Cited by 454Clostridium difficile and Clostridium perfringens researchGut microbiota and healthEscherichia coli research studies

The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.

A possible role of Bacteroides fragilis enterotoxin in the aetiology of colorectal cancer

Open access

Ulger Toprak, N., Yagci, A., Gulluoglu, B.M., Akin, M.L., Demirkalem, P., Celenk, T., Soyletir, G.·2006·Clinical Microbiology and Infection

DOI 10.1111/j.1469-0691.2006.01494.x

Open this paper in CoChat — free account

Abstract

The prevalence of enterotoxigenic Bacteroides fragilis (ETBF) was investigated in stool specimens from 73 patients with colorectal cancer and from 59 control patients. Stool specimens were cultured on Bacteroides Bile Esculin agar and B. fragilis was identified by conventional methods. After DNA extraction, the enterotoxin gene (bft) was detected by PCR in 38% of the isolates from colorectal cancer patients, compared with 12% of the isolates from the control group (p 0.009). This is the first study demonstrating an increased prevalence of ETBF in colorectal cancer patients.

Integrity signals

Registry

Crossref · 10.1111/j.1469-0691.2006.01494.x

Cites

24 of 24 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Manual of Clinical Microbiology.
(1980) · Annals of Internal Medicine · doi:10.7326/0003-4819-93-6-939_2 · Cited by 14,435
Tumor Suppressor Genes
Weinberg, R. A. (1991) · Science · doi:10.1126/science.1659741 · Cited by 1,765
Manual of Clinical Microbiology
(1991) · Annals of Internal Medicine · doi:10.7326/0003-4819-115-3-239_2 · Cited by 987
The Genetic Basis of Human Cancer
Michels, V. V. (1999) · Mayo Clinic Proceedings · doi:10.4065/74.1.107-a · Cited by 729
Bacteroides fragilis enterotoxin cleaves the zonula adherens protein, E-cadherin
Wu, S., Lim, K.-C., Huang, J. H. Y., Saidi, R. F., & Sears, C. L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.25.14979 · Cited by 410
Bacteroides fragilis enterotoxin induces c-Myc expression and cellular proliferation
Wu, S., Morin, P. J., Maouyo, D., & Sears, C. L. (2003) · Gastroenterology · doi:10.1053/gast.2003.50047 · Cited by 396
Bacteroides fragilis Enterotoxin Induces Intestinal Epithelial Cell Secretion of Interleukin-8 through Mitogen-Activated Protein Kinases and a Tyrosine Kinase-Regulated Nuclear Factor-κB Pathway
Wu, S., Powell, J., Mathioudakis, N. N., Kane, S., Fernandez, E., & Sears, C. L. (2004) · Infection and Immunity · doi:10.1128/iai.72.10.5832-5839.2004 · Cited by 203
Bacteroides fragilis Enterotoxin Gene Sequences in Patients with Inflammatory Bowel Disease
Prindiville, T. P., Sheikh, R. A., Cohen, S. H., Tang, Y. J., Cantrell, M. C., & Silva, J. (2000) · Emerging infectious diseases · doi:10.3201/eid0602.000210 · Cited by 199
The enterotoxin of Bacteroides fragilis is a metalloprotease
Moncrief, J. S., Obiso, R. J., Barroso, L. A., Kling, J. J., Wright, R. L., Tassell, R. L. V., Lyerly, D. M., & Wilkins, T. D. (1995) · Infection and Immunity · doi:10.1128/iai.63.1.175-181.1995 · Cited by 183
Bacteroides fragilis: a possible cause of acute diarrheal disease in newborn lambs
Myers, L. L., Firehammer, B. D., Shoop, D. S., & Border, M. Μ. (1984) · Infection and Immunity · doi:10.1128/iai.44.2.241-244.1984 · Cited by 155

