Neuroinflammation in Parkinson's disease and its potential as therapeutic target

α-Synuclein in Lewy bodies

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Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease

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Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

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ATP mediates rapid microglial response to local brain injury in vivo

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Mechanisms underlying inflammation in neurodegeneration

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Hereditary Early-Onset Parkinson's Disease Caused by Mutations in <i>PINK1</i>

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Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology

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Reactive microglia are positive for HLA‐DR in the substantia nigra of Parkinson's and Alzheimer's disease brains

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Cloning of the Gene Containing Mutations that Cause PARK8-Linked Parkinson's Disease

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Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases

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The prevalence of Parkinson's disease: a systematic review and meta-analysis

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Neuroinflammation in Parkinson’s disease: A target for neuroprotection?

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PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

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Genome-wide association study reveals genetic risk underlying Parkinson's disease

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Microglia and inflammation-mediated neurodegeneration: Multiple triggers with a common mechanism

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Control of microglial neurotoxicity by the fractalkine receptor

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Microglia/Macrophage Polarization Dynamics Reveal Novel Mechanism of Injury Expansion After Focal Cerebral Ischemia

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Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease

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Aggregated α‐synuclein activates microglia: a process leading to disease progression in Parkinson's disease

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In vivo imaging of microglial activation with [11C](R)-PK11195 PET in idiopathic Parkinson's disease

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Epidemiology and etiology of Parkinson's disease: a review of the evidence

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Blockade of Microglial Activation Is Neuroprotective in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Mouse Model of Parkinson Disease

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Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease

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Down-Regulation of the Macrophage Lineage Through Interaction with OX2 (CD200)

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Description of Parkinson's Disease as a Clinical Syndrome

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A Nurr1/CoREST Pathway in Microglia and Astrocytes Protects Dopaminergic Neurons from Inflammation-Induced Death

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Characterization of Mechanisms Involved in Transrepression of NF-κB by Activated Glucocorticoid Receptors

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Blood–brain barrier dysfunction in parkinsonian midbrain in vivo

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Aspirin triggers previously undescribed bioactive eicosanoids by human endothelial cell-leukocyte interactions.

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Toll‐like receptor 4 is required for α‐synuclein dependent activation of microglia and astroglia

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Prevalence and incidence of Parkinson's disease in Europe

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Neuroinflammation in Parkinson's disease

Hirsch, E. C., Vyas, S., & Hunot, S. (2012) · Parkinsonism &amp; Related Disorders · doi:10.1016/s1353-8020(11)70065-7 · Cited by 586 · see citing works

Triggering of inflammasome by aggregated α-synuclein, an inflammatory response in synucleinopathies

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Neuroinflammatory mechanisms in Parkinson's disease: Potential environmental triggers, pathways, and targets for early therapeutic intervention

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Synuclein activates microglia in a model of Parkinson's disease

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Microglia/Macrophage Polarization Dynamics in White Matter after Traumatic Brain Injury

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The expression of DJ-1 (PARK7) in normal human CNS and idiopathic Parkinson's disease

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LRRK2 Inhibition Attenuates Microglial Inflammatory Responses

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Suppression of neuroinflammation by astrocytic dopamine D2 receptors via αB-crystallin

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LRRK2 Is Involved in the IFN-γ Response and Host Response to Pathogens

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Lymphoid/Neuronal Cell Surface OX2 Glycoprotein Recognizes a Novel Receptor on Macrophages Implicated in the Control of Their Function

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Targeted Overexpression of Human α-Synuclein Triggers Microglial Activation and an Adaptive Immune Response in a Mouse Model of Parkinson Disease

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The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease

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Nitrated α–Synuclein Immunity Accelerates Degeneration of Nigral Dopaminergic Neurons

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Blocking Soluble Tumor Necrosis Factor Signaling with Dominant-Negative Tumor Necrosis Factor Inhibitor Attenuates Loss of Dopaminergic Neurons in Models of Parkinson's Disease

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Minocycline inhibits microglial activation and protects nigral cells after 6-hydroxydopamine injection into mouse striatum

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Naloxone Protects Rat Dopaminergic Neurons against Inflammatory Damage through Inhibition of Microglia Activation and Superoxide Generation

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A Progressive Mouse Model of Parkinson’s Disease: The Thy1-aSyn (“Line 61”) Mice

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Astrocytic expression of Parkinson's disease-related A53T α-synuclein causes neurodegeneration in mice

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Neuron–glia crosstalk in health and disease: fractalkine and CX 3 CR1 take centre stage

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Anti-inflammatory drugs and risk of Parkinson disease

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Use of ibuprofen and risk of Parkinson disease

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Parkinson’s disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures

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Dynamic changes in pro- and anti-inflammatory cytokines in microglia after PPAR-γ agonist neuroprotective treatment in the MPTPp mouse model of progressive Parkinson's disease

