EUCAST technical note on Amphotericin B
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The European Committee on Antimicrobial Susceptibility Testing-Subcommittee on Antifungal Susceptibility Testing (EUCAST-AFST) has determined breakpoints for amphotericin B for Candida spp. This Technical Note is based on the EUCAST amphotericin B rationale document (available on the EUCAST website: http://www.eucast.org). Species-specific breakpoints for C. albicans, C. glabrata, C. krusei, C. parapsilosis and C. tropicalis are S: MIC ≤1 mg/L, R: MIC > 1 mg/L. There are insufficient data to set breakpoints for other species. The breakpoints are based upon pharmacokinetic data, epidemiological cut-ff values and clinical experience. Breakpoints will be reviewed regularly.
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Based on pharmacokinetic data and epidemiological cut-off values, C. albicans, C. tropicalis, C. parapsilosis, C. glabrata, and C. krusei isolates with MIC > 1 mg/L are assumed to be resistant to amphotericin B.
“Based on pharmacokinetic data and epidemiological cut-off values, C. albicans, C. tropicalis, C. parapsilosis, C. glabrata, and C. krusei isolates with MIC > 1 mg/L are assumed to be resistant to amphotericin B [31,62].”
From Treatment of Invasive Candidiasis: A Narrative Review (2018) · cites this paper as [62]
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- Authors
- Lass-Flörl, C., Arendrup, M. C., Rodriguez-Tudela, J.-L., Cuenca-Estrella, M., Donnelly, P., & Hope, W.
- Affiliations
- Statens Serum Institut (DK)
- Centro Nacional de Microbiologia (ES)
- Radboud University Medical Center (NL)
- University of Manchester (GB)
- Venue
- Clinical Microbiology and Infection
- Publisher
- Elsevier BV
- Published
- 2011-12
- Volume
- 17
- Issue
- 12
- Pages
- E27-E29
- ISSN
- 1198-743X (ISSN-L)
- OpenAlex
- W1934077280
- Cited by
- 49
- References
- 15
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 3 · 2019: 5 · 2018: 4 · 2017: 5 · 2016: 3 · 2015: 4 · 2014: 1 · 2013: 7 · 2012: 6
- FWCI
- 3.24
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Clinical Microbiology and Infection (publishedVersion)
- PubMed (publishedVersion)
- Università Politecnica delle Marche (Università Politecnica delle Marche) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Bacterial Identification and Susceptibility Testing
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Fungal Plant Pathogen Control
- Keywords
- amphotericin B, antimicrobial susceptibility breakpoints, Candida, antifungal susceptibility testing, Candida albicans, Candida glabrata, Candida krusei, Candida parapsilosis, Candida tropicalis, minimum inhibitory concentration
- MeSH terms
- Amphotericin B, Antifungal Agents, Candida, Candidiasis, Humans, Microbial Sensitivity Tests, Drug Resistance, Fungal
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