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Cited by 33Cutaneous Melanoma Detection and Managementmelanin and skin pigmentationMelanoma and MAPK Pathways

European ancestry and cutaneous melanoma in Southern Brazil

Bakos, L, Masiero, NCMS, Bakos, RM, Burttet, RM, Wagner, MB, Benzano, D·2009·Journal of the European Academy of Dermatology and Venereology
DOI 10.1111/j.1468-3083.2008.03027.x
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Abstract

Background Similar to other countries, incidence and mortality rates for cutaneous melanoma (CM) are increasing in Brazil. Resulting from centuries of ethnic mixture, the skin of the Brazilian population presents all phototypes, being progressively lighter following the increase of the latitude toward the South, where the highest incidence of melanoma is observed. Studies from the United States and Argentina in whites suggest that European ancestry could represent an important risk factor for CM in those regions. Methods Questionnaires from a case‐control study involving 119 melanoma patients and 177 controls were reviewed for age, gender, phototype, sun exposure, photoprotection and ancestry. The patients reported the countries of ancestry of their grandparents. Data were tabulated and converted into scores that would reflect the proportion of ancestry for each country in individuals. Results Patients with German and Italian ancestry presented higher risk for CM [odds ratio (OR), 3.5; 95% confidence interval (95% CI), 1.8–6.7 and OR, 9.7; 95% CI, 3.9–24.2, respectively]. Conversely, Brazilian indigenous ancestry showed a protective effect for the development of the disease, with an OR of 0.16 (95% CI, 0.04–0.7). Conclusions Some European ancestries, especially German and Italian, seem to be associated to a higher risk of CM in this sample from Southern Brazil. On the other hand, Brazilian indigenous ancestry presented as a protection factor against developing the tumour. Conflicts of interest: None declared

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Crossref · 10.1111/j.1468-3083.2008.03027.x

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  • Melanoma incidence in admixed Hispanics is strongly correlated with European ancestry.

    “Melanoma incidence in admixed Hispanics is strongly correlated with European ancestry (33)(34)(35).”

    From Evidence for recent, population-specific evolution of the human mutation rate (2015) · cites this paper as [34]

  • Melanoma is associated with UV light exposure and European ancestry, occurring at very low rates in Africans, African Americans, and light-skinned Asians.

    “Incidentally, melanoma is not only associated with UV light exposure but also with European ancestry, occurring at very low rates in Africans, African Americans, and even light-skinned Asians (32)(33)(34).”

    From Evidence for recent, population-specific evolution of the human mutation rate (2015) · cites this paper as [34]

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Authors
Bakos, L., Masiero, N., Bakos, R., Burttet, R., Wagner, M., & Benzano, D.
Affiliations
Universidade Federal do Rio Grande do Sul (BR)
Corresponding author
Bakos, L
Venue
Journal of the European Academy of Dermatology and Venereology
Publisher
Wiley
Published
2009-02-09
Volume
23
Issue
3
Pages
304-307
ISSN
  • 0926-9959 (ISSN-L)
  • 1468-3083
DOI
10.1111/j.1468-3083.2008.03027.x
OpenAlex
W2013687507
Cited by
33
References
17
Citations by year
2026: 2 · 2024: 1 · 2023: 1 · 2022: 2 · 2020: 2 · 2019: 1 · 2018: 2 · 2016: 1 · 2015: 3 · 2014: 3 · 2013: 4 · 2012: 2
FWCI
1.59
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Journal of the European Academy of Dermatology and Venereology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Oncology › Cutaneous Melanoma Detection and Management
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Melanoma and MAPK Pathways
Keywords
cutaneous melanoma, European ancestry, German ancestry, Italian ancestry, melanoma risk factors, phototype, sun exposure, photoprotection, southern Brazil
MeSH terms
Adult, Brazil, Female, Humans, Male, Melanoma, Middle Aged, Surveys and Questionnaires, Skin Neoplasms, Case-Control Studies, White People

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