Cited by 455Migraine and Headache StudiesTraumatic Brain Injury ResearchPharmaceutical Practices and Patient Outcomes

Medication-overuse headache: a worldwide problem

Diener, Hans-Christoph, Limmroth, Volker·2004·The Lancet Neurology

Abstract

Medication overuse and subsequent medication-overuse headache (MOH) is a growing problem worldwide. Epidemiological data suggest that up to 4% of the population overuse analgesics and other drugs for the treatment of pain conditions such as migraine and that about 1% of the general population in Europe, North America, and Asia have MOH. Recent clinical studies gave further insights in clinical and pharmacological features, such as critical monthly doses and frequencies. These features seem to vary significantly and depend on the primary headache disorder and the type of drug that is overused. Along with these findings the new international classification of headache disorders has now incorporated additional criteria and new headache entities that will facilitate the diagnosis of MOH. Withdrawal therapy is the only treatment for this disorder and clear restriction of monthly doses is the central requirement for successful prevention.

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Crossref · 10.1016/s1474-4422(04)00824-5

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Authors
Diener, H.-C., & Limmroth, V.
Affiliations
Essen University Hospital (DE)
Corresponding author
Diener, Hans-Christoph
Venue
The Lancet Neurology
Publisher
Elsevier BV
Published
2004-08
Volume
3
Issue
8
Pages
475-483
ISSN
1474-4422 (ISSN-L)
OpenAlex
W2115215127
Cited by
455
References
82
Citations by year
2026: 6 · 2025: 13 · 2024: 12 · 2023: 18 · 2022: 20 · 2021: 16 · 2020: 22 · 2019: 19 · 2018: 19 · 2017: 15 · 2016: 19 · 2015: 20 · 2014: 23 · 2013: 26 · 2012: 26
FWCI
2.48
Type
journal article
Language
en
Open access
closed
Locations
  • The Lancet Neurology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Migraine and Headache Studies
  • Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
  • Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
Keywords
medication overuse headache, analgesic overuse, migraine, headache frequency, International Classification of Headache Disorders, withdrawal therapy, headache prevention
MeSH terms
Diagnosis, Differential, Headache, Humans, Prognosis, Outcome Assessment, Health Care, Headache Disorders, Drug-Related Side Effects and Adverse Reactions

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