Mitochondria in the aetiology and pathogenesis of Parkinson's disease

Schapira, Anthony HV

doi:10.1016/s1474-4422(07)70327-7

Cited by 883Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and SignalingMitochondrial Function and Pathology

Mitochondria in the aetiology and pathogenesis of Parkinson's disease

Schapira, Anthony HV·2008·The Lancet Neurology

DOI 10.1016/s1474-4422(07)70327-7

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Abstract

Several biochemical abnormalities have been described in the brains of patients with Parkinson's disease (PD), including oxidative stress and mitochondrial dysfunction. The identification of specific gene mutations that cause PD has reinforced the relevance of oxidative stress and mitochondrial dysfunction in the familial and the sporadic forms of the disease. The proteins that are associated with familial PD--PTEN-induced putative kinase 1 (PINK1), DJ-1, alpha-synuclein, leucine-rich repeat kinase 2, and, possibly, parkin--are either mitochondrial proteins or are associated with mitochondria, and all interface with the pathways of oxidative stress and free radical damage. Insights into the aetiology and pathogenesis of PD provide hope that drugs or cocktails of drugs that might successfully intervene in the pathogenesis and slow the progression of the disease can be derived from the study of the converging rather than diverging pathways to cell dysfunction and death.

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Impairment of mitochondrial complex-I activity has been observed in the substantia nigra, platelets, and skeletal muscle of PD patients, in some but not all studies.
“An impairment of mitochondrial complex-I activity has been observed in the substantia nigra (SN), platelets, and skeletal muscle of PD patients 1, 9-13, in some but not in all studies14, 15.”
From Mitochondrial Approaches for Neuroprotection (2008) · cites this paper as [11]

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BRAIN, SKELETAL MUSCLE AND PLATELET HOMOGENATE MITOCHONDRIAL FUNCTION IN PARKINSON'S DISEASE
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Mitochondrial involvement in Parkinson’s disease, Huntington’s disease, hereditary spastic paraplegia and Friedreich’s ataxia
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The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis
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Mitochondrial DNA haplogroup cluster UKJT reduces the risk of PD
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LRRK2 mutations in Parkinson disease
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Cyclosporin inhibition of apoptosis induced by mitochondrial complex I toxins
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Mitochondrial ND5 mutations in idiopathic Parkinson’s disease
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Proteasomal inhibition causes loss of nigral tyrosine hydroxylase neurons
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Mutation of the Linker Region of the Polymerase γ-1 (POLG1Gene Associated With Progressive External Ophthalmoplegia and Parkinsonism
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Retracted
PINK1 Is Dispensable for Mitochondrial Recruitment of Parkin and Activation of Mitophagy in Cardiac Myocytes
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Authors: Schapira, A. H.
Affiliations: UCL Queen Square Institute of Neurology (GB)
Corresponding author: Schapira, Anthony HV
ORCID: Schapira, Anthony HV
Venue: The Lancet Neurology
Publisher: Elsevier BV
Published: 2008-01
Volume: 7
Issue: 1
Pages: 97-109
ISSN: 1474-4422 (ISSN-L)
DOI: 10.1016/s1474-4422(07)70327-7
OpenAlex: W2139233019
Cited by: 883
References: 166
Citations by year: 2026: 26 · 2025: 31 · 2024: 25 · 2023: 27 · 2022: 42 · 2021: 40 · 2020: 49 · 2019: 35 · 2018: 54 · 2017: 55 · 2016: 45 · 2015: 42 · 2014: 47 · 2013: 56 · 2012: 59
FWCI: 12.33
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Lancet Neurology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Keywords: Parkinson's disease, mitochondria, mitochondrial dysfunction, oxidative stress, PINK1, DJ-1, alpha-synuclein, LRRK2, Parkin, familial Parkinson's disease, sporadic Parkinson's disease, genetic mutations, oxidative damage, neurodegeneration
MeSH terms: Animals, Humans, Models, Biological, Parkinson Disease, Mitochondrial Proteins, Mitochondrial Diseases

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Mitochondria in the aetiology and pathogenesis of Parkinson's disease

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