Zinc Therapy in Dermatology: A Review
Open accessAbstract
Zinc, both in elemental or in its salt forms, has been used as a therapeutic modality for centuries. Topical preparations like zinc oxide, calamine, or zinc pyrithione have been in use as photoprotecting, soothing agents or as active ingredient of antidandruff shampoos. Its use has expanded manifold over the years for a number of dermatological conditions including infections (leishmaniasis, warts), inflammatory dermatoses (acne vulgaris, rosacea), pigmentary disorders (melasma), and neoplasias (basal cell carcinoma). Although the role of oral zinc is well-established in human zinc deficiency syndromes including acrodermatitis enteropathica, it is only in recent years that importance of zinc as a micronutrient essential for infant growth and development has been recognized. The paper reviews various dermatological uses of zinc.
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Zinc influences the structure and proper functioning of the skin and mucous membranes.
“The element influences the structure and proper functioning of the skin and mucous membranes [98,100].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [98]
Zinc preparations in the form of pastes or ointments cleanse the skin of excess sebum, restore its natural pH, and have astringent, anti-inflammatory and anti-acne effects.
“Zinc preparations in the form of pastes or ointments cleanse the skin of excess sebum, restore its natural pH, and have astringent, anti-inflammatory and anti-acne effects.”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [98]
Zinc is used to treat numerous dermatological conditions, such as infections, inflammatory dermatoses and pigmentary disorders.
“Zinc is used to treat numerous dermatological conditions, such as infections (e.g., warts), inflammatory dermatoses (acne vulgaris, rosacea, atopic dermatitis and alopecia areata) and pigmentary disorders (melasma) [97,98,99,107,110].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [98]
Zinc oxide, due to its ability to reflect and disperse UV rays, is used as a physical filter in sunscreens.
“Zinc oxide, due to its ability to reflect and disperse UV rays, is used as a physical filter in sunscreens [97,98,99,107,110].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [98]
Zinc plays an important role in preventing damage induced by UV radiation and influences collagen metabolism.
“It plays an important role in preventing the damage induced by UV radiation, influences collagen metabolism, exhibits antiandrogen properties by modulating the activity of type 1 and 2 5α-reductase, and also promotes lipogenesis and glucose transport through insulin-like effects on 3T3-L1 fibroblasts and adipocytes [98,107,108].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [98]
Zinc affects the immune function of the skin, modulating macrophage and neutrophil functions, phagocytic activity and various inflammatory cytokines.
“Zinc also affects the immune function of the skin, modulating macrophage and neutrophil functions, phagocytic activity and various inflammatory cytokines [98,99].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [98]
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Pearson, K. (2018) · Journal of Aesthetic Nursing · doi:10.12968/joan.2018.7.sup1.35 · Cited by 14 · see citing works
Iatrogenic copper deficiency: Risks and cautions with zinc prescribing
Duncan, A., Morrison, I., & Bryson, S. M. (2023) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.15749 · Cited by 14 · see citing works
- Authors
- Gupta, M., Mahajan, V. K., Mehta, K. S., & Chauhan, P. S.
- Affiliations
- Dr. Rajendra Prasad Government Medical College (IN)
- Corresponding author
- Mahajan, Vikram K.
- Venue
- Dermatology Research and Practice
- Publisher
- Wiley
- Published
- 2014
- Volume
- 2014
- Pages
- 1-11
- ISSN
- 1687-6105 (ISSN-L)
- 1687-6113
- PMC
- PMC4120804
- OpenAlex
- W1970383836
- Cited by
- 300
- References
- 88
- Citations by year
- 2026: 16 · 2025: 33 · 2024: 30 · 2023: 33 · 2022: 32 · 2021: 28 · 2020: 31 · 2019: 36 · 2018: 22 · 2017: 18 · 2016: 9 · 2015: 11 · 2014: 1
- FWCI
- 1.49
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Dermatology Research and Practice (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
- Keywords
- zinc therapy, zinc oxide, calamine, zinc pyrithione, photoprotection, dandruff, leishmaniasis, warts, acne, rosacea, melasma, basal cell carcinoma, zinc deficiency, acrodermatitis enteropathica, micronutrients, infant development
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