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Cited by 173Attention Deficit Hyperactivity DisorderNeural and Behavioral Psychology StudiesNeurotransmitter Receptor Influence on Behavior

The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.

ADHD‐ and medication‐related brain activation effects in concordantly affected parent–child dyads with ADHD

Epstein, Jeffery N., Casey, B.J., Tonev, Simon T., Davidson, Matthew C., Reiss, Allan L., Garrett, Amy, Hinshaw, Stephen P., Greenhill, Laurence L., Glover, Gary, Shafritz, Keith M., Vitolo, Alan, Kotler, Lisa A., Jarrett, Matthew A., Spicer, Julie·2007·Journal of Child Psychology and Psychiatry
DOI 10.1111/j.1469-7610.2007.01761.x
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Abstract

BACKGROUND: Several studies have documented fronto-striatal dysfunction in children and adolescents with attention deficit/hyperactivity disorder (ADHD) using response inhibition tasks. Our objective was to examine functional brain abnormalities among youths and adults with ADHD and to examine the relations between these neurobiological abnormalities and response to stimulant medication. METHOD: A group of concordantly diagnosed ADHD parent-child dyads was compared to a matched sample of normal parent-child dyads. In addition, ADHD dyads were administered double-blind methylphenidate and placebo in a counterbalanced fashion over two consecutive days of testing. Frontostriatal function was measured using functional magnetic resonance imaging (fMRI) during performance of a go/no-go task. RESULTS: Youths and adults with ADHD showed attenuated activity in fronto-striatal regions. In addition, adults with ADHD appeared to activate non-fronto-striatal regions more than normals. A stimulant medication trial showed that among youths, stimulant medication increased activation in fronto-striatal and cerebellar regions. In adults with ADHD, increases in activation were observed in the striatum and cerebellum, but not in prefrontal regions. CONCLUSIONS: This study extends findings of fronto-striatal dysfunction to adults with ADHD and highlights the importance of frontostriatal and frontocerebellar circuitry in this disorder, providing evidence of an endophenotype for examining the genetics of ADHD.

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Crossref · 10.1111/j.1469-7610.2007.01761.x

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Research works printed but not linked: 1

  1. Epstein J.N., 2001, Conners’ Adult ADHD Diagnostic Interview for DSM‐IV

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Metadata

Authors
Epstein, J. N., Casey, B. J., Tonev, S. T., Davidson, M. C., Reiss, A. L., Garrett, A., Hinshaw, S. P., Greenhill, L. L., Glover, G., Shafritz, K. M., Vitolo, A., Kotler, L. A., Jarrett, M. A., & Spicer, J.
Affiliations
  • Cincinnati Children's Hospital Medical Center (US)
  • Cornell University (US)
  • Duke Medical Center (US)
  • Stanford Medicine (US)
  • University of California, Berkeley (US)
  • Columbia University Irving Medical Center (US)
  • Hofstra University (US)
Corresponding author
Epstein, Jeffery N.
ORCID
Venue
Journal of Child Psychology and Psychiatry
Publisher
Wiley
Published
2007-08-09
Volume
48
Issue
9
Pages
899-913
ISSN
  • 0021-9630 (ISSN-L)
  • 1469-7610
DOI
10.1111/j.1469-7610.2007.01761.x
OpenAlex
W1832744912
Cited by
173
References
65
Citations by year
2026: 2 · 2025: 1 · 2024: 3 · 2023: 4 · 2022: 4 · 2021: 7 · 2020: 3 · 2019: 4 · 2018: 7 · 2017: 8 · 2016: 8 · 2015: 9 · 2014: 25 · 2013: 20 · 2012: 15
FWCI
7.64
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Journal of Child Psychology and Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Institute of Mental Health (R01MH064166, R01MH064177, MH064182, K24MH064478, MH064177, R01MH064179, MH064166, R01MH064182, MH064179, MH064176, R01MH064176)
  • National Center for Research Resources (RR 09784, P41RR009784)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
attention deficit hyperactivity disorder, frontostriatal dysfunction, response inhibition, go/no-go task, methylphenidate, stimulant medication response, cerebellum, parent-child dyads, adult ADHD, endophenotypes, striatum
MeSH terms
Adult, Central Nervous System Stimulants, Attention Deficit Disorder with Hyperactivity, Brain, Child, Double-Blind Method, Female, Humans, Magnetic Resonance Imaging, Male, Methylphenidate, Parent-Child Relations

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