Cited by 454Clostridium difficile and Clostridium perfringens researchGut microbiota and healthEscherichia coli research studies

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A possible role of Bacteroides fragilis enterotoxin in the aetiology of colorectal cancer

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Ulger Toprak, N., Yagci, A., Gulluoglu, B.M., Akin, M.L., Demirkalem, P., Celenk, T., Soyletir, G.·2006·Clinical Microbiology and Infection

DOI 10.1111/j.1469-0691.2006.01494.x

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Abstract

The prevalence of enterotoxigenic Bacteroides fragilis (ETBF) was investigated in stool specimens from 73 patients with colorectal cancer and from 59 control patients. Stool specimens were cultured on Bacteroides Bile Esculin agar and B. fragilis was identified by conventional methods. After DNA extraction, the enterotoxin gene (bft) was detected by PCR in 38% of the isolates from colorectal cancer patients, compared with 12% of the isolates from the control group (p 0.009). This is the first study demonstrating an increased prevalence of ETBF in colorectal cancer patients.

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Authors: Ulger Toprak, N., Yagci, A., Gulluoglu, B. M., Akin, M. L., Demirkalem, P., Celenk, T., & Soyletir, G.
Affiliations: Marmara University (TR)
ORCID: Gulluoglu, B.M.
Venue: Clinical Microbiology and Infection
Publisher: Elsevier BV
Published: 2006-08
Volume: 12
Issue: 8
Pages: 782-786
ISSN: 1198-743X (ISSN-L)
DOI: 10.1111/j.1469-0691.2006.01494.x
OpenAlex: W1901660111
Cited by: 454
References: 24
Citations by year: 2026: 12 · 2025: 20 · 2024: 30 · 2023: 43 · 2022: 38 · 2021: 34 · 2020: 36 · 2019: 32 · 2018: 33 · 2017: 26 · 2016: 28 · 2015: 28 · 2014: 16 · 2013: 16 · 2012: 20
FWCI: 2.88
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3072 d)
Locations: Clinical Microbiology and Infection (publishedVersion)
PubMed (publishedVersion)
Dspace Repository (Marmara Üniversitesi) (submittedVersion, other-oa)
Topics: Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Immunology and Microbiology › Microbiology › Escherichia coli research studies
Keywords: Bacteroides fragilis, enterotoxin, enterotoxigenic Bacteroides fragilis, colorectal cancer, cancer etiology, prevalence, gut microbiota
MeSH terms: Adult, Aged, Bacterial Toxins, Bacteroides fragilis, Feces, Female, Humans, Male, Metalloendopeptidases, Middle Aged, Colorectal Neoplasms, Cadherins, Interleukin-8

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A possible role of Bacteroides fragilis enterotoxin in the aetiology of colorectal cancer

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