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Cited by 318Diet and metabolism studiesDietary Effects on HealthNutritional Studies and Diet

The DOI matches its Crossref record; 75 of the 75 references it cites were found in a registry or an index.

Systematic review and meta‐analysis of clinical trials of the effects of low carbohydrate diets on cardiovascular risk factors

Santos, F. L., Esteves, S. S., da Costa Pereira, A., Yancy Jr, W. S., Nunes, J. P. L.·2012·Obesity Reviews
DOI 10.1111/j.1467-789x.2012.01021.x
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Abstract

Summary: A systematic review and meta‐analysis were carried out to study the effects of low‐carbohydrate diet (LCD) on weight loss and cardiovascular risk factors (search performed on PubMed, Cochrane Central Register of Controlled Trials and Scopus databases). A total of 23 reports, corresponding to 17 clinical investigations, were identified as meeting the pre‐specified criteria. Meta‐analysis carried out on data obtained in 1,141 obese patients, showed the LCD to be associated with significant decreases in body weight (−7.04 kg [95% CI −7.20/−6.88]), body mass index (−2.09 kg m−2[95% CI −2.15/−2.04]), abdominal circumference (−5.74 cm [95% CI −6.07/−5.41]), systolic blood pressure (−4.81 mm Hg [95% CI −5.33/−4.29]), diastolic blood pressure (−3.10 mm Hg [95% CI −3.45/−2.74]), plasma triglycerides (−29.71 mg dL−1[95% CI −31.99/−27.44]), fasting plasma glucose (−1.05 mg dL−1[95% CI −1.67/−0.44]), glycated haemoglobin (−0.21% [95% CI −0.24/−0.18]), plasma insulin (−2.24 micro IU mL−1[95% CI −2.65/−1.82]) and plasma C‐reactive protein, as well as an increase in high‐density lipoprotein cholesterol (1.73 mg dL−1[95%CI 1.44/2.01]). Low‐density lipoprotein cholesterol and creatinine did not change significantly, whereas limited data exist concerning plasma uric acid. LCD was shown to have favourable effects on body weight and major cardiovascular risk factors; however the effects on long‐term health are unknown.

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Research works printed but not linked: 2

  1. Atkins RC, 2002, Dr. Atkins New Diet Revolution (Revised Edition)
  2. Confucius, 1979, Analects

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Metadata

Authors
Santos, F. L., Esteves, S. S., da Costa Pereira, A., Yancy Jr, W. S., & Nunes, J. P. L.
Affiliations
  • Centro Hospitalar de Vila Nova de Gaia (PT)
  • Centro Hospitalar do Porto (PT)
  • Universidade do Porto (PT)
Corresponding author
Nunes, J. P. L.
ORCID
Venue
Obesity Reviews
Publisher
Wiley
Published
2012-08-21
Volume
13
Issue
11
Pages
1048-1066
ISSN
  • 1467-7881 (ISSN-L)
  • 1467-789X
DOI
10.1111/j.1467-789x.2012.01021.x
OpenAlex
W2110483590
Cited by
318
References
75
Citations by year
2026: 10 · 2025: 20 · 2024: 24 · 2023: 25 · 2022: 16 · 2021: 29 · 2020: 34 · 2019: 16 · 2018: 28 · 2017: 19 · 2016: 25 · 2015: 26 · 2014: 21 · 2013: 23 · 2012: 1
FWCI
2.48
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Obesity Reviews (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology (medical) › Diet and metabolism studies
  • Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords
low-carbohydrate diet, cardiovascular risk factors, weight loss, obesity, blood pressure, triglycerides, fasting blood glucose, HbA1c, insulin, C-reactive protein, HDL cholesterol, LDL cholesterol, uric acid, abdominal circumference
MeSH terms
Blood Glucose, Blood Pressure, Cardiovascular Diseases, Cholesterol, Dietary Carbohydrates, Humans, Insulin, Risk Factors, Triglycerides, Weight Loss, Randomized Controlled Trials as Topic, Treatment Outcome, Diet, Carbohydrate-Restricted

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