The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Extensions to multivariate normal models for pedigree analysis
Abstract
Summary: Lange, Westlake & Spence (1976) used the assumption of multivariate normality to apply a likelihood method to the analysis of quantitative traits measured over pedigrees. We now introduce a test of the assumption of multivariate normality and methods for the detection of outlying families and outlying individuals. We also introduce a method for the estimation of effects of measured genetic markers as variance components, a flexible parameterization to estimate effects of shared family environment, and a method to allow for the ascertainment of pedigrees through probands. These innovations have been applied using numerical methods for maximization of the likelihood. Simulation studies and available theory suggest that the likelihood ratio criterion used in significance testing follows the expected asymptotic distribution with sample sizes encountered in typical applications.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
XV.—The Correlation between Relatives on the Supposition of Mendelian Inheritance.
Fisher, R. A. (1919) · Transactions of the Royal Society of Edinburgh · doi:10.1017/s0080456800012163 · Cited by 4,387
Cited by
Winkler, A. M., Kochunov, P., Blangero, J., Almasy, L., Zilles, K., Fox, P. T., Duggirala, R., & Glahn, D. C. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2009.12.028 · Cited by 1,172
A General Test of Association for Quantitative Traits in Nuclear Families
Abecasis, G. R., Cardon, L. R., & Cookson, W. O. C. (2000) · The American Journal of Human Genetics · doi:10.1086/302698 · Cited by 1,126
Bicuspid aortic valve is heritable
Cripe, L., Andelfinger, G., Martin, L. J., Shooner, K., & Benson, D. W. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2004.03.050 · Cited by 635
Large Upward Bias in Estimation of Locus-Specific Effects from Genomewide Scans
Göring, H. H. H., Terwilliger, J. D., & Blangero, J. (2001) · The American Journal of Human Genetics · doi:10.1086/324471 · Cited by 483
The Familial Aggregation of Obstructive Sleep Apnea
Redline, S., Tishler, P. V., Tosteson, T. D., Williamson, J., Kump, K., Browner, I., Ferrette, V., & Krejci, P. (1995) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm/151.3_pt_1.682 · Cited by 473
Metadata
- Authors
- HOPPER, J. L., & MATHEWS, J. D.
- Venue
- Annals of Human Genetics
- Publisher
- Wiley
- Published
- 1982-10
- Volume
- 46
- Issue
- 4
- Pages
- 373-383
- ISSN
- 0003-4800 (ISSN-L)
- 1469-1809
- OpenAlex
- W2062318434
- Cited by
- 509
- References
- 1
- FWCI
- 5.02
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Extensions to multivariate normal models for pedigree analysis. https://app.cochat.ai/papers/10.1111/j.1469-1809.1982.tb01588.x
- The paper
- HOPPER, J. L., & MATHEWS, J. D. (1982). Extensions to multivariate normal models for pedigree analysis. Annals of Human Genetics. https://doi.org/10.1111/j.1469-1809.1982.tb01588.x
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