Show all 24 references

Sorted by citations

Items 401–454 of 454

Is It Rationale to Apply Strict Colonoscopic Surveillance in Patients withHelicobacter pyloriAssociated Chronic Atrophic Gastritis?
Kim, J. H. (2016) · Gut and Liver · doi:10.5009/gnl16445
Mikrobielle Biomarker zur Krebsfrüherkennung
Voigt, A. Y., Zeller, G., & Bork, P. (2018) · TumorDiagnostik & Therapie · doi:10.1055/s-0043-124940
Determinação dos principais patótipos de Escherichia coli isoladas de pacientes com câncer de reto.
Castro, R. L. S. (2018) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.42.2018.tde-13032018-155407
Intestinal-Based Diseases and Peripheral Infection Risk Associated with Gut Dysbiosis: Therapeutic use of Pre- and Probiotics and Fecal Microbiota Transplantation
Tungland, B. C. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-814649-1.00006-5
Rôle des bactéries anaérobies en clinique humaine
Dumont, Y., Michon, A.-L., Laurens, C., Bonzon, L., Jean‐Pierre, H., & Godreuil, S. (2018) · Revue Francophone des Laboratoires · doi:10.1016/s1773-035x(18)30253-3
Microbial community profiling of human gastrointestinal cancers
Thomas, A. M. (2019) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.95.2019.tde-07022019-134344
Organ Microbiota in Cancer Development: The Holy Grail of Biological Carcinogenesis
Kutikhin, A. G., Yuzhalin, A. E., & Брусина, Е. Б. (2012) · Springer eBooks · doi:10.1007/978-94-007-5955-8_6
Epidemiological- and antibiotic susceptibility investigation of Hungarian Bacteroides fragilis group clinical isolates
Sárvári, K. P. (2018) · doi:10.14232/phd.4192
Other Anaerobic Bacteria: Bacteroides, Porphyromonas, Prevotella, Tannerella, Fusobacterium, and Gram-Positive Anaerobic Cocci
Zambon, J. J., & Haraszthy, V. I. (2015) · CRC Press eBooks · doi:10.1201/b17871-47
Research Progress on the Relevance between Intestinal Flora and Colorectal Cancer
Hui, Y., Hou, J., Jia, Y., Dong, M., Feng, F., Jiang, J., & Yang, D. (2020) · Advanced Emergency Medicine · doi:10.18686/aem.v9i2.165
Role of Gut Microbiome in Colorectal Cancer
Sun, X. (2020) · Springer eBooks · doi:10.1007/978-3-030-47384-6_7
E-cadherin and APC in early-onset colorectal cancer
Aitchison, A. (2020) · Otago University Research Archive (University of Otago)
[Trans-translation: co-translation protein quality control system].
Himeno, H., & Muto, A. (2004) · PubMed
Die Rolle des Mikrobioms in der gastrointestinalen Karzinogenese
Vasapolli, R., Macke, L., & Schulz, C. (2021) · TumorDiagnostik & Therapie · doi:10.1055/a-1257-7670
Identification and functional characterization of an RNA binding protein involved in defense signaling pathway and cell death in rice.
Park, C. H. (2009) · The Knowledge Bank (The Ohio State University)
Роль мікробіома в розвитку онкологічної патології
Широбоков, В. П., Янковський, Д. С., & Димент, Г. С. (2021) · Visnik Nacional noi academii nauk Ukrai ni · doi:10.15407/visn2021.11.024 · Cited by 1
Colorectal Cancer-Associated Microbiota
Tjalsma, H., Dutilh, B. E., Boleij, A., & Marchesi, J. R. (2013) · Springer eBooks · doi:10.1007/978-1-4614-6418-1_774-1
Colorectal Cancer-Associated Microbiota
Tjalsma, H., Dutilh, B. E., Boleij, A., & Marchesi, J. R. (2015) · Springer eBooks · doi:10.1007/978-1-4899-7475-4_774
Die Rolle des Mikrobioms in der gastrointestinalen Karzinogenese
Vasapolli, R., Macke, L., & Schulz, C. (2022) · Deutsche Zeitschrift für Onkologie · doi:10.1055/a-1822-7690 · Cited by 1
Microbial Dysbiosis in Oral Cancer
Khan, S., Sinha, R., Sarkar, S., Dixit, A., & Routray, S. (2022) · Springer eBooks · doi:10.1007/978-981-19-0592-6_8
Molecular identification of enterotoxigenic Bacteroides fragilis and the Distribution 16S rRNA gene, bft gene subtypes and gyrb gene in Iraqi patients with diarrhea
(2023) · Journal of Population Therapeutics and Clinical Pharmacology · doi:10.47750/jptcp.2023.30.03.049
Data from Bacterial-Driven Inflammation and Mutant BRAF Expression Combine to Promote Murine Colon Tumorigenesis That Is Sensitive to Immune Checkpoint Therapy
Shields, C. E. D., White, J. R., Chung, L., Wenzel, A. N., Hicks, J. L., Tam, A. J., Chan, J. L., Dejea, C. M., Fan, H., Michel, J. H., et al. (2023) · doi:10.1158/2159-8290.c.6549334.v1
Data from Bacterial-Driven Inflammation and Mutant BRAF Expression Combine to Promote Murine Colon Tumorigenesis That Is Sensitive to Immune Checkpoint Therapy
Shields, C. E. D., White, J. R., Chung, L., Wenzel, A. N., Hicks, J. L., Tam, A. J., Chan, J. L., Dejea, C. M., Fan, H., Michel, J. H., et al. (2023) · doi:10.1158/2159-8290.c.6549334
Gut Microbiota and Host Immune System in Cancer
Sunita, P., Pattanayak, S. P., Ranjan, G., & Bose, P. (2023) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9789815124781123030004
Immune response to intestinal microbial dysbiosis
Kitamoto, S., & Kamada, N. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-98338-9.00005-0
Systemic Onco-Sphere: Host Microbiome and Cancer
Saw, P. E., & Song, E. (2023) · Springer eBooks · doi:10.1007/978-981-99-1183-7_25
Genetic Alterations and Microbial Dysbiosis Underlie Lymph Node Metastasis in Tongue Cancer
Joshi, A., Dharavath, B., Chowdhary, A., Singh, R., Desai, S., & Dutt, A. (2023) · Springer eBooks · doi:10.1007/978-981-99-2196-6_13-1
A IMPORTÂNCIA DAS FEIRAS DE CIÊNCIAS: PERCEPÇÕES DOS PROFESSORES DO ENSINO MÉDIO NO MUNICÍPIO DE CAMPOS SALES – CE
