Clinical Features of Probable Medication-Overuse Headache: A Retrospective Study in Japan
Open accessAbstract
This study examined the clinical picture of probable medication-overuse headache (MOH) and the presence of any features peculiar to Japan. In a retrospective study of 47 patients, type of primary headache, type of medicine overused, method and result of withdrawal were investigated. Among the 47 patients, 80.9% had migraine only, and 85.1% overused combination medications. While 36 patients (76.6%) succeeded in withdrawal, five patients (10.6%) failed. One patient (2.1%) had not improved by 2 months after withdrawal and was diagnosed with chronic migraine and chronic tension-type headache without MOH. The remaining five patients (10.6%) dropped out. All dropout patients were recommended abrupt inpatient withdrawal, but chose abrupt outpatient withdrawal. As features peculiar to Japan, many patients with probable MOH overused combination analgesics, particularly females.
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Patients with medication overuse headache seldom respond to prophylactic treatment if medication overuse for the acute condition continues.
“The diagnosis is very important because patients seldom respond to prophylactic treatment, if the medication overuse for the acute condition continues [3–5].”
From Nabilone for the treatment of medication overuse headache: results of a preliminary double-blind, active-controlled, randomized trial (2012) · cites this paper as [4]
Cites
Sorge, F., Simone, R. D., Marano, E., Nolano, M., Orefice, G., & Carrieri, P. B. (1988) · Cephalalgia · doi:10.1046/j.1468-2982.1988.0801001.x · Cited by 3,464 · see citing works
Goadsby, P. J. (2004) · Cephalalgia · doi:10.1111/j.1468-2982.2004.00711.x · Cited by 2,381 · see citing works
The International Classification of Headache Disorders
Olesen, J. (2008) · Headache The Journal of Head and Face Pain · doi:10.1111/j.1526-4610.2008.01121.x · Cited by 2,321 · see citing works
Silberstein, S., Olesen, J., Bousser, M.-G., Diener, H.-C., Dodick, D., First, M., Goadsby, P., Göbel, H., Lainez, M., Lance, J., et al. (2005) · Cephalalgia · doi:10.1111/j.1468-2982.2005.00878.x · Cited by 517 · see citing works
Medication-overuse headache: a worldwide problem
Diener, H.-C., & Limmroth, V. (2004) · The Lancet Neurology · doi:10.1016/s1474-4422(04)00824-5 · Cited by 455 · see citing works
Prevalence of Migraine in Japan
Sakai, F., & Igarashi, H. (1997) · Cephalalgia · doi:10.1046/j.1468-2982.1997.1701015.x · Cited by 447 · see citing works
Features of medication overuse headache following overuse of different acute headache drugs
Limmroth, V., Katsarava, Z., Fritsche, G., Przywara, S., & Diener, H. (2002) · Neurology · doi:10.1212/wnl.59.7.1011 · Cited by 391 · see citing works
Bigal, M., Rapoport, A., Sheftell, F., Tepper, S., & Lipton, R. (2004) · Cephalalgia · doi:10.1111/j.1468-2982.2004.00691.x · Cited by 275 · see citing works
Clinical features of withdrawal headache following overuse of triptans and other headache drugs
Katsarava, Z., Fritsche, G., Muessig, M., Diener, H., & Limmroth, V. (2001) · Neurology · doi:10.1212/wnl.57.9.1694 · Cited by 272 · see citing works
Clinical features of withdrawal headache following overuse of triptans and other headache drugs
Mauskop, A. (2002) · Neurology · doi:10.1212/wnl.58.9.1443 · Cited by 181 · see citing works
Abrupt outpatient withdrawal of medication in analgesic-abusing migraineurs
Hering, R., & Steiner, T. (1991) · The Lancet · doi:10.1016/0140-6736(91)93129-w · Cited by 102 · see citing works
Long-Term Follow-Up of Patients Treated for Chronic Headache with Analgesic Overuse
Pini, L.-A., Cicero, A., & Sandrini, M. (2001) · Cephalalgia · doi:10.1046/j.1468-2982.2001.00288.x · Cited by 95 · see citing works
Drug-Induced Headache: Long-Term Results of Stationary Versus Ambulatory Withdrawal Therapy
Suhr, B., Evers, S., Bauer, B., Gralow, I., Grotemeyer, K.-H., & Husstedt, I. (1999) · Cephalalgia · doi:10.1111/j.1468-2982.1999.1901044.x · Cited by 83 · see citing works
Lomerizine (KB‐2796), a New Antimigraine Drug
Hara, H., Morita, T., Sukamoto, T., & Cutrer, F. M. (1995) · CNS Drug Reviews · doi:10.1111/j.1527-3458.1995.tb00284.x · Cited by 35 · see citing works
Ward, T. N. (2004) · Primary Care Clinics in Office Practice · doi:10.1016/j.pop.2004.02.008 · Cited by 16 · see citing works
[Long-term prognosis of analgesics abuse headache].
