The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Loss of temporal retinal nerve fibers in Parkinson disease: a mitochondrial pattern?
Abstract
BACKGROUND AND PURPOSE: Optic nerve involvement is frequent in mitochondrial disease, and retinal abnormalities are described in Parkinson's disease (PD). METHODS: We evaluated retinal nerve fiber layer (RNFL) thickness by optical coherence tomography in 43 patients with PD and in 86 age-matched controls. We considered separately the eyes ipsilateral and contralateral to the most affected body side in patients with PD. ancova analysis, Pearson test, and multiple regression analysis were used (P < 0.05). RESULTS: Patients with PD showed significantly thinner temporal RNFL thickness compared to controls (P = 0.004), more evident in the eye contralateral to the most affected body side. Average RNFL thickness significantly correlated with age in both controls and patients with PD (P-values ranging from 0.001 to 0.019), whereas in patients with PD RNFL thickness did not correlate with clinical variables. CONCLUSIONS: Our study reveals a loss of retinal nerve fibers in the temporal quadrant in PD, which is typically susceptible in mitochondrial optic neuropathies.
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“Moreover, abnormalities in visual function have been reported (Bodis-Wollner, 1990; Nowacka et al., 2014) in PD patients and correlated with changes in retinal tissue (La Morgia et al., 2013; Yu et al., 2014) (Table 1).”
From The role of microglia in retinal neurodegeneration: Alzheimer’s disease, parkinson, and glaucoma. (2017) · cites this paper as La Morgia et al., 2013
Citations
Cites
Epidemiology of Parkinson's disease
de Lau, L. M., & Breteler, M. M. (2006) · The Lancet Neurology · doi:10.1016/s1474-4422(06)70471-9 · Cited by 4,110
Diagnostic Criteria for Parkinson Disease
Gelb, D. J., Oliver, E., & Gilman, S. (1999) · Archives of Neurology · doi:10.1001/archneur.56.1.33 · Cited by 2,822
Mitochondria in the aetiology and pathogenesis of Parkinson's disease
Schapira, A. H. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70327-7 · Cited by 883
Retinal nerve fiber layer thinning in Parkinson disease
Inzelberg, R., Ramirez, J. A., Nisipeanu, P., & Ophir, A. (2004) · Vision Research · doi:10.1016/j.visres.2004.06.009 · Cited by 343 · cited 1×
“Optic nerve pathology in PD has been previously documented by others, some reporting a preferential loss of fibers in the infero-temporal quadrants, consistent with the involvement of the papillomacular bundle [9,10,13].”
ResultInner Retinal Layer Thinning in Parkinson Disease
Hajee, M. E. (2009) · Archives of Ophthalmology · doi:10.1001/archophthalmol.2009.106 · Cited by 269
Barboni, P., Savini, G., Valentino, M. L., Montagna, P., Cortelli, P., DeNegri, A. M., Sadun, F., BIANCHI, S., Longanesi, L., & Zanini, M. (2004) · Ophthalmology · doi:10.1016/j.ophtha.2004.06.034 · Cited by 246
Nonmotor manifestations of Parkinson's disease
Simuni, T., & Sethi, K. D. (2009) · Annals of Neurology · doi:10.1002/ana.21472 · Cited by 242
Altıntaş, Ö., İşeri, P., Özkan, B., & Çağlar, Y. (2007) · Documenta Ophthalmologica · doi:10.1007/s10633-007-9091-8 · Cited by 240
Retinal ganglion cell neurodegeneration in mitochondrial inherited disorders
Carelli, V., Morgia, C. L., Valentino, M. L., Barboni, P., Ross‐Cisneros, F. N., & Sadun, A. A. (2009) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2009.02.024 · Cited by 238
