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Cited by 221Cardiovascular Function and Risk FactorsCardiac Fibrosis and RemodelingCardiovascular Disease and Adiposity

Obesity and Cardiac Remodeling in Adults: Mechanisms and Clinical Implications

Alpert, Martin A., Karthikeyan, Kamalesh, Abdullah, Obai, Ghadban, Rugheed·2018·Progress in Cardiovascular Diseases
DOI 10.1016/j.pcad.2018.07.012
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Abstract

Obesity, particularly severe obesity is capable of producing hemodynamic alterations that contribute to changes in cardiac morphology which may predispose to impairment of ventricular function and heart failure. These include a high cardiac output state in most, left ventricular (LV) hypertrophy, and LV diastolic dysfunction. Right heart involvement may result from LV failure, the hypercirculatory state, and sleep disordered breathing. In recent years experimental studies and some studies in humans suggest that certain neurohormonal and metabolic alterations that occur commonly in obesity may contribute to alterations in cardiac structure and function. These include activation of the renin-angiotensin-aldosterone and sympathetic nervous systems, hyperleptinemia due to leptin resistance, low circulating adiponectin levels, insulin resistance with hyperinsulinemia, and possibly cardiac lipotoxicity. This review will describe the ways in which these factors weave together to promote adaptations and maladaptations that result in alterations in cardiac structure and function which may contribute to the development of heart failure.

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Crossref · 10.1016/j.pcad.2018.07.012

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141 of 141 references verified0 citation errors · 0 not checkable

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  • Enlargement of the atria occurs in obesity and is related, in part, to volume expansion, increased venous return and cardiac preload.

    “Enlargement of the atria also occurs in obesity and is related, in part, to volume expansion, increased venous return and cardiac preload36.”

    From Obesity, kidney dysfunction and hypertension: mechanistic links (2019) · cites this paper as [36]

  • Excessive weight gain increases heart rate and cardiac output in experimental animals and in humans.

    “Excessive weight gain increases heart rate (HR) and cardiac output (CO) in experimental animals and in humans35,36 (TABLE 1).”

    From Obesity, kidney dysfunction and hypertension: mechanistic links (2019) · cites this paper as [36]

  • Obesity is associated with eccentric and concentric left ventricular hypertrophy.

    “Thus, obesity is associated with eccentric and concentric LVH36,41.”

    From Obesity, kidney dysfunction and hypertension: mechanistic links (2019) · cites this paper as [36]

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Authors
Alpert, M. A., Karthikeyan, K., Abdullah, O., & Ghadban, R.
Affiliations
University of Missouri (US)
Corresponding author
Alpert, Martin A.
ORCID
Venue
Progress in Cardiovascular Diseases
Publisher
Elsevier BV
Published
2018-07
Volume
61
Issue
2
Pages
114-123
ISSN
0033-0620 (ISSN-L)
DOI
10.1016/j.pcad.2018.07.012
OpenAlex
W2853743497
Cited by
221
References
142
Citations by year
2026: 18 · 2025: 36 · 2024: 25 · 2023: 19 · 2022: 34 · 2021: 29 · 2020: 36 · 2019: 17 · 2018: 6 · 2012: 1
FWCI
4.10
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Progress in Cardiovascular Diseases (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Keywords
obesity, cardiac remodeling, heart failure, left ventricular hypertrophy, diastolic dysfunction, right heart failure, sleep-disordered breathing, renin-angiotensin-aldosterone system, sympathetic activation, leptin resistance, hyperleptinemia, adiponectin, insulin resistance, hyperinsulinemia, cardiac lipotoxicity
MeSH terms
Animals, Cardiovascular Diseases, Energy Metabolism, Heart, Hemodynamics, Humans, Myocardium, Obesity, Prognosis, Risk Factors, Weight Loss, Ventricular Function, Left, Ventricular Function, Right, Neurotransmitter Agents, Ventricular Remodeling

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