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Parkin Deficiency Increases Vulnerability to Inflammation-Related Nigral Degeneration

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Regionally-specific microglial activation in young mice over-expressing human wildtype alpha-synuclein

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CX3CL1 reduces neurotoxicity and microglial activation in a rat model of Parkinson’s disease

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The degenerative effect of a single intranigral injection of LPS on the dopaminergic system is prevented by dexamethasone, and not mimicked by rh‐TNF‐α, IL‐1β and IFN‐γ

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Progressive neurodegeneration and motor disabilities induced by chronic expression of IL-1β in the substantia nigra

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Lewy bodies in Parkinson's disease are recognized by antibodies to complement proteins

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Jmjd3 is essential for the epigenetic modulation of microglia phenotypes in the immune pathogenesis of Parkinson’s disease

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Parkinson's disease-linked leucine-rich repeat kinase 2(R1441G) mutation increases proinflammatory cytokine release from activated primary microglial cells and resultant neurotoxicity

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Blood vessels change in the mesencephalon of patients with Parkinson's disease

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Aspirin and Salicylate Protect Against MPTP‐Induced Dopamine Depletion in Mice

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Ulcerative colitis exacerbates lipopolysaccharide‐induced damage to the nigral dopaminergic system: potential risk factor in Parkinson`s disease

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Selective COX-2 inhibition prevents progressive dopamine neuron degeneration in a rat model of Parkinson's disease.

Sánchez‐Pernaute, R., Ferree, A. W., Cooper, O., Yu, M., Brownell, A., & Ole Isacson, A. (2004) · Journal of Neuroinflammation · doi:10.1186/1742-2094-1-6 · Cited by 205 · see citing works

Minocycline Reduces the Lipopolysaccharide-Induced Inflammatory Reaction, Peroxynitrite-Mediated Nitration of Proteins, Disruption of the Blood–Brain Barrier, and Damage in the Nigral Dopaminergic System

Tomás-Camardiel, M., Rite, I., Herrera, A. J., de Pablos, R. M., Cano, J., Machado, A., & Venero, J. L. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.01.010 · Cited by 203 · see citing works

Impaired Inflammatory Responses in Murine Lrrk2-Knockdown Brain Microglia

Kim, B., Yang, M.-S., Choi, D., Kim, J.-H., Kim, H.-S., Seol, W., Choi, S., Jou, I., Kim, E.-Y., & Joe, E.-H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034693 · Cited by 202 · see citing works

A pivotal role of matrix metalloproteinase‐3 activity in dopaminergic neuronal degeneration via microglial activation

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Vascular Degeneration in <scp>P</scp>arkinson's Disease

Guan, J., Pavlovic, D., Dalkie, N., Waldvogel, H. J., O'Carroll, S. J., Green, C. R., & Nicholson, L. F. B. (2013) · Brain Pathology · doi:10.1111/j.1750-3639.2012.00628.x · Cited by 191 · see citing works

Deleterious Effects of Minocycline in Animal Models of Parkinson’s Disease and Huntington’s Disease

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Increased Mitochondrial Calcium Sensitivity and Abnormal Expression of Innate Immunity Genes Precede Dopaminergic Defects in Pink1-Deficient Mice

Akundi, R. S., Huang, Z., Eason, J., Pandya, J. D., Zhi, L., Cass, W. A., Sullivan, P. G., & Büeler, H. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016038 · Cited by 187 · see citing works

Regulation of astrocyte inflammatory responses by the Parkinson's disease‐associated gene DJ–1

Waak, J., Weber, S. S., Waldenmaier, A., Görner, K., Alunni‐Fabbroni, M., Schell, H., Weisenhorn, D. M. V., Pham, T., Reumers, V., Baekelandt, V., et al. (2009) · The FASEB Journal · doi:10.1096/fj.08-125153 · Cited by 186 · see citing works

Purinergic receptors in microglia: Functional modal shifts of microglia mediated by P2 and P1 receptors

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Causes of death in a community-based study of Parkinson's disease: Causes of death in Parkinson's disease

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[11C]-PK11195 PET: Quantification of neuroinflammation and a monitor of anti-inflammatory treatment in Parkinson's disease?

Bartels, A. L., Willemsen, A. T. M., Doorduin, J., de Vries, E. F. J., Dierckx, R. A., & Leenders, K. L. (2009) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2009.05.005 · Cited by 181 · see citing works

Interleukin-1β and tumor necrosis factor-α: reliable targets for protective therapies in Parkinson’s Disease?

Leal, M. C., Casabona, J. C., Puntel, M., & Pitossi, F. J. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00053 · Cited by 175 · see citing works

Neuronal expression of CD22: Novel mechanism for inhibiting microglial proinflammatory cytokine production

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Activation of Dopamine D2 Receptor Suppresses Neuroinflammation Through αB-Crystalline by Inhibition of NF-κB Nuclear Translocation in Experimental ICH Mice Model

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