Spreading Depression Enhances Human Neocortical Excitability in vitro
Abstract
Cortical spreading depression (CSD) plays a role in migraine with aura. However, studies of the neuronal effects of CSD in human cortex are scarce. Therefore, in the present study, the effects of CSD on the field excitatory postsynaptic potentials (fEPSP) and the induction of long-term potentiation (LTP) were investigated in human neocortical slices obtained during epilepsy surgery. CSD significantly enhanced the amplitude of fEPSP following a transient suppressive period and increased the induction of LTP in the third layer of neocortical tissues. These results indicate that CSD facilitates synaptic excitability and efficacy in human neocortical tissues, which can be assumed to contribute to hyperexcitability of neocortical tissues in patients suffering from migraine.
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Procedures assumed to induce local net increases in synaptic potentiation (e.g., the cortical application of BDNF and KCl) induced cortical spreading depression and increased SWA during subsequent sleep, whereas BDNF receptor inhibition decreased SWA.
“Procedures assumed to induce local net increases in synaptic potentiation (e.g., the cortical application of BDNF and KCl) induced cortical spreading depression (81) and increased SWA during subsequent sleep, whereas BDNF receptor inhibition decreased SWA (366,367).”
From About Sleep's Role in Memory (2013) · cites this paper as [81]
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Mechanisms of migraine aura revealed by functional MRI in human visual cortex
Hadjikhani, N. K., del Río, M. S., Wu, O., Schwartz, D., Bakker, D., Fischl, B. R., Kwong, K. K., Cutrer, F. M., Rosen, B. R., Tootell, R. B. H., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.071582498 · Cited by 1,521 · see citing works
Mechanisms of Spreading Depression and Hypoxic Spreading Depression-Like Depolarization
Somjen, G. G. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.3.1065 · Cited by 1,124 · see citing works
Spreading depression: a review of the clinical relevance
Gorji, A. (2001) · Brain Research Reviews · doi:10.1016/s0165-0173(01)00081-9 · Cited by 308 · see citing works
Self-citationRecent advances in understanding migraine mechanisms, molecules and therapeutics
Goadsby, P. J. (2006) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2006.11.005 · Cited by 279 · see citing works
Magnetoencephalographic fields from patients with spontaneous and induced migraine aura
Bowyer, S. M., Aurora, S. K., Moran, J. E., Tepley, N., & Welch, K. M. A. (2001) · Annals of Neurology · doi:10.1002/ana.1293 · Cited by 251 · see citing works
The Occipital Cortex Is Hyperexcitable in Migraine: Experimental Evidence
Aurora, S., Cao, Y., Bowyer, S. M., & Welch, K. M. A. (1999) · Headache The Journal of Head and Face Pain · doi:10.1046/j.1526-4610.1999.3907469.x · Cited by 195 · see citing works
Suppression of perception in migraine
Mulleners, W. M., Chronicle, E. P., Palmer, J. E., et al. (2001) · Neurology · doi:10.1212/wnl.56.2.178 · Cited by 120 · see citing works
Mechanisms of Increased Sensitivity to Noise and Light in Migraine Headache
Woodhouse, A., & Drummond, P. D. (1993) · Cephalalgia · doi:10.1046/j.1468-2982.1993.1306417.x · Cited by 120 · see citing works
Pathophysiology of Headache—Past and Present
Moskowitz, M. A. (2007) · Headache The Journal of Head and Face Pain · doi:10.1111/j.1526-4610.2007.00678.x · Cited by 113 · see citing works
Motion Processing Deficits in Migraine
McKendrick, A. M., & Badcock, D. R. (2004) · Cephalalgia · doi:10.1111/j.1468-2982.2004.00679.x · Cited by 88 · see citing works
Repetitive spreading depression causes selective suppression of GABAergic function
Krüger, H., Luhmann, H. J., & Heinemann, U. (1996) · Neuroreport · doi:10.1097/00001756-199611040-00065 · Cited by 70 · see citing works
Kelman, L. (2004) · Cephalalgia · doi:10.1111/j.1468-2982.2004.00766.x · Cited by 68 · see citing works
Cortical spreading depression induces an LTP-like effect in rat neocortex in vitro
Footitt, D., & Newberry, N. R. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01359-0 · Cited by 61 · see citing works
Pattern reversal visual evoked potentials in classic and common migraine
Shibata, K., Osawa, M., & Iwata, M. (1997) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(96)00258-4 · Cited by 56 · see citing works
Spinal and cortical spreading depression enhance spinal cord activity
Gorji, A., Zahn, P. K., Pogatzki, E. M., et al. (2003) · Neurobiology of Disease · doi:10.1016/j.nbd.2003.09.014 · Cited by 40 · see citing works
Self-citationWelch, K. M. A., Barkley, G. L., Ramadan, N. M., et al. (1992) · PubMed · Cited by 34 · see citing works
Gorji, A., Stemmer, N., Rambeck, B., et al. (2006) · Epilepsia · doi:10.1111/j.1528-1167.2006.00421.x · Cited by 21 · see citing works
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Rasch, B., & Born, J. (2013) · Physiological Reviews · doi:10.1152/physrev.00032.2012 · Cited by 2,783 · see citing works
“, the cortical application of BDNF and KCl) induced cortical spreading depression (81) and increased SWA during subsequent sleep, whereas BDNF receptor inhibition decreased SWA (366, 367).”
BackgroundDreier, J. P., Isele, T., Reiffurth, C., Offenhauser, N., Kirov, S. A., Dahlem, M. A., & Herreras, O. (2013) · The Neuroscientist · doi:10.1177/1073858412453340 · Cited by 94 · see citing works
Faraguna, U., Nelson, A., Vyazovskiy, V. V., Cirelli, C., & Tononi, G. (2010) · Cerebral Cortex · doi:10.1093/cercor/bhq041 · Cited by 54 · see citing works
- Authors
- Berger, M., Speckmann, E.-J., Pape, H., & Gorji, A.
- Affiliations
- University of Münster (DE)
- Institut für Physiologie I, Westfalische Wilhelms-Universitat Munster, Münster, Germany
- Corresponding author
- Gorji, A
- ORCID
- Gorji, A
- Venue
- Cephalalgia
- Publisher
- SAGE Publications
- Published
- 2008-05
- Volume
- 28
- Issue
- 5
- Pages
- 558-562
- ISSN
- 0333-1024 (ISSN-L)
- 1468-2982
- OpenAlex
- W2041914299
- Cited by
- 97
- References
- 17
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 3 · 2023: 4 · 2022: 3 · 2021: 3 · 2020: 3 · 2019: 3 · 2018: 5 · 2017: 7 · 2016: 3 · 2015: 2 · 2014: 12 · 2013: 9 · 2012: 10
- FWCI
- 5.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cephalalgia (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Migraine and Headache Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Keywords
- cortical spreading depression, migraine with aura, human neocortex, field excitatory postsynaptic potentials, long-term potentiation, synaptic excitability, cortical hyperexcitability, epilepsy surgery, neocortical slices
- MeSH terms
- Action Potentials, Adolescent, Adult, Biological Clocks, Cells, Cultured, Female, Humans, Male, Middle Aged, Nerve Net, Cortical Spreading Depression, Neocortex
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