Barboni, P., Carbonelli, M., Savini, G., Ramos, C. D. V. F., Carta, A., Berezovsky, A., Salomão, S. R., Carelli, V., & Sadun, A. A. (2010) · Ophthalmology · doi:10.1016/j.ophtha.2009.07.026 · Cited by 214
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Seleme, N., Mejia-Vergara, A. J., Sultan, W., Asanad, S., Sadun, A. A., & Karanjia, R. (2020) · Advances in Ophthalmology and Optometry · doi:10.1016/j.yaoo.2020.04.004
Dumpala, S. (2020) · Queensland University of Technology · doi:10.5204/thesis.eprints.203959
Animal Models in Neuro Ophthalmology
Normando, E. M., & Cordeiro, M. F. (2020) · Springer eBooks · doi:10.1007/978-3-030-26269-3_19
Gandhi, U., Chhablani, P. P., Nair, A. G., & Chhablani, J. K. (2017) · Springer eBooks · doi:10.1007/978-981-10-5461-7_1
Retinal Disorders in Humans and Experimental ALS Models
Rojas, P., Ramirez, A. I., de Hoz, R., Cadena, M., Salobrar‐García, E., López‐Cuenca, I., Fernández‐Albarral, J. A., Sánchez-Puebla, L., Matamoros, J. A., Salazar, J. J., et al. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.107052
OCT in Parkinson’s Disease and Related Disorders
Zhou, J., Jin, K., Guan, X., Ye, J., & Grzybowski, A. E. (2025) · Springer eBooks · doi:10.1007/978-3-031-72156-4_12
Animal Models in Neuro Ophthalmology
Normando, E. M., Sher, A., Patel, R. P., Arora, N., & Cordeiro, M. F. (2025) · Springer eBooks · doi:10.1007/978-3-031-72156-4_19
Singh, D., Singhal, S., Kanaujia, V., Ranjan, A., Mani, V. E., Paliwal, V. K., Jain, V. K., Aishwarya, A., & Agarwal, R. (2025) · PubMed Central · doi:10.22336/rjo.2025.32
Portaro, G., Giacomelli, M., Grisanti, S., Taruffi, L., Rauso, G. D., Fioravanti, V., Salomone, G., Argenziano, G., Sabadini, R., Toschi, G., et al. (2025) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2025.108134
Retinal nerve fibre layer thickness reflects characteristics of brain grey and white matter
Ayyıldız, N., Mueller, K., Hardikar, S., Beyer, F., Enzenbach, C., Baber, R., Wirkner, K., Zachariae, S., Girbardt, J., Hassett, J. D., et al. (2026) · Imaging Neuroscience · doi:10.1162/imag.a.1174
Metadata
- Authors
- La Morgia, C., Barboni, P., Rizzo, G., Carbonelli, M., Savini, G., Scaglione, C., Capellari, S., Bonazza, S., Giannoccaro, M. P., Calandra‐Buonaura, G., Liguori, R., Cortelli, P., Martinelli, P., Baruzzi, A., & Carelli, V.
- Affiliations
- University of Bologna (IT)
- Istituto delle Scienze Neurologiche di Bologna (IT)
- Fondazione G.B. Bietti (IT)
- ORCID
- Venue
- European Journal of Neurology
- Publisher
- Wiley
- Published
- 2012-03-21
- Volume
- 20
- Issue
- 1
- Pages
- 198-201
- ISSN
- 1351-5101 (ISSN-L)
- 1468-1331
- OpenAlex
- W2152613502
- Cited by
- 110
- References
- 18
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 4 · 2023: 7 · 2022: 9 · 2021: 11 · 2020: 13 · 2019: 12 · 2018: 9 · 2017: 10 · 2016: 10 · 2015: 4 · 2014: 5 · 2013: 6 · 2012: 3
- FWCI
- 3.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Ophthalmology › Glaucoma and retinal disorders
- Health Sciences › Medicine › Ophthalmology › Drug-Induced Ocular Toxicity
- Keywords
- Parkinson's disease, retinal nerve fiber layer thickness, temporal quadrant, mitochondrial optic neuropathy, mitochondrial disease, optic nerve involvement, retinal abnormalities, fellow eye
- MeSH terms
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Mutation, Nerve Fibers, Optic Nerve, Optic Nerve Diseases, Parkinson Disease, Retina, Case-Control Studies, Protein Serine-Threonine Kinases, Tomography, Optical Coherence
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