Medication-overuse headache: a worldwide problem
Abstract
Medication overuse and subsequent medication-overuse headache (MOH) is a growing problem worldwide. Epidemiological data suggest that up to 4% of the population overuse analgesics and other drugs for the treatment of pain conditions such as migraine and that about 1% of the general population in Europe, North America, and Asia have MOH. Recent clinical studies gave further insights in clinical and pharmacological features, such as critical monthly doses and frequencies. These features seem to vary significantly and depend on the primary headache disorder and the type of drug that is overused. Along with these findings the new international classification of headache disorders has now incorporated additional criteria and new headache entities that will facilitate the diagnosis of MOH. Withdrawal therapy is the only treatment for this disorder and clear restriction of monthly doses is the central requirement for successful prevention.
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Medication overuse headache treatment has few evidence-based indications.
“Medication overuse headache (MOH) is a severe burden to sufferers and its treatment has few evidence-based indications.”
From Nabilone for the treatment of medication overuse headache: results of a preliminary double-blind, active-controlled, randomized trial (2012) · cites this paper as [6]
In these patients, the main unresolved problem is excessive use of drugs for acute treatment and overall deterioration in quality of life, so headache symptoms should be considered as part of the issue as a whole.
“In these patients, the main unresolved problem is the excessive use of drugs for the acute treatment and the overall deterioration experienced in their quality of life, so the headache symptoms should be considered as part of the issue as a whole [2, 6, 7].”
From Nabilone for the treatment of medication overuse headache: results of a preliminary double-blind, active-controlled, randomized trial (2012) · cites this paper as [6]
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- Authors
- Diener, H.-C., & Limmroth, V.
- Affiliations
- Essen University Hospital (DE)
- Corresponding author
- Diener, Hans-Christoph
- ORCID
- Limmroth, Volker
- Venue
- The Lancet Neurology
- Publisher
- Elsevier BV
- Published
- 2004-08
- Volume
- 3
- Issue
- 8
- Pages
- 475-483
- ISSN
- 1474-4422 (ISSN-L)
- OpenAlex
- W2115215127
- Cited by
- 455
- References
- 82
- Citations by year
- 2026: 6 · 2025: 13 · 2024: 12 · 2023: 18 · 2022: 20 · 2021: 16 · 2020: 22 · 2019: 19 · 2018: 19 · 2017: 15 · 2016: 19 · 2015: 20 · 2014: 23 · 2013: 26 · 2012: 26
- FWCI
- 2.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Migraine and Headache Studies
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
- Keywords
- medication overuse headache, analgesic overuse, migraine, headache frequency, International Classification of Headache Disorders, withdrawal therapy, headache prevention
- MeSH terms
- Diagnosis, Differential, Headache, Humans, Prognosis, Outcome Assessment, Health Care, Headache Disorders, Drug-Related Side Effects and Adverse Reactions
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