Allergy and risk of glioma: a meta-analysis
Abstract
We evaluated the association between allergic conditions and the risk of glioma in case-control and cohort studies published so far on this issue. A total of 12 studies (10 case-control and 2 cohort studies) were included in the analysis, involving 61 090 participants, of whom 6408 had glioma. When compared with non-allergic conditions, the pooled odds ratio (OR) with any allergic conditions for glioma was 0.60 (95% CI: 0.52-0.69, P<0.001), suggesting a significant negative association (protective effect) between allergy and glioma. Subgroup analysis showed that the ORs were 0.70 (95% CI: 0.62-0.79, P<0.001), 0.69 (95% CI: 0.62-0.78, P<0.001), and 0.78 (95% CI: 0.70-0.87, P<0.001) for asthma, eczema, and hay fever, respectively. The significant association remained even after excluding the bias of proxy reporting (OR=0.61; 95% CI: 0.50-0.75, P<0.001). We conclude that allergic conditions may significantly reduce the risk of glioma.
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Seven meta-analyses comprised studies with high (>90%) average power.
“However, seven meta-analyses comprised studies with high (>90%) average power 24,26,31,57,63,68,71 .”
From Power failure: why small sample size undermines the reliability of neuroscience (2013) · cites this paper as [31]
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Power failure: why small sample size undermines the reliability of neuroscience
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Comorbidities of Atopic Dermatitis: Beyond Rhinitis and Asthma
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- Authors
- Chen, C., Xu, T., Chen, J., Zhou, J., Yan, Y., Lu, Y., & Wu, S.
- Affiliations
- Second Military Medical University (CN)
- Stony Brook University Hospital (US)
- Corresponding author
- Chen, C.
- Chen, J.
- Venue
- European Journal of Neurology
- Publisher
- Wiley
- Published
- 2010-08-16
- Volume
- 18
- Issue
- 3
- Pages
- 387-395
- ISSN
- 1351-5101 (ISSN-L)
- OpenAlex
- W1889894657
- Cited by
- 100
- References
- 33
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 3 · 2022: 4 · 2021: 6 · 2020: 3 · 2019: 6 · 2018: 7 · 2017: 13 · 2016: 9 · 2015: 8 · 2014: 15 · 2013: 14 · 2012: 2
- FWCI
- 0.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Genetics › Glioma Diagnosis and Treatment
- Health Sciences › Medicine › Oncology › Cancer Risks and Factors
- Health Sciences › Medicine › Oncology › Global Cancer Incidence and Screening
- Keywords
- glioma, allergy, allergic diseases, asthma, atopic dermatitis, allergic rhinitis, cancer risk, protective effect, brain tumors
- MeSH terms
- Brain Neoplasms, Glioma, Humans, Hypersensitivity, Risk Factors, Incidence, Odds Ratio, Case-Control Studies
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