de Sousa, M. M. S., dos Santos, M. A. F., Maia, G. M. D. A., de Souza, D. L., da Cruz, M. F., Pereira, G. G., Silva, L. V., da Cruz, M. T. P., Moura, R. F. D. S., Martins, K. P., et al. (2023) · doi:10.22533/at.ed.1382327079
PREDIÇÃO DE SMALL NUCLEOLAR HOST GENE (SNHG): UMA ANÁLISE IN SILICO
Silva, T. D. C., Matos, A. G. D. M., de Sousa, L. R., Barbosa, E. D. S., Sousa, E. D. L. S., Palmeira, M. D. S., Mendonça, A. F., Teixeira, E. B., da Fonseca, S. S. S., Palmeira, A. C. D. C., et al. (2023) · doi:10.22533/at.ed.1382327071
Principais temas da pesquisa em Ciências Biológicas 3
de Oliveira, A. M. C. (2023) · doi:10.22533/at.ed.138232707
PRINCIPAIS TÉCNICAS DE ENCAPSULAMENTO DE INGREDIENTES ALIMENTÍCIOS
Barros, D. D. M., de Moura, D. F., do Monte, Z. S., Ribeiro, A. N. D. S., Rocha, T. A., da Silva, M. M., Rodrigues, T. H. G., Diniz, M. A., Júnior, A. A. D. S., Gomes, A. D. C., et al. (2023) · doi:10.22533/at.ed.1382327076
INIBIDORES DE PROTEINASES VEGETAIS: AVANÇOS E PERSPECTIVAS
de Souza, L. A., Pando, L. A., & Pando, S. C. (2023) · doi:10.22533/at.ed.1382327074
PERFIL FENOTÍPICO DA VIRULÊNCIA DE Escherichia coli ISOLADAS DE PACIENTES COM CÂNCER DE RETO
Menezes, F., Castro, R. L. S., Alberca, G. G. F., Falcão, P. L., Nunes, A. P., Gushiken, D. S., Pomin, S. A., Almeida, L. A., Torres, A. C. N., Soares, C. R. J., et al. (2023) · doi:10.22533/at.ed.1382327072
APLICAÇÕES BIOMÉDICAS DA CELULOSE BACTERIANA E QUITOSANA: UMA REVISÃO DE 10 ANOS
Carvalho, A. C. Q., da Costa, A. B. I., Melo, I. T. B., Braga, K. P., & de Sousa, R. B. (2023) · doi:10.22533/at.ed.1382327077
OBESIDADE POLIGÊNICA: DESVENDANDO AS BASES GENÉTICAS
Martins, R. D. S., Assis, I. S. D. S., & da Fonseca, A. C. P. (2023) · doi:10.22533/at.ed.1382327073
Gut Microbiota and its impact on the inflammation-dysplasia-cancer sequence
Lazarchuk, I., Parmar, S., & Woźniak, S. (2023) · Medical Journal of Cell Biology · doi:10.2478/acb-2023-0004
The Emerging Role of the Microbiome in Carcinogenesis
Gates, T. J., Dietz, M. A., Martell, M., Balbo, S., Subramanian, S., & Staley, C. M. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95488-4.00093-0
Dietary Pattern Linking to Intestinal Microbial Characteristics and Colorectal Cancer Risk
Sun, J. (2024) · Gastroenterology · doi:10.1053/j.gastro.2024.08.012
Genetic Alterations and Microbial Dysbiosis Underlie Lymph Node Metastasis in Tongue Cancer
Joshi, A., Dharavath, B., Chowdhary, A., Singh, R., Desai, S., & Dutt, A. (2024) · Springer eBooks · doi:10.1007/978-981-99-6263-1_13
Microbiome and colorectal cancer drug resistance
Miya, T. V., Belancio, V. P., & Dlamini, Z. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-33475-7.00016-0
47. DETECTION OF BACTEROIDES FRAGILIS BACTERIA IN TUMORS OF COLORECTAL CANCER PATIENTS
Giang, V. S., Son, H. V., Thân, N. T., Hanh, V. Q., & Thanh, L. D. (2024) · Tạp chí Y học Cộng đồng · doi:10.52163/yhc.v65i13.1889
Resistant starch
Li, Z., & Nie, Q. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-21630-5.00011-3
Quantification of spermine oxidase (SMOX) activity in tissues by HPLC
Foley, J. R., & Holbert, C. E. (2025) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2025.01.075
Fragilysin
Goulas, T., & Gomis‐Rüth, F. X. (2025) · Handbook of Proteolytic Enzymes · doi:10.1016/b978-0-443-28849-4.00123-5
Applying principles of vaccine development to oncomicrobial vaccines
Despins, C. A., Viegas, N. J., & Holt, R. A. (2025) · Blood Advances · doi:10.1182/bloodadvances.2024015610
Additional file 1 of Prevalence of pks + bacteria and enterotoxigenic Bacteroides fragilis in patients with colorectal cancer
Oliero, M., Hajjar, R., Cuisiniere, T., Fragoso, G., Calvé, A., Dagbert, F., Loungnarath, R., Sebajang, H., Schwenter, F., Wassef, R., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26557955
Bacterial effectors disrupt host DNA: Linking sputum microbiome profiles to chromosomal aberrations in leukocytes of lung cancer patients and healthy controls
Druzhinin, V. G., Baranova, E. D., Сергеевич, Д. П., Matskova, L. V., Викторович, Л. А., Zhivotovskiy, A. S., & Yuzhalin, A. E. (2026) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2026.503928
Role of the gut microbiome in the development of colorectal cancer
Shanbhag, A. P. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-40483-2.00040-6
Microbiota and Cancer Therapy
Sobti, R. C., Negi, R. K., & Rana, A. (2026) · Springer eBooks · doi:10.1007/978-981-95-9031-5_4
Cancer and the gut microbiome: the oncogenic impact of dysbiosis
Aden, D., Darji, K., & Zaheer, S. (2026) · Surgical and Experimental Pathology · doi:10.1186/s42047-026-00244-5
Novel clinical intervention pathway based on the pathogenesis mechanism of Enterotoxigenic Bacteroides fragilis
Wang, C., Shi, L., Jin, G., Yonghong.Yang, Zhu, F., & Zhou, G. (2026) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2026.105562
Spatial niches of the colorectal cancer microbiome: differences, interrelationships, and clinical implications of fecal, mucosal, and intratumoral microbiota
Yu, M., Shi, X., Li, D., Li, Y., & Sun, M. (2026) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2026.1904188
Microbiome and Diseases: Colorectal Cancer
Zeißig, S., Jokisch, F., Peuker, K., & Janssen, K. (2026) · Springer eBooks · doi:10.1007/978-3-032-26410-7_15
Gut Microbiota-Derived Extracellular Vesicles in Cancer: Friends or Foes?
Selim, H. M. R. M., Abdallah, D. M., El-Gazar, A. A., Abo-Zalam, H. B., Ragab, G. M., El-Gazar, R. A., Ali‐Tammam, M., & El-Abhar, H. S. (2026) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-026-11227-z

