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Cited by 330Tuberculosis Research and EpidemiologyInfectious Diseases and TuberculosisDiagnosis and treatment of tuberculosis

Tuberculosis in HIV-infected patients: a comprehensive review

Open access
Aaron, L., Saadoun, D., Calatroni, I., Launay, O., Mémain, N., Vincent, V., Marchal, G., Dupont, B. +3 more·2004·Clinical Microbiology and Infection
DOI 10.1111/j.1469-0691.2004.00758.x
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Abstract

The incidence of tuberculosis (TB) is currently increasing in HIV-infected patients living in Africa and Asia, where TB endemicity is high, reflecting the susceptibility of this group of patients to mycobacteria belonging to the TB group. In this population, extension of multiple resistance to anti-tuberculous drugs is also a matter of anxiety. HIV-induced immunosuppression modifies the clinical presentation of TB, resulting in atypical signs and symptoms, and more frequent extrapulmonary dissemination. The treatment of TB is also more difficult to manage in HIV-infected patients, particularly with regard to pharmacological interactions secondary to inhibition or induction of cytochrome P450 enzymes by protease inhibitors with rifampicin or rifabutin, respectively. Finally, immune restoration induced by highly active anti-retroviral therapy (HAART) in developed countries may be responsible for a paradoxical worsening of TB manifestations.

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Crossref · 10.1111/j.1469-0691.2004.00758.x

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85 of 85 references verified0 citation errors · 0 not checkable

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  • Extrapulmonary tuberculosis, including lymphatic tuberculosis, is more common among immunocompromised patients, including those with HIV infection.

    “Extrapulmonary tuberculosis, including lymphatic tuberculosis, is more common among immunocompromised patients, including those with HIV infection [20, 21].”

    From Current diagnosis and management of peripheral tuberculous lymphadenitis. (2011) · cites this paper as [20]

  • M tuberculosis lineage strains are associated with the site of tuberculosis disease; strains mostly distributed through Southeast Asia and the Indian Subcontinent (such as M tuberculosis Beijing/W strain) are more likely to cause extrapulmonary disease.

    “A few studies have shown that M tuberculosis lineage strains are associated with the site of tuberculosis disease. The strains mostly distributed through Southeast Asia and the Indian Subcontinent (such as M tuberculosis Beijing/W strain) are more likely to cause extrapulmonary disease.9–11”

    From Epidemiology and Diagnosis of Tuberculous Lymphadenitis in a Tuberculosis Low-Burden Country (2015) · cites this paper as [9]

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Authors
Aaron, L., Saadoun, D., Calatroni, I., Launay, O., Mémain, N., Vincent, V., Marchal, G., Dupont, B., Bouchaud, O., Valeyre, D., & Lortholary, O.
Affiliations
  • Hôpital Necker-Enfants Malades (FR)
  • Hôpital Avicenne (FR)
  • Institut Pasteur (FR)
Corresponding author
Lortholary, O.
ORCID
Venue
Clinical Microbiology and Infection
Publisher
Elsevier BV
Published
2004-05
Volume
10
Issue
5
Pages
388-398
ISSN
1198-743X (ISSN-L)
DOI
10.1111/j.1469-0691.2004.00758.x
OpenAlex
W2095960037
Cited by
330
References
85
Citations by year
2026: 3 · 2025: 13 · 2024: 14 · 2023: 9 · 2022: 16 · 2021: 12 · 2020: 15 · 2019: 11 · 2018: 15 · 2017: 22 · 2016: 15 · 2015: 16 · 2014: 14 · 2013: 14 · 2012: 19
FWCI
2.06
Type
journal article
Language
en
Open access
Licence
Locations
  • Clinical Microbiology and Infection (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
  • Health Sciences › Medicine › Surgery › Infectious Diseases and Tuberculosis
  • Health Sciences › Medicine › Surgery › Diagnosis and treatment of tuberculosis
Keywords
tuberculosis, HIV infection, drug-resistant tuberculosis, extrapulmonary tuberculosis, atypical presentation, protease inhibitors, rifampicin, rifabutin, cytochrome P450 interactions, immune reconstitution, highly active antiretroviral therapy, Mycobacterium tuberculosis
MeSH terms
Antitubercular Agents, Drug Therapy, Combination, Humans, Tuberculosis, HIV Infections, AIDS-Related Opportunistic Infections, Tuberculosis, Multidrug-Resistant, Anti-HIV Agents, Antiretroviral Therapy, Highly Active

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