The efficacy of ‘0.05% Clobetasol + 2.5% zinc sulphate’ cream vs. ‘0.05% Clobetasol alone’ cream in the treatment of the chronic hand eczema: a double‐blind study
Abstract
BACKGROUND: Many therapeutic modalities have been suggested for treatment of the chronic hand eczema. Despite good immediate efficacy of some of these treatments, there is high recurrence of the dermatitis following cessation of the treatment. AIM: Regarding the beneficial effects of the zinc sulfate on the skin, we designed a double blind study to evaluate the efficacy of the '0.05% Clobetasol + 2.5% zinc sulphate' cream versus '0.05% Clobetasol alone' cream in the treatment of the chronic hand eczema. SUBJECTS AND METHODS: This study was a double-blind, right to left, prospective, clinical trial. In total, 47 patients with chronic hand eczema admitted to dermatology center of Isfahan University of Medical Sciences were selected and their right hand or left hand were selected at random to be treated with either the '0.05% Clobetasol + 2.5% zinc sulphate' cream or '0.05% Clobetasol alone' cream twice daily for 2 weeks. All of the patients were treated for 2 weeks and were followed up at weeks 2, 4, 6 and 8 after starting the treatment. For determining the severity of chronic hand eczema, we assessed and scored 4 different characteristics of the lesions including redness; scaling; lichenification and pruritus. The data were analyzed using SPSS program (release 13) and statistical tests including Mann-Whitney test. RESULTS: Overall, 47 patients (94 samples) were evaluated. All of these patients had similar and symmetrical lesions on their right and left hands. Out of them, 35 patients were females and 12 patients were male. In all of the evaluated characterisitics, the '0.05% Clobetasol + 2.5% zinc sulphate' cream was more effective than '0.05% Clobetasol alone' cream (P < 0.05). The recurrence rate of eczema was significantly lower in the group treated with this combination treatment (P < 0.05). CONCLUSION: With regard to the encouraging results of the combination treatment with Clobetasol + zinc sulphate, we suggest that in a more extensive clinical trial, the efficacy of this treatment against chronic hand dermatitis be evaluated. In addition, evaluation of this combination therapy against other inflammatory dermatosis seems to be logical.
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A 0.05% Clobetasol + 2.5% zinc sulphate cream applied topically was effective in hand eczemas.
“eczema (a 0.05% Clobetasol + 2.5% zinc sulphate cream applied topically was effective in hand eczemas) [115]”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [115]
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- Authors
- Faghihi, G., Iraji, F., Shahingohar, A., & Saidat, A.
- Affiliations
- Isfahan University of Medical Sciences (IR)
- Corresponding author
- Saidat, AH
- ORCID
- Venue
- Journal of the European Academy of Dermatology and Venereology
- Publisher
- Wiley
- Published
- 2008-02-14
- Volume
- 22
- Issue
- 5
- Pages
- 531-536
- ISSN
- 0926-9959 (ISSN-L)
- 1468-3083
- OpenAlex
- W2059033645
- Cited by
- 28
- References
- 9
- Citations by year
- 2024: 2 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 2 · 2019: 1 · 2017: 2 · 2016: 2 · 2014: 1
- FWCI
- 4.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the European Academy of Dermatology and Venereology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Isfahan University of Medical Sciences
- Topics
- Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Epidemiology › Nail Diseases and Treatments
- Keywords
- chronic hand eczema, clobetasol, zinc sulfate, topical combination therapy, corticosteroid cream, lichenification, pruritus, recurrence rate, combination therapy efficacy
- MeSH terms
- Administration, Topical, Adolescent, Adult, Aged, Aged, 80 and over, Astringents, Child, Chronic Disease, Clobetasol, Double-Blind Method, Drug Therapy, Combination, Eczema, Female, Glucocorticoids, Hand, Humans, Male, Middle Aged, Ointments, Prospective Studies, Recurrence, Severity of Illness Index, Zinc Sulfate
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