Authors: Ulger Toprak, N., Yagci, A., Gulluoglu, B. M., Akin, M. L., Demirkalem, P., Celenk, T., & Soyletir, G.
Affiliations: Marmara University (TR)
ORCID: Gulluoglu, B.M.
Venue: Clinical Microbiology and Infection
Publisher: Elsevier BV
Published: 2006-08
Volume: 12
Issue: 8
Pages: 782-786
ISSN: 1198-743X (ISSN-L)
DOI: 10.1111/j.1469-0691.2006.01494.x
OpenAlex: W1901660111
Cited by: 454
References: 24
Citations by year: 2026: 12 · 2025: 20 · 2024: 30 · 2023: 43 · 2022: 38 · 2021: 34 · 2020: 36 · 2019: 32 · 2018: 33 · 2017: 26 · 2016: 28 · 2015: 28 · 2014: 16 · 2013: 16 · 2012: 20
FWCI: 2.88
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3072 d)
Locations: Clinical Microbiology and Infection (publishedVersion)
PubMed (publishedVersion)
Dspace Repository (Marmara Üniversitesi) (submittedVersion, other-oa)
Topics: Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Immunology and Microbiology › Microbiology › Escherichia coli research studies
Keywords: Bacteroides fragilis, enterotoxin, enterotoxigenic Bacteroides fragilis, colorectal cancer, cancer etiology, prevalence, gut microbiota
MeSH terms: Adult, Aged, Bacterial Toxins, Bacteroides fragilis, Feces, Female, Humans, Male, Metalloendopeptidases, Middle Aged, Colorectal Neoplasms, Cadherins, Interleukin-8

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

A possible role of Bacteroides fragilis enterotoxin in the aetiology of colorectal cancer

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks