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Cited by 155Parkinson's Disease Mechanisms and TreatmentsHelicobacter pylori-related gastroenterology studiesNeurological disorders and treatments

Treatment for Helicobacter pylori infection and risk of parkinson’s disease in Denmark

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Nielsen, H. H., Qiu, J., Friis, S., Wermuth, L., Ritz, B.·2012·European Journal of Neurology
DOI 10.1111/j.1468-1331.2011.03643.xPMC PMC3330170
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Abstract

Background and purpose: It has been speculated that gastrointestinal infection with Helicobacter pylori (HP) contributes to the development of Parkinson’s disease (PD). We used nationwide Danish registers to investigate this hypothesis. Methods: We identified 4484 patients with a first time PD diagnosis between 2001 and 2008 from the Danish National Patient Register (DNPR) and 22 416 population controls from the Danish Civil Registration System (CRS). Information on drug use was obtained from the National Prescription Registry (NPR). We used logistic regression to compute odds ratios (OR) for the association between treatment for HP and risk of PD. Results: Prescriptions for HP‐eradication drugs and proton pump inhibitors (PPI) 5 or more years prior to the diagnosis of PD were associated with a 45% and 23% increase in PD risk, respectively. Hospitalizations and outpatient visits for gastritis and peptic/duodenal ulcers, however, were not associated with PD. Conclusions: Our population‐based study suggests that chronic HP infections and/or gastritis contribute to PD or that these are PD‐related pathologies that precede motor symptoms.

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  • H. pylori infection is associated with PD risk.

    “In a similar vein, H. pylori infection, associated with PD risk [110, 111], is thought to contribute to motor dysfunction at late stages by reducing levodopa bioavailability, and at early stages through induction of local and systemic inflammation.”

    From The gut–brain axis in early Parkinson’s disease: from prodrome to prevention (2025) · cites this paper as [110]

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Authors
Nielsen, H. H., Qiu, J., Friis, S., Wermuth, L., & Ritz, B.
Affiliations
  • Odense University Hospital (DK)
  • University of California, Los Angeles (US)
  • Danish Cancer Society (DK)
Corresponding author
Nielsen, H. H.
ORCID
Venue
European Journal of Neurology
Publisher
Wiley
Published
2012-01-17
Volume
19
Issue
6
Pages
864-869
ISSN
  • 1351-5101 (ISSN-L)
  • 1468-1331
DOI
10.1111/j.1468-1331.2011.03643.x
PMC
PMC3330170
OpenAlex
W2160327148
Cited by
155
References
0
Citations by year
2026: 7 · 2025: 9 · 2024: 16 · 2023: 13 · 2022: 10 · 2021: 14 · 2020: 16 · 2019: 12 · 2018: 4 · 2017: 10 · 2016: 4 · 2015: 15 · 2014: 11 · 2013: 7 · 2012: 7
FWCI
8.36
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • European Journal of Neurology (publishedVersion)
  • PubMed (publishedVersion)
  • University of Southern Denmark Research Portal (University of Southern Denmark) (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Institute of Neurological Disorders and Stroke (P50NS038367)
  • National Institute of Environmental Health Sciences (R01ES013717)
Topics
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Health Sciences › Medicine › Surgery › Helicobacter pylori-related gastroenterology studies
  • Health Sciences › Medicine › Neurology › Neurological disorders and treatments
Keywords
Helicobacter pylori infection, Parkinson's disease, H. pylori eradication therapy, proton pump inhibitors, gastritis, peptic ulcer, duodenal ulcer, gastrointestinal infections, disease risk
MeSH terms
Adult, Aged, Aged, 80 and over, Anti-Bacterial Agents, Denmark, Female, Humans, Male, Middle Aged, Parkinson Disease, Retrospective Studies, Risk, Logistic Models, Helicobacter Infections, Proton Pump Inhibitors

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