Takase, Y., Kishigami, H., Nakano, M., & Tatsumi, C. (2005) · PubMed · Cited by 2 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Treatment of medication-overuse headache: A systematic review
Chiang, C., Schwedt, T. J., Wang, S., & Dodick, D. W. (2015) · Cephalalgia · doi:10.1177/0333102415593088 · Cited by 194 · see citing works
Pini, L. A., Guerzoni, S., Cainazzo, M. M., Ferrari, A., Sarchielli, P., Tiraferri, I., Ciccarese, M., & Zappaterra, M. (2012) · The Journal of Headache and Pain · doi:10.1007/s10194-012-0490-1 · Cited by 107 · see citing works
Diener, H., Holle, D., Nägel, S., Dresler, T., Gaul, C., Göbel, H., Heinze‐Kuhn, K., Jürgens, T. P., Kropp, P. A., Meyer, B., et al. (2019) · Clinical and Translational Neuroscience · doi:10.1177/2514183x18823377 · Cited by 99 · see citing works
Chronic migraine and chronic daily headache in the Asia-Pacific region: A systematic review
Stark, R. J., Ravishankar, K., Siow, H. C., Lee, K. S., Pepperle, R., & Wang, S. (2012) · Cephalalgia · doi:10.1177/0333102412468677 · Cited by 71 · see citing works
Imai, N., Yagi, N., Kuroda, R., Konishi, T., Serizawa, M., & Kobari, M. (2011) · Cephalalgia · doi:10.1177/0333102410391486 · Cited by 70 · see citing works
Self-citationConsensus of the Brazilian Headache Society on the treatment of chronic migraine
Kowacs, F., Roesler, C. A. D. P., Piovesan, É. J., Sarmento, E. M., de Campos, H. C., Maciel, J. A., Calia, L. C., Barea, L. M., Ciciarelli, M. C., Valênça, M. M., et al. (2019) · Arquivos de Neuro-Psiquiatria · doi:10.1590/0004-282x20190078 · Cited by 51 · see citing works
Find, N. L., Terlizzi, R., Munksgaard, S. B., Bendtsen, L., Tassorelli, C., Nappi, G., Katsarava, Z., Láinez, M. J. A., Goicochea, M. T., Beatriz Shand, K., et al. (2016) · The Journal of Headache and Pain · doi:10.1186/s10194-016-0612-2 · Cited by 46 · see citing works
Dong, Z., Chen, X., Steiner, T. J., Hou, L., Di, H., He, M., Dai, W., Pan, M., Zhang, M., Liu, R., et al. (2014) · Cephalalgia · doi:10.1177/0333102414552533 · Cited by 39 · see citing works
Potential Unmet Needs in Acute Treatment of Migraine in Japan: Results of the OVERCOME (Japan) Study
Takeshima, T., Ueda, K., Komori, M., Zagar, A. J., Kim, Y., Jaffe, D. H., Matsumori, Y., & Hirata, K. (2022) · Advances in Therapy · doi:10.1007/s12325-022-02289-w · Cited by 36 · see citing works
Predictive index for the onset of medication overuse headache in migraine patients
Onaya, T., Ishii, M., Katoh, H., Shimizu, S., Kasai, H., Kawamura, M., & Kiuchi, Y. (2012) · Neurological Sciences · doi:10.1007/s10072-012-0955-7 · Cited by 30 · see citing works
Therapie der Migräneattacke und Prophylaxe der Migräne
