri, N., Eslampour, E., Kelishadi, M. R., & Naeini, A. A. (2021) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2021.126741 · Cited by 36 · see citing works
Self-citationInfluence of Psychological Factors in Breast and Lung Cancer Risk – A Systematic Review
Pereira, M. A., Araújo, A., Simões, M., & da Costa, C. J. M. (2022) · Frontiers in Psychology · doi:10.3389/fpsyg.2021.769394 · Cited by 34 · see citing works
Jetelina, K. K., Carr, C. L., Murphy, C. C., Sadeghi, N., Lea, J. S., & Tiro, J. A. (2020) · Journal of Cancer Survivorship · doi:10.1007/s11764-020-00902-x · Cited by 27 · see citing works
Srisurapanont, M., Suttajit, S., Kosachunhanun, N., Likhitsathian, S., Suradom, C., & Maneeton, B. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104731 · Cited by 27 · see citing works
Kautzky, A., Heneis, K., Stengg, K., Fröhlich, S., & Kautzky‐Willer, A. (2021) · Neuroendocrinology · doi:10.1159/000514484 · Cited by 24 · see citing works
Stress and the Gut-Brain Axis: Implications for Cancer, Inflammation and Sepsis
Moughnyeh, M., Brawner, K. M., Kennedy, B. A., Yeramilli, V. A., Udayakumar, N., Graham, J. A., & Martin, C. A. (2021) · Journal of Surgical Research · doi:10.1016/j.jss.2021.02.055 · Cited by 22 · see citing works
Effect of stress on sleep hygiene among school going adolescents in Chennai
Ramamoorthy, S., Dilara, K., Ravichandran, L., & Sundaramahalingam, M. (2019) · Journal of Family Medicine and Primary Care · doi:10.4103/jfmpc.jfmpc_564_19 · Cited by 22 · see citing works
Khademian, F., Aslani, A., Ravangard, R., Bastani, P., Nami, M., & Jafari, P. (2020) · Trials · doi:10.1186/s13063-020-04949-0 · Cited by 20 · see citing works
Can Yogic Breathing Techniques Like Simha Kriya and Isha Kriya Regulate COVID-19-Related Stress?
Rain, M., Subramaniam, B., Avti, P., Mahajan, P., & Anand, A. (2021) · Frontiers in Psychology · doi:10.3389/fpsyg.2021.635816 · Cited by 12 · see citing works
Extracellular Vesicles: Potential Mediators of Psychosocial Stress Contribution to Osteoporosis?
He, Y., Wuertz‐Kozak, K., Kuehl, L. K., & Wippert, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115846 · Cited by 22 · see citing works
Meoded, M. D., Tănase, M., Mehedințu, C., & Cirimbei, C. (2025) · Medicina · doi:10.3390/medicina61061008 · Cited by 15 · see citing works
Németh, Z., Kiss, É., & Takács, I. (2022) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2709253 · Cited by 12 · see citing works
Decoding TGR5: A comprehensive review of its impact on cerebral diseases
Zhang, Z., Zhang, Y., Peng, H., Yu, Q., Kang, X., Liu, Y., Zheng, Y., Cheng, F., Wang, X., & Li, F. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107671 · Cited by 10 · see citing works
Sensitivity of the Neuroendocrine Stress Axis in Metabolic Diseases
Cozma, D., Siatra, P., Bornstein, S. R., & Steenblock, C. (2024) · Hormone and Metabolic Research · doi:10.1055/a-2201-6641 · Cited by 9 · see citing works
Naz, M. S. G., Sheidaei, A., Azizi, F., & Tehrani, F. R. (2022) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2022.108311 · Cited by 5 · see citing works
Akbulut, S., Küçükakçalı, Z., Sarıtaş, H., Bozkır, Ç., Tamer, M., Akyuz, M., BAĞCI, N., Ünsal, S., Akbulut, M. S., Şahin, T. T., et al. (2023) · Diagnostics · doi:10.3390/diagnostics13081410 · Cited by 4 · see citing works
Mohamed, A. A., & Alawna, M. (2021) · World Journal of Clinical Cases · doi:10.12998/wjcc.v9.i19.4939 · Cited by 4 · see citing works
Jokanović, B., Vrgović, P., Ćulibrk, J., Tomić, I., & Jošanov-Vrgović, I. (2025) · Sustainability · doi:10.3390/su17177843 · Cited by 3 · see citing works
Guo, J., Wang, H., Zou, X., Huang, R., Liang, Z., & Liang, S. (2024) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-024-07497-z · Cited by 3 · see citing works
Economic Recession and the Risk of Cancer: A Cohort Study From Eastern Finland
Jarroch, R., Tajik, B., Tuomainen, T., & Kauhanen, J. (2021) · Journal of Epidemiology · doi:10.2188/jea.je20200595 · Cited by 3 · see citing works
Nguyen, A. P.-U., Angosta, A. D., Ke, W., Khong, T. M., Tran, C. C., & Kim, M. T. (2022) · The Science of Diabetes Self-Management and Care · doi:10.1177/26350106221116902 · Cited by 2 · see citing works
Wevers, A., Román-Mata, S. S., Ledesma, S. N., & Pruimboom, L. (2024) · Biomedicines · doi:10.3390/biomedicines12112539 · Cited by 2 · see citing works
[A Review of Chronic Stress and the Initiation and Evolution of Cancer].
