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A possible role of Bacteroides fragilis enterotoxin in the aetiology of colorectal cancer
Open accessAbstract
The prevalence of enterotoxigenic Bacteroides fragilis (ETBF) was investigated in stool specimens from 73 patients with colorectal cancer and from 59 control patients. Stool specimens were cultured on Bacteroides Bile Esculin agar and B. fragilis was identified by conventional methods. After DNA extraction, the enterotoxin gene (bft) was detected by PCR in 38% of the isolates from colorectal cancer patients, compared with 12% of the isolates from the control group (p 0.009). This is the first study demonstrating an increased prevalence of ETBF in colorectal cancer patients.
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“However, ETBF was reported to be enriched in fecal samples of patients with CRC compared with controls.35, 44, 45”
From Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer (2020) · cites this paper as [44]
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Coburn, B. A., Sekirov, I., Finlay, B. B., Finlay, Dykes, C., & Demeter, L. M. (2007)
대장암에 대한 장내 미생물 무리의 영향과 프로바이오틱스
명대성, & 주영은 (2012)
Metadata
- Authors
- Ulger Toprak, N., Yagci, A., Gulluoglu, B. M., Akin, M. L., Demirkalem, P., Celenk, T., & Soyletir, G.
- Affiliations
- Marmara University (TR)
- ORCID
- Gulluoglu, B.M.
- Venue
- Clinical Microbiology and Infection
- Publisher
- Elsevier BV
- Published
- 2006-08
- Volume
- 12
- Issue
- 8
- Pages
- 782-786
- ISSN
- 1198-743X (ISSN-L)
- OpenAlex
- W1901660111
- Cited by
- 454
- References
- 24
- Citations by year
- 2026: 12 · 2025: 20 · 2024: 30 · 2023: 43 · 2022: 38 · 2021: 34 · 2020: 36 · 2019: 32 · 2018: 33 · 2017: 26 · 2016: 28 · 2015: 28 · 2014: 16 · 2013: 16 · 2012: 20
- FWCI
- 2.88
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Clinical Microbiology and Infection (publishedVersion)
- PubMed (publishedVersion)
- Dspace Repository (Marmara Üniversitesi) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Immunology and Microbiology › Microbiology › Escherichia coli research studies
- Keywords
- Bacteroides fragilis, enterotoxin, enterotoxigenic Bacteroides fragilis, colorectal cancer, cancer etiology, prevalence, gut microbiota
- MeSH terms
- Adult, Aged, Bacterial Toxins, Bacteroides fragilis, Feces, Female, Humans, Male, Metalloendopeptidases, Middle Aged, Colorectal Neoplasms, Cadherins, Interleukin-8
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