Gaul, C., Kropp, P., & Diener, H. (2018) · Nervenheilkunde · doi:10.1055/s-0038-1673598 · Cited by 28 · see citing works
Medication-Overuse Headache in Japan
Kanki, R., Nagaseki, Y., & Sakai, F. (2008) · Cephalalgia · doi:10.1111/j.1468-2982.2008.01736.x · Cited by 23 · see citing works
Deighton, A. M., Harris, L. A., Johnston, K., Hogan, S., Quaranta, L. A., L'Italien, G. J., & Coric, V. (2021) · BMC Neurology · doi:10.1186/s12883-021-02451-x · Cited by 22 · see citing works
Huang, Q., Li, W., Li, N., Wang, J., Tan, G., Chen, L., Qin, G., Liang, X., & Zhou, J. (2013) · The Journal of Headache and Pain · doi:10.1186/1129-2377-14-51 · Cited by 12 · see citing works
Ishii, M., Onaya, T., Katoh, H., Kiuchi, Y., Kasai, H., Kawamura, M., & Shimizu, S. (2012) · Journal of Clinical Neurology · doi:10.3988/jcn.2012.8.4.301 · Cited by 11 · see citing works
Imai, N., Isogai, Y., Shibasaki, Y., Nakai, M., Ishida, M., Ning, X., & Koga, N. (2023) · Neurology and Therapy · doi:10.1007/s40120-023-00531-3 · Cited by 7 · see citing works
Self-citationKatoh, M. I. H. (2015) · Journal of Neurological Disorders · doi:10.4172/2329-6895.1000206 · Cited by 5 · see citing works
Websites offer helpful information concerning consultation with headache specialists
Imai, N., Yagi, N., Konishi, T., Serizawa, M., & Kobari, M. (2009) · Cephalalgia · doi:10.1111/j.1468-2982.2009.01915.x · Cited by 5 · see citing works
Self-citationHaag, G. (2010) · Expert Opinion on Drug Safety · doi:10.1517/14740331003598857 · Cited by 5 · see citing works
Ishibashi, M., Kasai, H., Katoh, H., & Ishii, M. (2018) · Journal of Medical - Clinical Research & Reviews · doi:10.33425/2639-944x.1047 · Cited by 3 · see citing works
Medication Overuse and Headache
Mitsikostas, D. D., & Jumah, M. A. (2011) · Springer eBooks · doi:10.1007/978-88-470-1700-9_50 · Cited by 3 · see citing works
(MA), W. E. 4. M. P. [. M. A. 4. F. 5. W. M. W. A., (MO), 3. W. M. W. A., 6 with both MA and MO at different times; 36.4 10.3 years of age] and 22 MOH patients who had migraine (1 male and 21 females: 1 with MA and 21 with MO; 39.6 9.9 years of age) who were seen in an outpatient clinic of the Department of Neurology, Showa University East Hospital, Tokyo, Japan, (64%), B. M. 2. A. J. 2. T. S. W. T. S. A. T. I. I. A. P. S. [. T. I. O. D. W. S. H. I. M. P. T. I. M. P. (. <. 0. 0. [. T. M. T. W. O. W. C. A. I. 1. P., (41%), A. I. 9. P., & [16]., A. T. I. 2. P. (. (2015) · Integrative Molecular Medicine · doi:10.15761/imm.1000117 · Cited by 3 · see citing works
Tryptophan hydroxylase 2 gene polymorphisms in Japanese patients with medication overuse headaches.