Liu, M., Xie, X., Li, Q., & Xu, C. S. (2021) · PubMed Central · doi:10.12182/20210160203 · Cited by 2 · see citing works
Just-Nørregaard, V., Dalgaard, V. L., Bruun, J. M., Jh, A., & Winding, T. N. (2026) · Scientific Reports · doi:10.1038/s41598-026-35066-8 · Cited by 1 · see citing works
Diabetes mellitus as a result of neuroimmunoendocrine disorders
Samotruyeva, M. A., Сергалиева, М. У., Цибизова, А. А., & Akhadova, D. A. (2020) · Человек и его здоровье · doi:10.21626/vestnik/2020-2/08 · Cited by 1 · see citing works
Pirnia, B., Hamdieh, M., Ashtiani, M. K., Malekanmehr, P., Pirnia, K., Zahiroddin, A., & Sadeghi, P. (2020) · PubMed Central · doi:10.22037/ijpr.2020.14338.12314 · Cited by 1 · see citing works
Role of stress management in oral malignant and premalignant conditions
Dagli, N., Thangavelu, L. P., Dagli, R., & Ezhilarasan, D. (2022) · Oral Oncology · doi:10.1016/j.oraloncology.2022.105813 · Cited by 1 · see citing works
ПСИХОЛОГІЧНИЙ СТАН У ЖІНОК З ГІПЕРПРОЛІФЕРАТИВНИМИ ПРОЦЕСАМИ ЕНДОМЕТРІЮ ТА МЕТАБОЛІЧНИМ СИНДРОМОМ
Щербина, М. О., & Полякова, Є. (2023) · Перспективи та інновації науки · doi:10.52058/2786-4952-2023-12(30)-1092-1103
Rahim, A. R., Anggoro, J., & Priyambodo, S. (2023) · Unram Medical Journal · doi:10.29303/jku.v12i2.912
Rahim, A. R., Anggoro, J., & Priyambodo, S. (2023) · Unram Medical Journal · doi:10.29303/jk.v12i2.4353
Stress Classification Model Using Speech: An Ambulatory Protocol-Based Database Study
Prado, L. E., Hongn, A., Pelle, P. A., & Bonomini, M. P. (2024) · Lecture notes in computer science · doi:10.1007/978-3-031-61140-7_24
Tumor associated depression, gut microbiota, and immune checkpoint inhibitor sensitivity
Wang, J. (2026) · Psycho-Oncologie · doi:10.18282/po5751
- Authors
- Afrisham, R., Paknejad, M., Soliemanifar, O., Sadegh-Nejadi, S., Meshkani, R., & Ashtary-Larky, D.
- Affiliations
- Tehran University of Medical Sciences (IR)
- Corresponding author
- Afrisham, Reza
- Venue
- International Journal of Endocrinology and Metabolism
- Publisher
- Brieflands
- Published
- 2019-04-20
- Volume
- In Press
- Issue
- In Press
- Pages
- e67400-e67400
- ISSN
- 1726-913X (ISSN-L)
- 1726-9148
- PMC
- PMC6628619
- OpenAlex
- W2936309685
- Cited by
- 44
- References
- 75
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 5 · 2023: 5 · 2022: 8 · 2021: 10 · 2020: 7 · 2019: 4
- FWCI
- 1.22
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc
- Locations
- Intern J Endocrinol Metab (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Cancer, Stress, Anesthesia, and Immune Response
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- psychological stress, type 1 diabetes, type 2 diabetes, tumor progression, hypothalamic-pituitary-adrenal axis, sympathetic nervous system, cytokines, renin-angiotensin system, insulin signaling pathway, oxytocin, dopamine, lipid profile, stress as risk factor
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review