The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Expression of clock genes Per1 and Bmal1 in total leukocytes in health and Parkinson’s disease
Abstract
BACKGROUND: There is a growing number of clinical studies that revealed a variety of behavioral and physiological desynchronies in patients with Parkinson's disease (PD). However, these desynchronies have not been defined at the molecular level. METHODS: Using real-time RT-PCR assay, we analyzed the expression profiles of two principle clock genes, PER1 and BMAL1, in total leukocytes for 12 h during the evening, overnight and morning in subjects with PD and age/sex-matched healthy controls. RESULTS: A difference in the expression pattern of BMAL1 but not PER1 was apparent during the dark span, where the relative abundance of BMAL1 was significantly lower in PD patients versus control subjects at 21:00, 00:00 and 06:00 h. Furthermore, expression levels of BMAL1 in PD patients correlated with their United Parkinson's Disease Rating Scale score at 06:00, 09:00 h, and with Pittsburgh Sleep Quality Index score at 06:00 h. CONCLUSION: These results suggest that a peripheral molecular clock, as reflected in the dampened expression of the clock genes BMAL1 in total leukocytes, is altered in PD patients. In addition, the relative BMAL1 levels correlate positively with PD severity, which could provide a molecular basis to help monitor disease progression and response to investigational drugs.
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“Expression levels of Bmal1 patients correlated with PD severity as assessed by the Unified Parkinson Disease Rating Scale (UPDRS) (Cai et al., 2010).”
From Circadian dysregulation in Parkinson's disease (2017) · cites this paper as Cai et al., 2010
In the citing paper
“Among 17 individuals with PD and 16 age-matched controls, the relative abundance of the clock gene Bmal1 was significantly lower during the night in PD patients.”
From Circadian dysregulation in Parkinson's disease (2017) · cites this paper as Cai et al., 2010
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Metadata
- Authors
- Cai, Y., Liu, S., Sothern, R. B., Xu, S., & Chan, P.
- Affiliations
- Capital Medical University (CN)
- University of Minnesota (US)
- Corresponding author
- Xu, S.
- Chan, P.
- Venue
- European Journal of Neurology
- Publisher
- Wiley
- Published
- 2010-03-15
- Volume
- 17
- Issue
- 4
- Pages
- 550-554
- ISSN
- 1351-5101 (ISSN-L)
- 1468-1331
- OpenAlex
- W1969022395
- Cited by
- 184
- References
- 28
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 12 · 2023: 24 · 2022: 15 · 2021: 15 · 2020: 17 · 2019: 7 · 2018: 15 · 2017: 13 · 2016: 9 · 2015: 7 · 2014: 8 · 2013: 7 · 2012: 7
- FWCI
- 2.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- Parkinson's disease, clock genes, Per1, Bmal1, circadian rhythm, leukocytes, circadian gene expression, disease severity, sleep quality, disease progression biomarkers
- MeSH terms
- Circadian Rhythm, Darkness, Female, Health Status, Humans, Leukocytes, Male, Middle Aged, Parkinson Disease, RNA, Messenger, Severity of Illness Index, Sleep Wake Disorders, Time Factors, Case-Control Studies, Photoperiod, Reverse Transcriptase Polymerase Chain Reaction, ARNTL Transcription Factors, Period Circadian Proteins
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