Ishii, M., Katoh, H., Onaya, T., Kasai, H., Kawamura, M., & Shimizu, S. (2013) · PubMed · Cited by 3 · see citing works
Negative predictors of clinical response to amitriptyline in Japanese patients with migraine
Naito, Y., Ishii, M., Ishibashi, M., Kasai, H., & Katoh, H. (2018) · Neurology and Clinical Neuroscience · doi:10.1111/ncn3.12209 · Cited by 2 · see citing works
Ishii, M., Yahara, M., Katoh, H., Kawamura, M., & Shimizu, S. (2014) · Cited by 2 · see citing works
Ishii, M., Ito, I., & Katoh, H. (2025) · BPB Reports · doi:10.1248/bpbreports.8.5_128 · Cited by 1 · see citing works
Antioxidant Enzyme Gene Polymorphisms in Japanese Migraine Patients with Medication Overuse Headache
Ishii, M., Hirano, T., & Katoh, H. (2015) · International Journal of Neurology Research · doi:10.17554/j.issn.2313-5611.2015.01.33 · Cited by 1 · see citing works
Ishii, M., Katoh, H., Kijima, T., & Ito, I. (2023) · BPB Reports · doi:10.1248/bpbreports.6.6_229 · Cited by 1 · see citing works
Sala, I. (2010) · Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona)
Current status of migraine chronification in Japan
Kowa, H. (2013) · Rinsho Shinkeigaku · doi:10.5692/clinicalneurol.53.1223
S, M. R. A., Garcia, R. G., & Arturo, F. (2010)
ITAHASHI, M., Yoshitani, M., Kaketa, A., Morishita, T., Hori, K., Kawase, T., Ishibashi, C., Sugeta, S., Shibata, K., & Yamamoto, H. (2019) · Japanese Journal of Oral Diagnosis / Oral Medicine · doi:10.15214/jsodom.32.178
Liu, H., Liu, J., Sun, S., Dai, W., Nie, B., Xu, B., Dong, Z., & Yu, S. (2021) · Research Square · doi:10.21203/rs.3.rs-968662/v1
Deighton, A. M., Harris, L. A., Johnston, K., Hogan, S., Quaranta, L. A., L’Italien, G., & Coric, V. (2021) · Figshare · doi:10.6084/m9.figshare.16921436
- Authors
- Imai, N., Kitamura, E., Konishi, T., Suzuki, Y., Serizawa, M., & Okabe, T.
- Affiliations
- Shizuoka Red Cross Hospital (JP)
- Corresponding author
- Imai, N
- Venue
- Cephalalgia
- Publisher
- SAGE Publications
- Published
- 2007-09
- Volume
- 27
- Issue
- 9
- Pages
- 1020-1023
- ISSN
- 0333-1024 (ISSN-L)
- 1468-2982
- OpenAlex
- W2082860769
- Cited by
- 34
- References
- 16
- Citations by year
- 2025: 1 · 2023: 2 · 2022: 1 · 2021: 3 · 2019: 3 · 2018: 3 · 2016: 1 · 2015: 4 · 2014: 2 · 2013: 3 · 2012: 4
- FWCI
- 1.01
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cephalalgia (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Migraine and Headache Studies
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Health Sciences › Health Professions › Complementary and Manual Therapy › Temporomandibular Joint Disorders
- Keywords
- medication overuse headache, migraine, analgesic combination, drug withdrawal, chronic migraine, tension-type headache, sex differences, Japan
- MeSH terms
- Adult, Aged, Analgesics, Female, Headache, Humans, Japan, Male, Medication Errors, Middle Aged, Retrospective Studies, Risk Factors, Prevalence, Risk Assessment
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